HUMAN:NEDD4

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	NEDD4 ( synonyms: KIAA0093, NEDD4-1 )
Protein Name(s)	E3 ubiquitin-protein ligase NEDD4 Cell proliferation-inducing gene 53 protein Neural precursor cell expressed developmentally down-regulated protein 4 NEDD-4
External Links
UniProt Identifier	NEDD4_HUMAN
UniProt Accessions	P46934, A1KY35, A6ND72, A7MD29, B4E2R7, B7ZM59, B7ZM60, B9EGN5, D6RF89,
EMBL	D42055, AK304394, AY550969, AL832063, AC009997, AC039057, CH471082, BC136605, BC144284, BC144285, BC152452, BC152562,
RefSeq	NP_006145.2, NP_940682.2,
PDB	2KPZ, 2KQ0, 2XBB, 2XBF, 3B7Y,
IntAct	P46934,
Ensembl	ENST00000164316, ENST00000338963, ENST00000435532,
Pfam	PF00632, PF00397,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016327	apicolateral plasma membrane		TAS: Traceable Author Statement		C	Source: UniProtKB
	GO:0005938	cell cortex		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0000785	chromatin		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005829	cytosol		ISS: Inferred from Sequence or Structural Similarity		C	Source: UniProtKB
	GO:0005624	membrane fraction		TAS: Traceable Author Statement		C	Source: UniProtKB
	GO:0048471	perinuclear region of cytoplasm		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0000151	ubiquitin ligase complex		ISS: Inferred from Sequence or Structural Similarity		C	Source: UniProtKB
	GO:0031698	beta-2 adrenergic receptor binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0050815	phosphoserine binding		ISS: Inferred from Sequence or Structural Similarity		F	Source: UniProtKB
	GO:0050816	phosphothreonine binding		ISS: Inferred from Sequence or Structural Similarity		F	Source: UniProtKB
	GO:0070064	proline-rich region binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0019904	protein domain specific binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0070063	RNA polymerase binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0019871	sodium channel inhibitor activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0043130	ubiquitin binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0004842	ubiquitin-protein ligase activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0034644	cellular response to UV		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0042921	glucocorticoid receptor signaling pathway		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0052171	growth or development during symbiotic inte...		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0010766	negative regulation of sodium ion transport		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0010768	negative regulation of transcription from R...		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0031175	neurite development		IEP: Inferred from Expression Pattern		P	Source: UniProtKB
	GO:0009405	pathogenesis		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0046824	positive regulation of nucleocytoplasmic tr...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0014068	positive regulation of phosphoinositide 3-k...		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0050847	progesterone receptor signaling pathway		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0006622	protein targeting to lysosome		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0042787	protein ubiquitination during ubiquitin-dep...		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0032801	receptor catabolic process		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0031623	receptor internalization		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0051592	response to calcium ion		TAS: Traceable Author Statement		P	Source: UniProtKB
	GO:0019089	transmission of virus		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB	required field missing
	GO:0000151	ubiquitin ligase complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	C
	GO:0000151	ubiquitin ligase complex	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P46935	C
	GO:0000785	chromatin	PMID:17996703^[1]	IDA: Inferred from Direct Assay		C
	GO:0004842	ubiquitin-protein ligase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	F
	GO:0004842	ubiquitin-protein ligase activity	PMID:17996703^[1]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:10642508^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P37088	F
	GO:0005515	protein binding	PMID:10642508^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P51168	F
	GO:0005515	protein binding	PMID:10642508^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P51170	F
	GO:0005515	protein binding	PMID:12796489^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NV92	F
	GO:0005515	protein binding	PMID:19345329^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P60484	F
	GO:0005515	protein binding	PMID:20086093^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O54967	F
	GO:0005515	protein binding	PMID:20159449^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P10114	F
	GO:0005515	protein binding	PMID:20159449^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UKE5	F
	GO:0005515	protein binding	PMID:20562859^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O95166	F
	GO:0005515	protein binding	PMID:20562859^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P60520	F
	GO:0005515	protein binding	PMID:20562859^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H0R8	F
	GO:0005515	protein binding	PMID:9305852^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q16621	F
	GO:0005515	protein binding	PMID:9990509^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P68036	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	C
	GO:0005624	membrane fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:12796489^[3]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	C
	GO:0005829	cytosol	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P46935	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:15126635^[10]	IMP: Inferred from Mutant Phenotype		C
	GO:0005938	cell cortex	PMID:9990509^[9]	IDA: Inferred from Direct Assay		C
	GO:0006464	protein modification process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	P
	GO:0006622	protein targeting to lysosome	PMID:17116753^[11]	IDA: Inferred from Direct Assay		P
	GO:0007041	lysosomal transport	PMID:18544533^[12]	IDA: Inferred from Direct Assay		P
	GO:0007399	nervous system development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0524	P
	GO:0010766	negative regulation of sodium ion transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	P
