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HUMAN:NEU1
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | OXT (synonyms: OT) | |
| Protein Name(s) | Oxytocin-neurophysin 1
OT-NPI Oxytocin Ocytocin Neurophysin 1 | |
| External Links | ||
| UniProt | P01178 | |
| EMBL | M25650 M11186 AY082910 AL160414 BC069144 BC101841 BC101843 X03173 M62611 | |
| IPI | IPI00000144 | |
| PIR | A94676 | |
| RefSeq | NP_000906.1 | |
| UniGene | Hs.113216 | |
| ProteinModelPortal | P01178 | |
| SMR | P01178 | |
| IntAct | P01178 | |
| MINT | MINT-7242286 | |
| STRING | P01178 | |
| DMDM | 128071 | |
| PeptideAtlas | P01178 | |
| PRIDE | P01178 | |
| Ensembl | ENST00000217386 | |
| GeneID | 5020 | |
| KEGG | hsa:5020 | |
| UCSC | uc002wht.1 | |
| CTD | 5020 | |
| GeneCards | GC20P003047 | |
| H-InvDB | HIX0040598 | |
| HGNC | HGNC:8528 | |
| MIM | 167050 | |
| neXtProt | NX_P01178 | |
| PharmGKB | PA32857 | |
| eggNOG | prNOG20339 | |
| GeneTree | ENSGT00390000004511 | |
| HOGENOM | HBG446951 | |
| HOVERGEN | HBG004462 | |
| InParanoid | P01178 | |
| OMA | DGCRTDP | |
| OrthoDB | EOG451DS6 | |
| PhylomeDB | P01178 | |
| Reactome | REACT_111102 | |
| DrugBank | DB00107 | |
| NextBio | 19328 | |
| PMAP-CutDB | P01178 | |
| ArrayExpress | P01178 | |
| Bgee | P01178 | |
| CleanEx | HS_OXT | |
| Genevestigator | P01178 | |
| GermOnline | ENSG00000101405 | |
| GO | GO:0005185 GO:0007165 | |
| InterPro | IPR000981 IPR022423 | |
| Gene3D | G3DSA:2.60.9.10 | |
| KO | K05243 | |
| PANTHER | PTHR11681 | |
| Pfam | PF00220 PF00184 | |
| PIRSF | PIRSF001815 | |
| PRINTS | PR00831 | |
| ProDom | PD001676 | |
| SMART | SM00003 | |
| SUPFAM | SSF49606 | |
| PROSITE | PS00264 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001975 |
response to amphetamine |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0002027 |
regulation of heart rate |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0002125 |
maternal aggressive behavior |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0005179 |
hormone activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005184 |
neuropeptide hormone activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
F |
Seeded From UniProt |
|||
| GO:0005185 |
neurohypophyseal hormone activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005185 |
neurohypophyseal hormone activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000028764 |
C |
Seeded From UniProt |
|||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0243 |
C |
Seeded From UniProt |
|||
| GO:0005576 |
extracellular region |
Reactome:REACT_15291 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_16898 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_22263 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_22436 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005615 |
extracellular space |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000028764 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
C |
Seeded From UniProt |
|||
| GO:0006950 |
response to stress |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0007165 |
signal transduction |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007204 |
elevation of cytosolic calcium ion concentration |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0007507 |
heart development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0007565 |
female pregnancy |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0007613 |
memory |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0007625 |
grooming behavior |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0009744 |
response to sucrose stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0010701 |
positive regulation of norepinephrine secretion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0014070 |
response to organic cyclic compound |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0014823 |
response to activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0030141 |
stored secretory granule |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
C |
Seeded From UniProt |
|||
| GO:0030431 |
sleep |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0031855 |
oxytocin receptor binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
F |
Seeded From UniProt |
|||
| GO:0032308 |
positive regulation of prostaglandin secretion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0032355 |
response to estradiol stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0032526 |
response to retinoic acid |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0032570 |
response to progesterone stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0034695 |
response to prostaglandin E stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0035176 |
social behavior |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0035811 |
negative regulation of urine volume |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0035815 |
positive regulation of renal sodium excretion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0042220 |
response to cocaine |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0042538 |
hyperosmotic salinity response |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0042711 |
maternal behavior |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0042713 |
sperm ejaculation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0042755 |
eating behavior |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0042756 |
drinking behavior |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0043195 |
terminal button |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
C |
Seeded From UniProt |
|||
| GO:0043434 |
response to peptide hormone stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0044058 |
regulation of digestive system process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0045472 |
response to ether |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0045776 |
negative regulation of blood pressure |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0045777 |
positive regulation of blood pressure |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0045778 |
positive regulation of ossification |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0045925 |
positive regulation of female receptivity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0048545 |
response to steroid hormone stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0050806 |
positive regulation of synaptic transmission |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0051384 |
response to glucocorticoid stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0051591 |
response to cAMP |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0051602 |
response to electrical stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0051930 |
regulation of sensory perception of pain |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0051965 |
positive regulation of synapse assembly |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0060179 |
male mating behavior |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0060406 |
positive regulation of penile erection |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0060450 |
positive regulation of hindgut contraction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0060455 |
negative regulation of gastric acid secretion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0070474 |
positive regulation of uterine smooth muscle contraction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000028829 |
P |
Seeded From UniProt |
|||
| GO:0035176 |
social behavior |
IDA: Inferred from Direct Assay |
P |
Fig 1, Fig 2 |
complete | |||
| GO:0005179 |
hormone activity |
IDA: Inferred from Direct Assay |
F |
Figure 1 shows oxytocin hormone activity stimulates milk production |
complete | |||
| GO:0005179 |
hormone activity |
IDA: Inferred from Direct Assay |
F |
Figure 1 shows oxytocin hormone activity stimulates pain relief |
complete | |||
| GO:0005179 |
hormone activity |
IDA: Inferred from Direct Assay |
F |
Figure 1 shows oxytocin hormone activity stimulates stress alleviation |
complete | |||
| GO:0042711 |
IDA: Inferred from Direct Assay |
Figure 1 shows oxytocin hormone activity stimulating maternal behavior |
complete | |||||
| GO:0035176 |
IDA: Inferred from Direct Assay |
Figure 1 shows oxytocin hormone activity stimulates social cognition |
complete | |||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Copland JA et al. (1999) Demonstration of functional oxytocin receptors in human breast Hs578T cells and their up-regulation through a protein kinase C-dependent pathway. Endocrinology 140: 2258-67 PubMed GONUTS page
- ↑ Schneiderman I et al. (2012) Oxytocin during the initial stages of romantic attachment: Relations to couples' interactive reciprocity. Psychoneuroendocrinology PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Nagasawa M et al. (2012) Oxytocin and mutual communication in mother-infant bonding. Front Hum Neurosci 6: 31 PubMed GONUTS page
