HUMAN:NF1

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Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NF1
Protein Name(s)	Neurofibromin Neurofibromatosis-related protein NF-1 Neurofibromin truncated
External Links
UniProt	P21359
EMBL	M89914 M82814 M60496 D12625 M38106 M38107 AY796305 M38116 M38108 M38109 M38110 M38111 M38112 M38113 M38114 M38115 Y07853 U17690 U17680 U17681 U17682 U17683 U17684 U17685 U17686 U17687 U17688 U17689 U17690 U17680 U17681 U17682 U17683 U17684 U17685 U17687 U17688 U17689 U17656 U17659 U17662 U17668 U17667 U17673 U17677 U17676 M60915 M60915 M61213 S51751 D10490
IPI	IPI00220513 IPI00220514 IPI00299512 IPI00304235
PIR	B55282 I78852
RefSeq	NP_000258.1 NP_001035957.1 NP_001121619.1
UniGene	Hs.113577
PDB	1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7
PDBsum	1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7
ProteinModelPortal	P21359
SMR	P21359
IntAct	P21359
MINT	MINT-1504522
STRING	P21359
PhosphoSite	P21359
DMDM	548350
PRIDE	P21359
Ensembl	ENST00000358273
GeneID	4763
KEGG	hsa:4763
UCSC	uc002hge.1 uc002hgg.1 uc002hgh.1
CTD	4763
GeneCards	GC17P025632
H-InvDB	HIX0013698
HGNC	HGNC:7765
HPA	CAB004786
MIM	114500 162200 162210 193520 601321 607785 613113
neXtProt	NX_P21359
Orphanet	97685 139474 79428 636 648 3444
PharmGKB	PA31572
eggNOG	prNOG09584
HOGENOM	HBG443611
HOVERGEN	HBG006486
InParanoid	P21359
OMA	FWEISSQ
OrthoDB	EOG4MPHP6
PhylomeDB	P21359
Pathway_Interaction_DB	hnf3bpathway syndecan_2_pathway
NextBio	18348
ArrayExpress	P21359
Bgee	P21359
CleanEx	HS_NF1
Genevestigator	P21359
GermOnline	ENSG00000196712
GO	GO:0030424 GO:0005737 GO:0030425 GO:0031235 GO:0005634 GO:0005515 GO:0005099 GO:0030036 GO:0030325 GO:0048844 GO:0048593 GO:0021987 GO:0030199 GO:0021897 GO:0048853 GO:0007507 GO:0001889 GO:0000165 GO:0001656 GO:0022011 GO:0030336 GO:0001937 GO:0043407 GO:0043409 GO:0007406 GO:0048715 GO:0042992 GO:0001649 GO:0014065 GO:0043473 GO:0045762 GO:0043525 GO:0007265 GO:0043535 GO:0045124 GO:0001952 GO:0001666 GO:0048745 GO:0021510 GO:0048485 GO:0008542 GO:0042060
InterPro	IPR016024 IPR001251 IPR001936 IPR023152 IPR008936
Gene3D	G3DSA:1.10.506.10
KO	K08052
Pfam	PF00616
SMART	SM00323 SM00516
SUPFAM	SSF48371 SSF48350
PROSITE	PS50191 PS00509 PS50018

