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HUMAN:NEP
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MME (synonyms: EPN) | |
| Protein Name(s) | Neprilysin
Atriopeptidase Common acute lymphocytic leukemia antigen CALLA Enkephalinase Neutral endopeptidase 24.11 NEP Neutral endopeptidase Skin fibroblast elastase SFE | |
| External Links | ||
| UniProt | P08473 | |
| EMBL | Y00811 J03779 M26628 M26607 M26608 M26609 M26610 M26611 M26612 M26613 M26614 M26615 M26616 M26617 M26618 M26619 M26620 M26621 M26622 M26623 M26624 M26625 M26626 M26627 AK291761 EU326307 CH471052 CH471052 CH471052 CH471052 CH471052 BC101632 BC101658 X07166 | |
| IPI | IPI00247063 | |
| PIR | A41387 | |
| RefSeq | NP_000893.2 NP_009218.2 NP_009219.2 NP_009220.2 | |
| UniGene | Hs.307734 | |
| PDB | 1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 | |
| PDBsum | 1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 | |
| ProteinModelPortal | P08473 | |
| SMR | P08473 | |
| IntAct | P08473 | |
| STRING | P08473 | |
| MEROPS | M13.001 | |
| PhosphoSite | P08473 | |
| DMDM | 128062 | |
| PeptideAtlas | P08473 | |
| PRIDE | P08473 | |
| Ensembl | ENST00000360490 ENST00000404362 ENST00000460393 ENST00000462745 ENST00000492661 ENST00000493237 | |
| GeneID | 4311 | |
| KEGG | hsa:4311 | |
| UCSC | uc003fab.1 | |
| CTD | 4311 | |
| GeneCards | GC03P154741 | |
| H-InvDB | HIX0003792 | |
| HGNC | HGNC:7154 | |
| HPA | CAB000013 | |
| MIM | 120520 | |
| neXtProt | NX_P08473 | |
| PharmGKB | PA30864 | |
| eggNOG | prNOG07698 | |
| GeneTree | ENSGT00550000074200 | |
| HOGENOM | HBG701001 | |
| HOVERGEN | HBG005554 | |
| InParanoid | P08473 | |
| OMA | TYRPEYA | |
| OrthoDB | EOG4XWFXB | |
| PhylomeDB | P08473 | |
| DrugBank | DB00616 | |
| NextBio | 16959 | |
| ArrayExpress | P08473 | |
| Bgee | P08473 | |
| CleanEx | HS_MME | |
| Genevestigator | P08473 | |
| GermOnline | ENSG00000196549 | |
| GO | GO:0005887 GO:0046872 GO:0004222 GO:0005515 GO:0007267 GO:0006508 | |
| InterPro | IPR024079 IPR000718 IPR018497 IPR008753 | |
| Gene3D | G3DSA:3.40.390.10 | |
| KO | K01389 | |
| PANTHER | PTHR11733 | |
| Pfam | PF01431 PF05649 | |
| PRINTS | PR00786 | |
| PROSITE | PS00142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001822 |
kidney development |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0004175 |
endopeptidase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0004175 |
endopeptidase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0004175 |
endopeptidase activity |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0004175 |
endopeptidase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0004222 |
metalloendopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004222 |
metalloendopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004222 |
metalloendopeptidase activity |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005624 |
membrane fraction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000044578 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000044578 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0039 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005887 |
integral to plasma membrane |
NAS: Non-traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005903 |
brush border |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006508 |
proteolysis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006508 |
proteolysis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006508 |
proteolysis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006508 |
proteolysis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006508 |
proteolysis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000044578 |
P |
Seeded From UniProt |
|||
| GO:0006508 |
proteolysis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006508 |
proteolysis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006518 |
peptide metabolic process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000044578 |
P |
Seeded From UniProt |
|||
| GO:0006518 |
peptide metabolic process |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0008021 |
synaptic vesicle |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029400 |
C |
Seeded From UniProt |
|||
| GO:0008021 |
synaptic vesicle |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0008233 |
peptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008233 |
peptidase activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029400 |
F |
Seeded From UniProt |
|||
| GO:0008237 |
metallopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008237 |
metallopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008270 |
zinc ion binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029400 |
C |
Seeded From UniProt |
|||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
NAS: Non-traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0019233 |
sensory perception of pain |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0030424 |
axon |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029400 |
C |
Seeded From UniProt |
|||
| GO:0030424 |
axon |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0030425 |
dendrite |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029400 |
C |
Seeded From UniProt |
|||
| GO:0030425 |
dendrite |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0042277 |
peptide binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000044578 |
F |
Seeded From UniProt |
|||
| GO:0042277 |
peptide binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0044306 |
neuron projection terminus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029400 |
C |
Seeded From UniProt |
|||
| GO:0044306 |
neuron projection terminus |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0045202 |
synapse |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029400 |
C |
Seeded From UniProt |
|||
| GO:0045202 |
synapse |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0046449 |
creatinine metabolic process |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0050435 |
beta-amyloid metabolic process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000029400 |
P |
Seeded From UniProt |
|||
| GO:0050435 |
beta-amyloid metabolic process |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0071345 |
cellular response to cytokine stimulus |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0071492 |
cellular response to UV-A |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0071493 |
cellular response to UV-B |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0090399 |
replicative senescence |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Faa G et al. (2012) CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis. J Matern Fetal Neonatal Med PubMed GONUTS page
- ↑ Rice GI et al. (2004) Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J 383: 45-51 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Morisaki N et al. (2010) Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses. J Biol Chem 285: 39819-27 PubMed GONUTS page
- ↑ Yandle TG et al. (1989) Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126). Peptides 10: 891-4 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Le Moual H et al. (1994) Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11. Eur J Biochem 221: 475-80 PubMed GONUTS page
- ↑ 6.0 6.1 Shipp MA et al. (1989) Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis. Proc Natl Acad Sci U S A 86: 297-301 PubMed GONUTS page
- ↑ 7.0 7.1 Dall'Era MA et al. (2007) HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. Prostate 67: 714-21 PubMed GONUTS page
- ↑ Shipp MA et al. (1988) Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein. Proc Natl Acad Sci U S A 85: 4819-23 PubMed GONUTS page
- ↑ Zhang D et al. (2011) Genetic and functional effects of membrane metalloendopeptidase on diabetic nephropathy development. Am J Nephrol 34: 483-90 PubMed GONUTS page
