HUMAN:NOD2

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	NOD2 ( synonyms: CARD15, IBD1 )
Protein Name(s)	Nucleotide-binding oligomerization domain-containing protein 2 Caspase recruitment domain-containing protein 15 Inflammatory bowel disease protein 1
External Links
UniProt Identifier	NOD2_HUMAN
UniProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8,
EMBL	AF178930, AF385089, AF385090, AJ303140,
RefSeq	NP_071445.1,
Ensembl	ENST00000300589,
Pfam	PF00619,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0051403	stress-activated MAPK cascade	Reactome:REACT_21308	TAS: Traceable Author Statement		P
	GO:0032498	detection of muramyl dipeptide	PMID:15998797^[1]	IDA: Inferred from Direct Assay		P
	GO:0034130	toll-like receptor 1 signaling pathway	Reactome:REACT_8005	TAS: Traceable Author Statement		P
	GO:0005886	plasma membrane	PMID:15998797^[1]	IDA: Inferred from Direct Assay		C
	GO:0032740	positive regulation of interleukin-17 production	PMID:17919942^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0005515	protein binding	PMID:16714539^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q96RT1	F
	GO:2000363	positive regulation of prostaglandin-E synthase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0006952	defense response	PMID:15967716^[4]	TAS: Traceable Author Statement		P
	GO:0005829	cytosol	PMID:15998797^[1]	IDA: Inferred from Direct Assay		C
	GO:0071224	cellular response to peptidoglycan	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0050700	CARD domain binding	PMID:11087742^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O43353	F
	GO:0000187	activation of MAPK activity	Reactome:REACT_21399	TAS: Traceable Author Statement		P
	GO:0002367	cytokine production involved in immune response	PMID:16260731^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0045087	innate immune response	Reactome:REACT_6802	TAS: Traceable Author Statement		P
	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	PMID:15276183^[7]	EXP: Inferred from Experiment		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	PMID:15276183^[7]	EXP: Inferred from Experiment		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6782	TAS: Traceable Author Statement		P
	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0005515	protein binding	PMID:19337385^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q9C000	F
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0050727	regulation of inflammatory response	PMID:11385577^[9]	IC: Inferred by Curator	GO:0051092	P
	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0002224	toll-like receptor signaling pathway	Reactome:REACT_8006	TAS: Traceable Author Statement		P
	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0019901	protein kinase binding	PMID:15075345^[10]	IPI: Inferred from Physical Interaction	UniProtKB:O43318	F
	GO:0051259	protein oligomerization	PMID:15967716^[4]	TAS: Traceable Author Statement		P
	GO:0032495	response to muramyl dipeptide	PMID:16414084^[11]	IDA: Inferred from Direct Assay		P
	GO:0007254	JNK cascade	Reactome:REACT_21368	TAS: Traceable Author Statement		P
	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0090022	regulation of neutrophil chemotaxis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:11385577^[9]	IDA: Inferred from Direct Assay		P
	GO:0032874	positive regulation of stress-activated MAPK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0046330	positive regulation of JNK cascade	PMID:17187069^[12]	IDA: Inferred from Direct Assay		P
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:12527755^[13]	IDA: Inferred from Direct Assay		P
	GO:0032703	negative regulation of interleukin-2 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0005515	protein binding	PMID:17337451^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q7L5N1	F
	GO:0005515	protein binding	PMID:19337385^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P59046	F
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0002381	immunoglobulin production involved in immunoglobulin mediated immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0002710	negative regulation of T cell mediated immunity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0046330	positive regulation of JNK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0005829	cytosol	Reactome:REACT_6935	TAS: Traceable Author Statement		C
	GO:0042742	defense response to bacterium	PMID:15653568^[15]	IDA: Inferred from Direct Assay		P
	GO:0005829	cytosol	Reactome:REACT_6973	TAS: Traceable Author Statement		C
	GO:0071608	macrophage inflammatory protein-1 alpha production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:2000110	negative regulation of macrophage apoptosis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0045087	innate immune response	PMID:17690884^[16]	NAS: Non-traceable Author Statement		P
	GO:0032500	muramyl dipeptide binding	PMID:15998797^[1]	IDA: Inferred from Direct Assay		F
	GO:0009595	detection of biotic stimulus	PMID:15967716^[4]	TAS: Traceable Author Statement		P
	GO:0051353	positive regulation of oxidoreductase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0032760	positive regulation of tumor necrosis factor production	PMID:17187069^[12]	IDA: Inferred from Direct Assay		P
	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	PMID:12527755^[13]	IDA: Inferred from Direct Assay		P
	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0002227	innate immune response in mucosa	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0032496	response to lipopolysaccharide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0050766	positive regulation of phagocytosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0005829	cytosol	Reactome:REACT_21367	TAS: Traceable Author Statement		C
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:12527755^[13]	IDA: Inferred from Direct Assay		P
	GO:0019899	enzyme binding	PMID:15753091^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q9P0J0	F