	GO:0010766	negative regulation of sodium ion transport	PMID:10642508^[2]	IDA: Inferred from Direct Assay		P
	GO:0010768	negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	PMID:17996703^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	PMID:17218260^[13]	IMP: Inferred from Mutant Phenotype		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016327	apicolateral plasma membrane	PMID:9405440^[14]	TAS: Traceable Author Statement		C
	GO:0016567	protein ubiquitination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	P
	GO:0016567	protein ubiquitination	PMID:17996703^[1]	IDA: Inferred from Direct Assay		P
	GO:0016874	ligase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0436	F
	GO:0016881	acid-amino acid ligase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	F
	GO:0019089	transmission of virus	PMID:15126635^[10]	IMP: Inferred from Mutant Phenotype		P
	GO:0019871	sodium channel inhibitor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	F
	GO:0019871	sodium channel inhibitor activity	PMID:10642508^[2]	IDA: Inferred from Direct Assay		F
	GO:0019904	protein domain specific binding	PMID:12907594^[15]	IPI: Inferred from Physical Interaction	UniProtKB:Q969W9	F
	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	P
	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P46935	P
	GO:0031175	neuron projection development	PMID:9990509^[9]	IEP: Inferred from Expression Pattern		P
	GO:0031623	receptor internalization	PMID:18544533^[12]	IDA: Inferred from Direct Assay		P
	GO:0031698	beta-2 adrenergic receptor binding	PMID:18544533^[12]	IDA: Inferred from Direct Assay		F
	GO:0032801	receptor catabolic process	PMID:18544533^[12]	IDA: Inferred from Direct Assay		P
	GO:0034644	cellular response to UV	PMID:17996703^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	PMID:17218260^[13]	IMP: Inferred from Mutant Phenotype		P
	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	PMID:17996703^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0042921	glucocorticoid receptor signaling pathway	PMID:8649367^[16]	IDA: Inferred from Direct Assay		P
	GO:0043130	ubiquitin binding	PMID:9990509^[9]	IDA: Inferred from Direct Assay		F
	GO:0044111	development involved in symbiotic interaction	PMID:15126635^[10]	IMP: Inferred from Mutant Phenotype		P
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P
	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	P
	GO:0045732	positive regulation of protein catabolic process	PMID:14973438^[17]	IDA: Inferred from Direct Assay		P
	GO:0046824	positive regulation of nucleocytoplasmic transport	PMID:17218261^[18]	IDA: Inferred from Direct Assay		P
	GO:0048471	perinuclear region of cytoplasm	PMID:9990509^[9]	IDA: Inferred from Direct Assay		C
	GO:0048814	regulation of dendrite morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	P
	GO:0048814	regulation of dendrite morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P46935	P
	GO:0050815	phosphoserine binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	F
	GO:0050815	phosphoserine binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P46935	F
	GO:0050816	phosphothreonine binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	F
	GO:0050816	phosphothreonine binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P46935	F
	GO:0050847	progesterone receptor signaling pathway	PMID:8649367^[16]	IDA: Inferred from Direct Assay		P
	GO:0051592	response to calcium ion	PMID:9405440^[14]	TAS: Traceable Author Statement		P
	GO:0070063	RNA polymerase binding	PMID:17996703^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P24928	F
	GO:0070064	proline-rich region binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034740	F
	GO:0070064	proline-rich region binding	PMID:11342538^[19]	IPI: Inferred from Physical Interaction	UniProtKB:Q15038	F
	GO:0070064	proline-rich region binding	PMID:15126635^[10]	IMP: Inferred from Mutant Phenotype		F
	GO:0070534	protein K63-linked ubiquitination	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q62940	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Anindya R et al. (2007) Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1. Mol Cell 28: 386-97 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Farr TJ et al. (2000) Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits. Biochem J 345 Pt 3: 503-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Cristillo AD et al. (2003) Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes. J Biol Chem 278: 34587-97 PubMed GONUTS page
↑ Yim EK et al. (2009) Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell 15: 304-14 PubMed GONUTS page
↑ Lin Q et al. (2010) HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol 30: 1541-54 PubMed GONUTS page
↑ ^6.0 ^6.1 Kawabe H et al. (2010) Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron 65: 358-72 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Behrends C et al. (2010) Network organization of the human autophagy system. Nature 466: 68-76 PubMed GONUTS page
↑ Gavva NR et al. (1997) Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II. J Biol Chem 272: 24105-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Anan T et al. (1998) Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Genes Cells 3: 751-63 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Blot V et al. (2004) Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding. J Cell Sci 117: 2357-67 PubMed GONUTS page
↑ Pak Y et al. (2006) Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. J Cell Biol 175: 631-45 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Shenoy SK et al. (2008) Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J Biol Chem 283: 22166-76 PubMed GONUTS page
↑ ^13.0 ^13.1 Wang X et al. (2007) NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128: 129-39 PubMed GONUTS page
↑ ^14.0 ^14.1 Plant PJ et al. (1997) The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization. J Biol Chem 272: 32329-36 PubMed GONUTS page
↑ Xu LL et al. (2003) PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. Cancer Res 63: 4299-304 PubMed GONUTS page
↑ ^16.0 ^16.1 Imhof MO & McDonnell DP (1996) Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. Mol Cell Biol 16: 2594-605 PubMed GONUTS page
↑ Heissmeyer V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol 5: 255-65 PubMed GONUTS page
↑ Trotman LC et al. (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128: 141-56 PubMed GONUTS page
↑ Hamilton MH et al. (2001) Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. J Biol Chem 276: 26324-31 PubMed GONUTS page

