HUMAN:NALP1

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	NLRP1 ( synonyms: CARD7, DEFCAP, KIAA0926, NAC, NALP1 )
Protein Name(s)	NACHT, LRR and PYD domains-containing protein 1 Caspase recruitment domain-containing protein 7 Death effector filament-forming ced-4-like apoptosis protein Nucleotide-binding domain and caspase recruitment domain
External Links
UniProt Identifier	NALP1_HUMAN
UniProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0,
EMBL	AF298548, AF310105, AF229059, AF229060, AF229061, AF229062, AB023143, AL117470,
PIR	T17255,
RefSeq	NP_001028225.1, NP_055737.1, NP_127497.1, NP_127499.1, NP_127500.1,
PDB	1PN5, 3KAT,
IntAct	Q9C000,
Ensembl	ENST00000269280,
Pfam	PF00619, PF00560, PF02758,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0051402	neuron apoptosis	PMID:15212762^[1]	IDA: Inferred from Direct Assay		P
	GO:0019904	protein domain specific binding	PMID:16575408^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O95361	F
	GO:0050727	regulation of inflammatory response	PMID:15212762^[1]	IC: Inferred by Curator	GO:0006919	P
	GO:0005515	protein binding	PMID:19337385^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HC29	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	C
	GO:0005515	protein binding	PMID:17418785^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P29466	F
	GO:0005515	protein binding	PMID:17418785^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q07817	F
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0005634	nucleus	PMID:17164409^[5]	IDA: Inferred from Direct Assay		C
	GO:0006919	activation of caspase activity	PMID:11076957^[6]	NAS: Non-traceable Author Statement		P
	GO:0005515	protein binding	PMID:17418785^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P51878	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0032495	response to muramyl dipeptide	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q67EY4	P
	GO:0006952	defense response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000767	P
	GO:0005515	protein binding	PMID:17418785^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P10415	F
	GO:0005524	ATP binding	PMID:15212762^[1]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:11472070^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPP4	F
	GO:0005515	protein binding	PMID:15107016^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPP4	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0042742	defense response to bacterium	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q67EY4	P
	GO:0008656	caspase activator activity	PMID:11076957^[6]	NAS: Non-traceable Author Statement		F
	GO:0019899	enzyme binding	PMID:11076957^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P42575	F
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0006917	induction of apoptosis	PMID:15212762^[1]	IDA: Inferred from Direct Assay		P
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005515	protein binding	PMID:17418785^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9ULZ3	F
	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q67EY4	P
	GO:0005515	protein binding	PMID:15107016^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P29466	F
	GO:0005622	intracellular	PMID:11076957^[6]	IC: Inferred by Curator	GO:0019899	C
	GO:0006919	activation of caspase activity	PMID:15212762^[1]	IDA: Inferred from Direct Assay		P
	GO:0006917	induction of apoptosis	PMID:11076957^[6]	NAS: Non-traceable Author Statement		P
	GO:0072558	NALP1 inflammasome complex	PMID:20303873^[9]	TAS: Traceable Author Statement		C
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0002218	activation of innate immune response	Reactome:REACT_75913	TAS: Traceable Author Statement		P
	GO:0005515	protein binding	PMID:11472070^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPP4	F
	GO:0005515	protein binding	PMID:15107016^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P29466	F
	GO:0005515	protein binding	PMID:15107016^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPP4	F
	GO:0005515	protein binding	PMID:17418785^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P10415	F
	GO:0005515	protein binding	PMID:17418785^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P29466	F
	GO:0005515	protein binding	PMID:17418785^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P51878	F
	GO:0005515	protein binding	PMID:17418785^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q07817	F
	GO:0005515	protein binding	PMID:17418785^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9ULZ3	F
	GO:0005515	protein binding	PMID:19337385^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HC29	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005524	ATP binding	PMID:15212762^[1]	IDA: Inferred from Direct Assay		F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	C