	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0005829	cytosol	Reactome:REACT_21338	TAS: Traceable Author Statement		C
	GO:0032498	detection of muramyl dipeptide	PMID:12527755^[13]	IDA: Inferred from Direct Assay		P
	GO:0032701	negative regulation of interleukin-18 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0050871	positive regulation of B cell activation	PMID:20844241^[18]	IDA: Inferred from Direct Assay		P
	GO:0005515	protein binding	PMID:11472070^[19]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPP4	F
	GO:0043410	positive regulation of MAPKKK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0005515	protein binding	PMID:19337385^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q96P20	F
	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0043330	response to exogenous dsRNA	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:15107016^[20]	IDA: Inferred from Direct Assay		P
	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0034142	toll-like receptor 4 signaling pathway	Reactome:REACT_6890	TAS: Traceable Author Statement		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:11087742^[5]	IDA: Inferred from Direct Assay		P
	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0034134	toll-like receptor 2 signaling pathway	Reactome:REACT_7980	TAS: Traceable Author Statement		P
	GO:0032494	response to peptidoglycan	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0005737	cytoplasm	PMID:15967716^[4]	TAS: Traceable Author Statement		C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	C
	GO:0032495	response to muramyl dipeptide	PMID:15998797^[1]	IDA: Inferred from Direct Assay		P
	GO:0032695	negative regulation of interleukin-12 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0032760	positive regulation of tumor necrosis factor production	PMID:21040358^[21]	IMP: Inferred from Mutant Phenotype		P
	GO:0032689	negative regulation of interferon-gamma production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0016045	detection of bacterium	PMID:15653568^[15]	IDA: Inferred from Direct Assay		P
	GO:0035419	activation of MAPK activity involved in innate immune response	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0005515	protein binding	PMID:15107016^[20]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPP4	F
	GO:0045089	positive regulation of innate immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0006965	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0008063	Toll signaling pathway	Reactome:REACT_6894	TAS: Traceable Author Statement		P
	GO:0046645	positive regulation of gamma-delta T cell activation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q6E804	P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6976	TAS: Traceable Author Statement		P
	GO:0002253	activation of immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0031982	vesicle	PMID:15998797^[1]	IDA: Inferred from Direct Assay		C
	GO:0042834	peptidoglycan binding	PMID:15998797^[1]	IDA: Inferred from Direct Assay		F
	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0032874	positive regulation of stress-activated MAPK cascade	PMID:17187069^[12]	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Reactome:REACT_21281	TAS: Traceable Author Statement		P
	GO:0005515	protein binding	PMID:15107016^[20]	IPI: Inferred from Physical Interaction	UniProtKB:P29466	F
	GO:0032755	positive regulation of interleukin-6 production	PMID:16414084^[11]	IDA: Inferred from Direct Assay		P
	GO:0032735	positive regulation of interleukin-12 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0009986	cell surface	PMID:16714539^[3]	IDA: Inferred from Direct Assay		C
	GO:0034138	toll-like receptor 3 signaling pathway	Reactome:REACT_6783	TAS: Traceable Author Statement		P
	GO:0002830	positive regulation of type 2 immune response	PMID:21172192^[22]	IMP: Inferred from Mutant Phenotype		P
	GO:0008180	signalosome	PMID:17337451^[14]	IDA: Inferred from Direct Assay		C
	GO:0032495	response to muramyl dipeptide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050538	P
	GO:0005515	protein binding	PMID:19337385^[8]	IPI: Inferred from Physical Interaction	UniProtKB:O43353	F
	GO:0032731	positive regulation of interleukin-1 beta production	PMID:21040358^[21]	IMP: Inferred from Mutant Phenotype		P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	P
	GO:0035556	intracellular signal transduction	PMID:15653568^[15]	IDA: Inferred from Direct Assay		P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0000187	activation of MAPK activity	Reactome:REACT_21399	TAS: Traceable Author Statement		P
	GO:0002218	activation of innate immune response	Reactome:REACT_75913	TAS: Traceable Author Statement		P
	GO:0002224	toll-like receptor signaling pathway	Reactome:REACT_8006	TAS: Traceable Author Statement		P
	GO:0002227	innate immune response in mucosa	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0002253	activation of immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0002367	cytokine production involved in immune response	PMID:16260731^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0002381	immunoglobulin production involved in immunoglobulin mediated immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0002710	negative regulation of T cell mediated immunity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_27215	TAS: Traceable Author Statement		P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_6788	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6782	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6976	TAS: Traceable Author Statement		P
	GO:0002830	positive regulation of type 2 immune response	PMID:21172192^[22]	IMP: Inferred from Mutant Phenotype		P
	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0005515	protein binding	PMID:11472070^[19]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPP4	F
	GO:0005515	protein binding	PMID:15107016^[20]	IPI: Inferred from Physical Interaction	UniProtKB:P29466	F
	GO:0005515	protein binding	PMID:15107016^[20]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPP4	F
