HUMAN:NB5R3

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	CYB5R3 ( synonyms: DIA1 )
Protein Name(s)	NADH-cytochrome b5 reductase 3 B5R Cytochrome b5 reductase Diaphorase-1 NADH-cytochrome b5 reductase 3 membrane-bound form NADH-cytochrome b5 reductase 3 soluble form
External Links
UniProt Identifier	NB5R3_HUMAN
UniProt Accessions	P00387, B1AHF2, O75675, Q8TDL8, Q8WTS8, Q9UEN4, Q9UEN5, Q9UL55, Q9UL56,
EMBL	M28713, M28705, M28706, M28707, M28708, M28709, M28710, M28711, Y09501, AF361370, AJ010116, AJ010117, AJ010118, BT009821, CR456435, AY341030, AF061830, AF061831, BC004821, Z93241, Z93241, AJ310899, AJ310900, M16461, M16462,
PIR	JS0468,
RefSeq	NP_000389.1, NP_001123291.1, NP_001165132.1, NP_015565.1,
PDB	1M91, 1UMK,
IntAct	P00387,
Ensembl	ENST00000352397,
Pfam	PF00970, PF00175,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0004128	cytochrome-b5 reductase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.6.2.2	F
	GO:0004128	cytochrome-b5 reductase activity	PMID:1400360^[1]	TAS: Traceable Author Statement		F
	GO:0004128	cytochrome-b5 reductase activity	Reactome:REACT_11182	TAS: Traceable Author Statement		F
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:9207238^[2]	TAS: Traceable Author Statement		C
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0005741	mitochondrial outer membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1000	C
	GO:0005741	mitochondrial outer membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0172	C
	GO:0005741	mitochondrial outer membrane	Reactome:REACT_11182	TAS: Traceable Author Statement		C
	GO:0005783	endoplasmic reticulum	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0256	C
	GO:0005783	endoplasmic reticulum	PMID:18029348^[3]	IDA: Inferred from Direct Assay		C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0097	C
	GO:0005833	hemoglobin complex	PMID:1400360^[1]	TAS: Traceable Author Statement		C
	GO:0006694	steroid biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0752	P
	GO:0006695	cholesterol biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0152	P
	GO:0006766	vitamin metabolic process	Reactome:REACT_11193	TAS: Traceable Author Statement		P
	GO:0006767	water-soluble vitamin metabolic process	Reactome:REACT_11238	TAS: Traceable Author Statement		P
	GO:0008015	blood circulation	PMID:1400360^[1]	TAS: Traceable Author Statement		P
	GO:0008610	lipid biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0444	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	PMID:9207238^[2]	TAS: Traceable Author Statement		C
	GO:0016126	sterol biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0756	P
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001433	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001709	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001834	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008333	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017927	F
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001433	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001709	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001834	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008333	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017927	P
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P
	GO:0004128	cytochrome-b5 reductase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.6.2.2	F
	GO:0004128	cytochrome-b5 reductase activity	PMID:1400360^[1]	TAS: Traceable Author Statement		F
	GO:0004128	cytochrome-b5 reductase activity	Reactome:REACT_11182	TAS: Traceable Author Statement		F
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:9207238^[2]	TAS: Traceable Author Statement		C
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0005741	mitochondrial outer membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1000	C
	GO:0005741	mitochondrial outer membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0172	C
	GO:0005741	mitochondrial outer membrane	Reactome:REACT_11182	TAS: Traceable Author Statement		C
	GO:0005743	mitochondrial inner membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000018186	C
	GO:0005783	endoplasmic reticulum	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0256	C
	GO:0005783	endoplasmic reticulum	PMID:18029348^[3]	IDA: Inferred from Direct Assay		C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0097	C
	GO:0005833	hemoglobin complex	PMID:1400360^[1]	TAS: Traceable Author Statement		C
	GO:0006694	steroid biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0752	P
	GO:0006695	cholesterol biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0152	P
	GO:0006766	vitamin metabolic process	Reactome:REACT_11193	TAS: Traceable Author Statement		P
	GO:0006767	water-soluble vitamin metabolic process	Reactome:REACT_11238	TAS: Traceable Author Statement		P
	GO:0008015	blood circulation	PMID:1400360^[1]	TAS: Traceable Author Statement		P
	GO:0008610	lipid biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0444	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	PMID:9207238^[2]	TAS: Traceable Author Statement		C
	GO:0016126	sterol biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0756	P
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001433	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001709	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001834	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017927	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017938	F
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001433	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001709	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001834	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017927	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017938	P
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Shirabe K et al. (1992) Enzymatic instability of NADH-cytochrome b5 reductase as a cause of hereditary methemoglobinemia type I (red cell type). J Biol Chem 267: 20416-21 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Du M et al. (1997) Identification of alternative first exons of NADH-cytochrome b5 reductase gene expressed ubiquitously in human cells. Biochem Biophys Res Commun 235: 779-83 PubMed GONUTS page
↑ ^3.0 ^3.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:1400360-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Shirabe K et al. (1992) Enzymatic instability of NADH-cytochrome b5 reductase as a cause of hereditary methemoglobinemia type I (red cell type). J Biol Chem 267: 20416-21 PubMed GONUTS page

[PMID:9207238-1] 2.0 ^2.1 ^2.2 ^2.3 Du M et al. (1997) Identification of alternative first exons of NADH-cytochrome b5 reductase gene expressed ubiquitously in human cells. Biochem Biophys Res Commun 235: 779-83 PubMed GONUTS page

[PMID:18029348-2] 3.0 ^3.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

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HUMAN:NB5R3

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