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HUMAN:NICA
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | NCSTN (synonyms: KIAA0253) | |
| Protein Name(s) | Nicastrin | |
| External Links | ||
| EMBL | AF240468 AY359120 AL445230 CH471121 BC047621 D87442 | |
| IPI | IPI00021983 IPI00375688 | |
| RefSeq | NP_056146.1 | |
| UniGene | Hs.517249 | |
| ProteinModelPortal | Q92542 | |
| SMR | Q92542 | |
| DIP | DIP-36336N | |
| IntAct | Q92542 | |
| MINT | MINT-3048708 | |
| STRING | Q92542 | |
| PRIDE | Q92542 | |
| Ensembl | ENST00000294785 | |
| GeneID | 23385 | |
| KEGG | hsa:23385 | |
| UCSC | uc001fvx.1 uc001fvy.1 | |
| CTD | 23385 | |
| GeneCards | GC01P131669 | |
| H-InvDB | HIX0001217 | |
| HGNC | HGNC:17091 | |
| HPA | CAB021982 | |
| MIM | 142690 605254 | |
| neXtProt | NX_Q92542 | |
| GeneTree | ENSGT00390000014633 | |
| HOGENOM | HBG447352 | |
| HOVERGEN | HBG006497 | |
| InParanoid | Q92542 | |
| OMA | ELEFITL | |
| OrthoDB | EOG4STS48 | |
| PhylomeDB | Q92542 | |
| Pathway_Interaction_DB | p75ntrpathway ps1pathway syndecan_3_pathway | |
| Reactome | REACT_111102 | |
| NextBio | 45500 | |
| ArrayExpress | Q92542 | |
| Bgee | Q92542 | |
| CleanEx | HS_NCSTN | |
| Genevestigator | Q92542 | |
| GermOnline | ENSG00000162736 | |
| GO | GO:0005783 GO:0005794 GO:0005887 GO:0042470 GO:0004190 GO:0005515 GO:0042987 GO:0006915 GO:0008624 GO:0006509 GO:0031293 GO:0048011 GO:0007220 GO:0007219 GO:0043085 GO:0016485 | |
| InterPro | IPR008710 | |
| KO | K06171 | |
| PANTHER | PTHR21092 | |
| Pfam | PF05450 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004175 |
endopeptidase activity |
Reactome:REACT_13609 |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
||
| GO:0004190 |
aspartic-type endopeptidase activity |
Reactome:REACT_1306 |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
||
| GO:0004190 |
aspartic-type endopeptidase activity |
Reactome:REACT_1784 |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
||
| GO:0004190 |
aspartic-type endopeptidase activity |
Reactome:REACT_1803 |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
||
| GO:0004190 |
aspartic-type endopeptidase activity |
Reactome:REACT_965 |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005624 |
membrane fraction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000003550 |
C |
Seeded From UniProt |
|||
| GO:0005765 |
lysosomal membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000008150 |
C |
Seeded From UniProt |
|||
| GO:0005783 |
endoplasmic reticulum |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000003550 |
C |
Seeded From UniProt |
|||
| GO:0005783 |
endoplasmic reticulum |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005783 |
endoplasmic reticulum |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005794 |
Golgi apparatus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000003550 |
C |
Seeded From UniProt |
|||
| GO:0005794 |
Golgi apparatus |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005794 |
Golgi apparatus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000003550 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
Reactome:REACT_1306 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_13609 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_13710 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_1784 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_1803 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_965 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005887 |
integral to plasma membrane |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005887 |
integral to plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006508 |
proteolysis |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006509 |
membrane protein ectodomain proteolysis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0006509 |
membrane protein ectodomain proteolysis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006915 |
apoptosis |
Reactome:REACT_13643 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0007219 |
Notch signaling pathway |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007219 |
Notch signaling pathway |
Reactome:REACT_299 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0007220 |
Notch receptor processing |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007220 |
Notch receptor processing |
Reactome:REACT_691 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0008233 |
peptidase activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000008150 |
F |
Seeded From UniProt |
|||
| GO:0008233 |
peptidase activity |
Reactome:REACT_13710 |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
||
| GO:0008624 |
induction of apoptosis by extracellular signals |
Reactome:REACT_13720 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0162 |
C |
Seeded From UniProt |
|||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
NAS: Non-traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0016485 |
protein processing |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016485 |
protein processing |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0016485 |
protein processing |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0031293 |
membrane protein intracellular domain proteolysis |
Reactome:REACT_13443 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0042470 |
melanosome |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0161 |
C |
Seeded From UniProt |
|||
| GO:0042987 |
amyloid precursor protein catabolic process |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0043085 |
positive regulation of catalytic activity |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0043085 |
positive regulation of catalytic activity |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0048011 |
nerve growth factor receptor signaling pathway |
Reactome:REACT_11061 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0048011 |
nerve growth factor receptor signaling pathway |
Reactome:REACT_13776 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Lee SF et al. (2002) Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem 277: 45013-9 PubMed GONUTS page
- ↑ Chen F et al. (2006) TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature 440: 1208-12 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Fraering PC et al. (2004) Purification and characterization of the human gamma-secretase complex. Biochemistry 43: 9774-89 PubMed GONUTS page
- ↑ 4.0 4.1 Yu G et al. (2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407: 48-54 PubMed GONUTS page