	GO:0005515	protein binding	PMID:16714539^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q96RT1	F
	GO:0005515	protein binding	PMID:17337451^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q7L5N1	F
	GO:0005515	protein binding	PMID:19337385^[8]	IPI: Inferred from Physical Interaction	UniProtKB:O43353	F
	GO:0005515	protein binding	PMID:19337385^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P59046	F
	GO:0005515	protein binding	PMID:19337385^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q96P20	F
	GO:0005515	protein binding	PMID:19337385^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q9C000	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:15967716^[4]	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	PMID:15998797^[1]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	Reactome:REACT_21338	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_21367	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6935	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6973	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75766	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75789	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75796	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75833	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75843	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75887	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75888	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75893	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75903	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75924	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	PMID:15998797^[1]	IDA: Inferred from Direct Assay		C
	GO:0006952	defense response	PMID:15967716^[4]	TAS: Traceable Author Statement		P
	GO:0006965	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0007254	JNK cascade	Reactome:REACT_21368	TAS: Traceable Author Statement		P
	GO:0008063	Toll signaling pathway	Reactome:REACT_6894	TAS: Traceable Author Statement		P
	GO:0009595	detection of biotic stimulus	PMID:15967716^[4]	TAS: Traceable Author Statement		P
	GO:0009986	cell surface	PMID:16714539^[3]	IDA: Inferred from Direct Assay		C
	GO:0016045	detection of bacterium	PMID:15653568^[15]	IDA: Inferred from Direct Assay		P
	GO:0019899	enzyme binding	PMID:15753091^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q9P0J0	F
	GO:0019901	protein kinase binding	PMID:15075345^[10]	IPI: Inferred from Physical Interaction	UniProtKB:O43318	F
	GO:0031982	vesicle	PMID:15998797^[1]	IDA: Inferred from Direct Assay		C
	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032494	response to peptidoglycan	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032495	response to muramyl dipeptide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032495	response to muramyl dipeptide	PMID:15998797^[1]	IDA: Inferred from Direct Assay		P
	GO:0032495	response to muramyl dipeptide	PMID:16414084^[11]	IDA: Inferred from Direct Assay		P
	GO:0032496	response to lipopolysaccharide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032498	detection of muramyl dipeptide	PMID:12527755^[13]	IDA: Inferred from Direct Assay		P
	GO:0032498	detection of muramyl dipeptide	PMID:15998797^[1]	IDA: Inferred from Direct Assay		P
	GO:0032500	muramyl dipeptide binding	PMID:15998797^[1]	IDA: Inferred from Direct Assay		F
	GO:0032689	negative regulation of interferon-gamma production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032695	negative regulation of interleukin-12 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032701	negative regulation of interleukin-18 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032703	negative regulation of interleukin-2 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032731	positive regulation of interleukin-1 beta production	PMID:21040358^[21]	IMP: Inferred from Mutant Phenotype		P
	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0032735	positive regulation of interleukin-12 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032740	positive regulation of interleukin-17 production	PMID:17919942^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032755	positive regulation of interleukin-6 production	PMID:16414084^[11]	IDA: Inferred from Direct Assay		P
	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032760	positive regulation of tumor necrosis factor production	PMID:17187069^[12]	IDA: Inferred from Direct Assay		P
	GO:0032760	positive regulation of tumor necrosis factor production	PMID:21040358^[21]	IMP: Inferred from Mutant Phenotype		P
	GO:0032874	positive regulation of stress-activated MAPK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0032874	positive regulation of stress-activated MAPK cascade	PMID:17187069^[12]	IDA: Inferred from Direct Assay		P
	GO:0034130	toll-like receptor 1 signaling pathway	Reactome:REACT_8005	TAS: Traceable Author Statement		P
	GO:0034134	toll-like receptor 2 signaling pathway	Reactome:REACT_7980	TAS: Traceable Author Statement		P
	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0034138	toll-like receptor 3 signaling pathway	Reactome:REACT_6783	TAS: Traceable Author Statement		P
	GO:0034142	toll-like receptor 4 signaling pathway	Reactome:REACT_6890	TAS: Traceable Author Statement		P
	GO:0035419	activation of MAPK activity involved in innate immune response	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0035556	intracellular signal transduction	PMID:15653568^[15]	IDA: Inferred from Direct Assay		P
	GO:0042742	defense response to bacterium	PMID:15653568^[15]	IDA: Inferred from Direct Assay		P
	GO:0042834	peptidoglycan binding	PMID:15998797^[1]	IDA: Inferred from Direct Assay		F
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:11087742^[5]	IDA: Inferred from Direct Assay		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:12527755^[13]	IDA: Inferred from Direct Assay		P
