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HUMAN:NCF1

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Contents

Species (Taxon ID) Homo sapiens (Human). (taxon:9606)
Gene Name(s) NCF1 ( synonyms: NOXO2, SH3PXD1A )
Protein Name(s)
  • Neutrophil cytosol factor 1
  • NCF-1
  • 47 kDa autosomal chronic granulomatous disease protein
  • 47 kDa neutrophil oxidase factor
  • NCF-47K
  • Neutrophil NADPH oxidase factor 1
  • Nox organizer 2
  • Nox-organizing protein 2
  • SH3 and PX domain-containing protein 1A
  • p47-phox
External Links
UniProt Identifier NCF1_HUMAN
UniProt Accessions P14598, A6NEH2, A8K7S9, O43842, Q2PP07, Q53FR5, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2,
EMBL M25665, M55067, U57835, U57833, U57834, AF184614, AF330625, AF330626, AF330627, AK127905, AK292094, AK223217, AC004883, AC083884, AC124781, BC002816, BC065731, U25793, DQ314878,
PIR A35926,
RefSeq NP_000256.3,
PDB 1GD5, 1K4U, 1KQ6, 1NG2, 1O7K, 1OV3, 1UEC, 1W70, 1WLP,
IntAct P14598,
Ensembl ENST00000289473,
Pfam PF08944, PF00787, PF00018,



Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003924

GTPase activity

PMID:2547247[1]

TAS: Traceable Author Statement

F

GO:0005515

protein binding

PMID:11094157[2]

IPI: Inferred from Physical Interaction

UniProtKB:P31146

F

GO:0005515

protein binding

PMID:11733522[3]

IPI: Inferred from Physical Interaction

UniProtKB:P13498

F

GO:0005515

protein binding

PMID:12681507[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q8IZP0

F

GO:0005515

protein binding

PMID:16326715[5]

IPI: Inferred from Physical Interaction

UniProtKB:P13498

F

GO:0005525

GTP binding

PMID:2848318[6]

TAS: Traceable Author Statement

F

GO:0005625

soluble fraction

PMID:2848318[6]

TAS: Traceable Author Statement

C

GO:0005737

cytoplasm

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001655

C

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

GO:0005829

cytosol

PMID:2848318[6]

TAS: Traceable Author Statement

C

GO:0006184

GTP catabolic process

PMID:2547247[1]

TAS: Traceable Author Statement

P

GO:0006612

protein targeting to membrane

PMID:12356722[7]

IDA: Inferred from Direct Assay

P

GO:0006801

superoxide metabolic process

PMID:7938008[8]

TAS: Traceable Author Statement

P

GO:0006968

cellular defense response

PMID:2848318[6]

TAS: Traceable Author Statement

P

GO:0007154

cell communication

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001683

P

GO:0009055

electron carrier activity

PMID:2848318[6]

TAS: Traceable Author Statement

F

GO:0016175

superoxide-generating NADPH oxidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001655

F

GO:0017124

SH3 domain binding

PMID:7938008[8]

IPI: Inferred from Physical Interaction

UniProtKB:P14598

F

GO:0017124

SH3 domain binding

PMID:7938008[8]

IPI: Inferred from Physical Interaction

UniProtKB:P19878

F

GO:0035091

phosphatidylinositol binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001683

F

GO:0035091

phosphatidylinositol binding

PMID:12356722[7]

IDA: Inferred from Direct Assay

F

GO:0042554

superoxide anion generation

PMID:7938008[8]

TAS: Traceable Author Statement

P

GO:0043020

NADPH oxidase complex

PMID:7938008[8]

TAS: Traceable Author Statement

C

GO:0045087

innate immune response

PMID:7938008[8]

TAS: Traceable Author Statement

P

GO:0045730

respiratory burst

PMID:7938008[8]

TAS: Traceable Author Statement

P


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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Lomax KJ et al. (1989) Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease. Science 245: 409-12 PubMed GONUTS page
  2. ↑ Didichenko SA et al. (2000) Evidence for a pool of coronin in mammalian cells that is sensitive to PI 3-kinase. FEBS Lett 485: 147-52 PubMed GONUTS page
  3. ↑ Dahan I et al. (2002) Mapping of functional domains in the p22(phox) subunit of flavocytochrome b(559) participating in the assembly of the NADPH oxidase complex by "peptide walking". J Biol Chem 277: 8421-32 PubMed GONUTS page
  4. ↑ Gu Y et al. (2003) Induction of colonic epithelial cell apoptosis by p47-dependent oxidants. FEBS Lett 540: 195-200 PubMed GONUTS page
  5. ↑ Ogura K et al. (2006) NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide. J Biol Chem 281: 3660-8 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Volpp BD et al. (1988) Two cytosolic neutrophil oxidase components absent in autosomal chronic granulomatous disease. Science 242: 1295-7 PubMed GONUTS page
  7. ↑ 7.0 7.1 Karathanassis D et al. (2002) Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction. EMBO J 21: 5057-68 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Leto TL et al. (1994) Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets. Proc Natl Acad Sci U S A 91: 10650-4 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/HUMAN:NCF1"
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