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000165	MAPKKK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0000165	MAPKKK cascade	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0001649	osteoblast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0001649	osteoblast differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0001656	metanephros development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0001656	metanephros development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0001666	response to hypoxia	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0001889	liver development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0001889	liver development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0001937	negative regulation of endothelial cell proliferation	PMID:16648142^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0001937	negative regulation of endothelial cell proliferation	PMID:17404841^[2]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0001952	regulation of cell-matrix adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0001952	regulation of cell-matrix adhesion	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0001953	negative regulation of cell-matrix adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0005096	GTPase activator activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001936	F	Seeded From UniProt
	GO:0005096	GTPase activator activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0343	F	Seeded From UniProt
	GO:0005096	GTPase activator activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	F	Seeded From UniProt
	GO:0005099	Ras GTPase activator activity	PMID:1568247^[3]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005099	Ras GTPase activator activity	PMID:1570015^[4]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016024	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:11356864^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P34741	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:16374483^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P05067	F	Seeded From UniProt
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001936	C	Seeded From UniProt
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008936	C	Seeded From UniProt
	GO:0005634	nucleus	PMID:1550670^[7]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P97526	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000033		PANTHER:PTHR10194_AN1	C	Seeded From UniProt
	GO:0005737	cytoplasm	PMID:1550670^[7]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P97526	C	Seeded From UniProt
	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0007154	cell communication	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0007154	cell communication	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008936	P	Seeded From UniProt
	GO:0007265	Ras protein signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0007265	Ras protein signal transduction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0007406	negative regulation of neuroblast proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0007406	negative regulation of neuroblast proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0007420	brain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0007420	brain development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0007422	peripheral nervous system development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0007422	peripheral nervous system development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0007507	heart development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0007507	heart development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0007519	skeletal muscle tissue development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0008542	visual learning	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0008542	visual learning	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0014044	Schwann cell development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0014044	Schwann cell development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0014065	phosphatidylinositol 3-kinase cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0014065	phosphatidylinositol 3-kinase cascade	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0016525	negative regulation of angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0021510	spinal cord development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0021510	spinal cord development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0021897	forebrain astrocyte development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0021897	forebrain astrocyte development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0021915	neural tube development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0021987	cerebral cortex development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0021987	cerebral cortex development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0022011	myelination in peripheral nervous system	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0022011	myelination in peripheral nervous system	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0030036	actin cytoskeleton organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0030036	actin cytoskeleton organization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0030198	extracellular matrix organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0030198	extracellular matrix organization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0030199	collagen fibril organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0030199	collagen fibril organization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0030325	adrenal gland development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0030325	adrenal gland development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0030336	negative regulation of cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0030336	negative regulation of cell migration	PMID:16648142^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0030424	axon	PMID:1550670^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0030425	dendrite	PMID:1550670^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0031235	intrinsic to internal side of plasma membrane	GO_REF:0000033		PANTHER:PTHR10194_AN1	C	Seeded From UniProt
	GO:0032228	regulation of synaptic transmission, GABAergic	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0032318	regulation of Ras GTPase activity	PMID:1570015^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0032320	positive regulation of Ras GTPase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0032320	positive regulation of Ras GTPase activity	PMID:1568247^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0032320	positive regulation of Ras GTPase activity	PMID:1570015^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0032320	positive regulation of Ras GTPase activity	PMID:16648142^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0035021	negative regulation of Rac protein signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0042060	wound healing	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0042060	wound healing	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0042127	regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0042992	negative regulation of transcription factor import into nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0042992	negative regulation of transcription factor import into nucleus	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0043065	positive regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0043065	positive regulation of apoptosis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0043409	negative regulation of MAPKKK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0043409	negative regulation of MAPKKK cascade	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0043409	negative regulation of MAPKKK cascade	PMID:16648142^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0043473	pigmentation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0043473	pigmentation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0043525	positive regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0043525	positive regulation of neuron apoptosis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0043535	regulation of blood vessel endothelial cell migration	PMID:17404841^[2]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0043547	positive regulation of GTPase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001936	P	Seeded From UniProt
	GO:0043547	positive regulation of GTPase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0343	P	Seeded From UniProt
	GO:0043547	positive regulation of GTPase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0045124	regulation of bone resorption	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0045124	regulation of bone resorption	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0045671	negative regulation of osteoclast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0045685	regulation of glial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0045685	regulation of glial cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0045762	positive regulation of adenylate cyclase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0045762	positive regulation of adenylate cyclase activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0045765	regulation of angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0045765	regulation of angiogenesis	PMID:17404841^[2]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0046580	negative regulation of Ras protein signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0046580	negative regulation of Ras protein signal transduction	GO_REF:0000033		PANTHER:PTHR10194_AN1	P	Seeded From UniProt
	GO:0046929	negative regulation of neurotransmitter secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0048147	negative regulation of fibroblast proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0048485	sympathetic nervous system development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0048485	sympathetic nervous system development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0048593	camera-type eye morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0048593	camera-type eye morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0048712	negative regulation of astrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0048715	negative regulation of oligodendrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0048715	negative regulation of oligodendrocyte differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0048745	smooth muscle tissue development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0048745	smooth muscle tissue development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0048844	artery morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0048844	artery morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0048853	forebrain morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000071289	P	Seeded From UniProt
	GO:0048853	forebrain morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q04690	P	Seeded From UniProt
	GO:0050890	cognition	PMID:17299016^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0051056	regulation of small GTPase mediated signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001936	P	Seeded From UniProt
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Munchhof AM et al. (2006) Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells. Hum Mol Genet 15: 1858-69 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Thomas SL & De Vries GH (2007) Angiogenic expression profile of normal and neurofibromin-deficient human Schwann cells. Neurochem Res 32: 1129-41 PubMed GONUTS page
↑ ^3.0 ^3.1 Li Y et al. (1992) Somatic mutations in the neurofibromatosis 1 gene in human tumors. Cell 69: 275-81 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Basu TN et al. (1992) Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature 356: 713-5 PubMed GONUTS page
↑ Hsueh YP et al. (2001) Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans. J Neurosci 21: 3764-70 PubMed GONUTS page
↑ De Schepper S et al. (2006) Neurofibromatosis type 1 protein and amyloid precursor protein interact in normal human melanocytes and colocalize with melanosomes. J Invest Dermatol 126: 653-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Daston MM et al. (1992) The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes. Neuron 8: 415-28 PubMed GONUTS page
↑ Hyman SL et al. (2007) T2 hyperintensities in children with neurofibromatosis type 1 and their relationship to cognitive functioning. J Neurol Neurosurg Psychiatry 78: 1088-91 PubMed GONUTS page

[PMID:16648142-0] 1.0 ^1.1 ^1.2 ^1.3 Munchhof AM et al. (2006) Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells. Hum Mol Genet 15: 1858-69 PubMed GONUTS page

[PMID:17404841-1] 2.0 ^2.1 ^2.2 Thomas SL & De Vries GH (2007) Angiogenic expression profile of normal and neurofibromin-deficient human Schwann cells. Neurochem Res 32: 1129-41 PubMed GONUTS page

[PMID:1568247-2] 3.0 ^3.1 Li Y et al. (1992) Somatic mutations in the neurofibromatosis 1 gene in human tumors. Cell 69: 275-81 PubMed GONUTS page

[PMID:1570015-3] 4.0 ^4.1 ^4.2 Basu TN et al. (1992) Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature 356: 713-5 PubMed GONUTS page

[PMID:11356864-4] Hsueh YP et al. (2001) Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans. J Neurosci 21: 3764-70 PubMed GONUTS page

[PMID:16374483-5] De Schepper S et al. (2006) Neurofibromatosis type 1 protein and amyloid precursor protein interact in normal human melanocytes and colocalize with melanosomes. J Invest Dermatol 126: 653-9 PubMed GONUTS page

[PMID:1550670-6] 7.0 ^7.1 ^7.2 ^7.3 Daston MM et al. (1992) The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes. Neuron 8: 415-28 PubMed GONUTS page

[PMID:17299016-7] Hyman SL et al. (2007) T2 hyperintensities in children with neurofibromatosis type 1 and their relationship to cognitive functioning. J Neurol Neurosurg Psychiatry 78: 1088-91 PubMed GONUTS page

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