[PMID:17996703-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Anindya R et al. (2007) Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1. Mol Cell 28: 386-97 PubMed GONUTS page

[PMID:10642508-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Farr TJ et al. (2000) Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits. Biochem J 345 Pt 3: 503-9 PubMed GONUTS page

[PMID:12796489-2] 3.0 ^3.1 Cristillo AD et al. (2003) Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes. J Biol Chem 278: 34587-97 PubMed GONUTS page

[PMID:19345329-3] Yim EK et al. (2009) Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell 15: 304-14 PubMed GONUTS page

[PMID:20086093-4] Lin Q et al. (2010) HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol 30: 1541-54 PubMed GONUTS page

[PMID:20159449-5] 6.0 ^6.1 Kawabe H et al. (2010) Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron 65: 358-72 PubMed GONUTS page

[PMID:20562859-6] 7.0 ^7.1 ^7.2 Behrends C et al. (2010) Network organization of the human autophagy system. Nature 466: 68-76 PubMed GONUTS page

[PMID:9305852-7] Gavva NR et al. (1997) Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II. J Biol Chem 272: 24105-8 PubMed GONUTS page

[PMID:9990509-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Anan T et al. (1998) Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Genes Cells 3: 751-63 PubMed GONUTS page

[PMID:15126635-9] 10.0 ^10.1 ^10.2 ^10.3 Blot V et al. (2004) Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding. J Cell Sci 117: 2357-67 PubMed GONUTS page

[PMID:17116753-10] Pak Y et al. (2006) Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. J Cell Biol 175: 631-45 PubMed GONUTS page

[PMID:18544533-11] 12.0 ^12.1 ^12.2 ^12.3 Shenoy SK et al. (2008) Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J Biol Chem 283: 22166-76 PubMed GONUTS page

[PMID:17218260-12] 13.0 ^13.1 Wang X et al. (2007) NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128: 129-39 PubMed GONUTS page

[PMID:9405440-13] 14.0 ^14.1 Plant PJ et al. (1997) The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization. J Biol Chem 272: 32329-36 PubMed GONUTS page

[PMID:12907594-14] Xu LL et al. (2003) PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. Cancer Res 63: 4299-304 PubMed GONUTS page

[PMID:8649367-15] 16.0 ^16.1 Imhof MO & McDonnell DP (1996) Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. Mol Cell Biol 16: 2594-605 PubMed GONUTS page

[PMID:14973438-16] Heissmeyer V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol 5: 255-65 PubMed GONUTS page

[PMID:17218261-17] Trotman LC et al. (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128: 141-56 PubMed GONUTS page

[PMID:11342538-18] Hamilton MH et al. (2001) Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. J Biol Chem 276: 26324-31 PubMed GONUTS page

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HUMAN:NEDD4

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