	GO:0043330	response to exogenous dsRNA	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0043410	positive regulation of MAPKKK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0045087	innate immune response	PMID:17690884^[16]	NAS: Non-traceable Author Statement		P
	GO:0045087	innate immune response	Reactome:REACT_6802	TAS: Traceable Author Statement		P
	GO:0045089	positive regulation of innate immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0046330	positive regulation of JNK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0046330	positive regulation of JNK cascade	PMID:17187069^[12]	IDA: Inferred from Direct Assay		P
	GO:0046645	positive regulation of gamma-delta T cell activation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q6E804	P
	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0050700	CARD domain binding	PMID:11087742^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O43353	F
	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:15107016^[20]	IDA: Inferred from Direct Assay		P
	GO:0050727	regulation of inflammatory response	PMID:11385577^[9]	IC: Inferred by Curator	GO:0051092	P
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0050766	positive regulation of phagocytosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0050871	positive regulation of B cell activation	PMID:20844241^[18]	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:11385577^[9]	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:12527755^[13]	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Reactome:REACT_21281	TAS: Traceable Author Statement		P
	GO:0051259	protein oligomerization	PMID:15967716^[4]	TAS: Traceable Author Statement		P
	GO:0051353	positive regulation of oxidoreductase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0051403	stress-activated MAPK cascade	Reactome:REACT_21308	TAS: Traceable Author Statement		P
	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	Reactome:REACT_75776	TAS: Traceable Author Statement		P
	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	PMID:12527755^[13]	IDA: Inferred from Direct Assay		P
	GO:0071224	cellular response to peptidoglycan	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0071608	macrophage inflammatory protein-1 alpha production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:0090022	regulation of neutrophil chemotaxis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113773	P
	GO:2000110	negative regulation of macrophage apoptosis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
	GO:2000363	positive regulation of prostaglandin-E synthase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8K3Z0	P
colocalizes_with	GO:0008180	signalosome	PMID:17337451^[14]	IDA: Inferred from Direct Assay		C
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Barnich N et al. (2005) Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J Cell Biol 170: 21-6 PubMed GONUTS page
↑ ^2.0 ^2.1 van Beelen AJ et al. (2007) Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27: 660-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Kufer TA et al. (2006) Role for erbin in bacterial activation of Nod2. Infect Immun 74: 3115-24 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Martinon F & Tschopp J (2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol 26: 447-54 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Ogura Y et al. (2001) Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 276: 4812-8 PubMed GONUTS page
↑ ^6.0 ^6.1 Netea MG et al. (2005) IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A 102: 16309-14 PubMed GONUTS page
↑ ^7.0 ^7.1 Gangloff M & Gay NJ (2004) MD-2: the Toll 'gatekeeper' in endotoxin signalling. Trends Biochem Sci 29: 294-300 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Wagner RN et al. (2009) Evaluation of Nod-like receptor (NLR) effector domain interactions. PLoS One 4: e4931 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Ogura Y et al. (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411: 603-6 PubMed GONUTS page
↑ ^10.0 ^10.1 Chen CM et al. (2004) Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J Biol Chem 279: 25876-82 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Davey MP et al. (2006) Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide. Microvasc Res 71: 103-7 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Hsu YM et al. (2007) The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol 8: 198-205 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Girardin SE et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278: 8869-72 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 da Silva Correia J et al. (2007) The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis. J Biol Chem 282: 12557-65 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Opitz B et al. (2005) Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ Res 96: 319-26 PubMed GONUTS page
↑ ^16.0 ^16.1 Tattoli I et al. (2007) The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation. Semin Immunopathol 29: 289-301 PubMed GONUTS page
↑ ^17.0 ^17.1 Barnich N et al. (2005) GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells. J Biol Chem 280: 19021-6 PubMed GONUTS page
↑ ^18.0 ^18.1 Petterson T et al. (2011) Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors. J Leukoc Biol 89: 177-87 PubMed GONUTS page
↑ ^19.0 ^19.1 Damiano JS et al. (2001) CLAN, a novel human CED-4-like gene. Genomics 75: 77-83 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 Damiano JS et al. (2004) Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem J 381: 213-9 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Brooks MN et al. (2011) NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages. Cell Microbiol 13: 402-18 PubMed GONUTS page
↑ ^22.0 ^22.1 Butler M et al. (2007) NOD2 activity modulates the phenotype of LPS-stimulated dendritic cells to promote the development of T-helper type 2-like lymphocytes - Possible implications for NOD2-associated Crohn's disease. J Crohns Colitis 1: 106-15 PubMed GONUTS page

[PMID:15998797-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Barnich N et al. (2005) Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J Cell Biol 170: 21-6 PubMed GONUTS page

[PMID:17919942-1] 2.0 ^2.1 van Beelen AJ et al. (2007) Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27: 660-9 PubMed GONUTS page

[PMID:16714539-2] 3.0 ^3.1 ^3.2 ^3.3 Kufer TA et al. (2006) Role for erbin in bacterial activation of Nod2. Infect Immun 74: 3115-24 PubMed GONUTS page

[PMID:15967716-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Martinon F & Tschopp J (2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol 26: 447-54 PubMed GONUTS page

[PMID:11087742-4] 5.0 ^5.1 ^5.2 ^5.3 Ogura Y et al. (2001) Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 276: 4812-8 PubMed GONUTS page

[PMID:16260731-5] 6.0 ^6.1 Netea MG et al. (2005) IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A 102: 16309-14 PubMed GONUTS page

[PMID:15276183-6] 7.0 ^7.1 Gangloff M & Gay NJ (2004) MD-2: the Toll 'gatekeeper' in endotoxin signalling. Trends Biochem Sci 29: 294-300 PubMed GONUTS page

[PMID:19337385-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Wagner RN et al. (2009) Evaluation of Nod-like receptor (NLR) effector domain interactions. PLoS One 4: e4931 PubMed GONUTS page

[PMID:11385577-8] 9.0 ^9.1 ^9.2 ^9.3 Ogura Y et al. (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411: 603-6 PubMed GONUTS page

[PMID:15075345-9] 10.0 ^10.1 Chen CM et al. (2004) Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J Biol Chem 279: 25876-82 PubMed GONUTS page

[PMID:16414084-10] 11.0 ^11.1 ^11.2 ^11.3 Davey MP et al. (2006) Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide. Microvasc Res 71: 103-7 PubMed GONUTS page

[PMID:17187069-11] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Hsu YM et al. (2007) The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol 8: 198-205 PubMed GONUTS page

[PMID:12527755-12] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Girardin SE et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278: 8869-72 PubMed GONUTS page

[PMID:17337451-13] 14.0 ^14.1 ^14.2 ^14.3 da Silva Correia J et al. (2007) The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis. J Biol Chem 282: 12557-65 PubMed GONUTS page

[PMID:15653568-14] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Opitz B et al. (2005) Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ Res 96: 319-26 PubMed GONUTS page

[PMID:17690884-15] 16.0 ^16.1 Tattoli I et al. (2007) The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation. Semin Immunopathol 29: 289-301 PubMed GONUTS page

[PMID:15753091-16] 17.0 ^17.1 Barnich N et al. (2005) GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells. J Biol Chem 280: 19021-6 PubMed GONUTS page

[PMID:20844241-17] 18.0 ^18.1 Petterson T et al. (2011) Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors. J Leukoc Biol 89: 177-87 PubMed GONUTS page

[PMID:11472070-18] 19.0 ^19.1 Damiano JS et al. (2001) CLAN, a novel human CED-4-like gene. Genomics 75: 77-83 PubMed GONUTS page

[PMID:15107016-19] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 Damiano JS et al. (2004) Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem J 381: 213-9 PubMed GONUTS page

[PMID:21040358-20] 21.0 ^21.1 ^21.2 ^21.3 Brooks MN et al. (2011) NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages. Cell Microbiol 13: 402-18 PubMed GONUTS page

[PMID:21172192-21] 22.0 ^22.1 Butler M et al. (2007) NOD2 activity modulates the phenotype of LPS-stimulated dendritic cells to promote the development of T-helper type 2-like lymphocytes - Possible implications for NOD2-associated Crohn's disease. J Crohns Colitis 1: 106-15 PubMed GONUTS page

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HUMAN:NOD2

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