	GO:0005622	intracellular	PMID:11076957^[6]	IC: Inferred by Curator	GO:0019899	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:17164409^[5]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005829	cytosol	Reactome:REACT_75756	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75818	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75844	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_75872	TAS: Traceable Author Statement		C
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006917	induction of apoptosis	PMID:11076957^[6]	NAS: Non-traceable Author Statement		P
	GO:0006917	induction of apoptosis	PMID:15212762^[1]	IDA: Inferred from Direct Assay		P
	GO:0006919	activation of caspase activity	PMID:11076957^[6]	NAS: Non-traceable Author Statement		P
	GO:0006919	activation of caspase activity	PMID:15212762^[1]	IDA: Inferred from Direct Assay		P
	GO:0006952	defense response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000767	P
	GO:0008656	caspase activator activity	PMID:11076957^[6]	NAS: Non-traceable Author Statement		F
	GO:0019899	enzyme binding	PMID:11076957^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P42575	F
	GO:0019904	protein domain specific binding	PMID:16575408^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O95361	F
	GO:0032495	response to muramyl dipeptide	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q67EY4	P
	GO:0042742	defense response to bacterium	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q67EY4	P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	P
	GO:0045087	innate immune response	Reactome:REACT_6802	TAS: Traceable Author Statement		P
	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q67EY4	P
	GO:0050727	regulation of inflammatory response	PMID:15212762^[1]	IC: Inferred by Curator	GO:0006919	P
	GO:0051402	neuron apoptosis	PMID:15212762^[1]	IDA: Inferred from Direct Assay		P
	GO:0072558	NALP1 inflammasome complex	PMID:20303873^[9]	TAS: Traceable Author Statement		C
	GO:0019904		PMID:15285719^[10]	IDA: Inferred from Direct Assay			Figure 1A and Figure 1B	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Liu F et al. (2004) Expression of NALP1 in cerebellar granule neurons stimulates apoptosis. Cell Signal 16: 1013-21 PubMed GONUTS page
↑ ^2.0 ^2.1 Munding C et al. (2006) The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion. Cell Death Differ 13: 1938-49 PubMed GONUTS page
↑ ^3.0 ^3.1 Wagner RN et al. (2009) Evaluation of Nod-like receptor (NLR) effector domain interactions. PLoS One 4: e4931 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Bruey JM et al. (2007) Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell 129: 45-56 PubMed GONUTS page
↑ ^5.0 ^5.1 Kummer JA et al. (2007) Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem 55: 443-52 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Hlaing T et al. (2001) Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J Biol Chem 276: 9230-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Damiano JS et al. (2001) CLAN, a novel human CED-4-like gene. Genomics 75: 77-83 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Damiano JS et al. (2004) Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem J 381: 213-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Schroder K & Tschopp J (2010) The inflammasomes. Cell 140: 821-32 PubMed GONUTS page
↑ Sanz C et al. (2004) NALP1 is a transcriptional target for cAMP-response-element-binding protein (CREB) in myeloid leukaemia cells. Biochem J 384: 281-6 PubMed GONUTS page

[PMID:15212762-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Liu F et al. (2004) Expression of NALP1 in cerebellar granule neurons stimulates apoptosis. Cell Signal 16: 1013-21 PubMed GONUTS page

[PMID:16575408-1] 2.0 ^2.1 Munding C et al. (2006) The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion. Cell Death Differ 13: 1938-49 PubMed GONUTS page

[PMID:19337385-2] 3.0 ^3.1 Wagner RN et al. (2009) Evaluation of Nod-like receptor (NLR) effector domain interactions. PLoS One 4: e4931 PubMed GONUTS page

[PMID:17418785-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Bruey JM et al. (2007) Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell 129: 45-56 PubMed GONUTS page

[PMID:17164409-4] 5.0 ^5.1 Kummer JA et al. (2007) Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem 55: 443-52 PubMed GONUTS page

[PMID:11076957-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Hlaing T et al. (2001) Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J Biol Chem 276: 9230-8 PubMed GONUTS page

[PMID:11472070-6] 7.0 ^7.1 Damiano JS et al. (2001) CLAN, a novel human CED-4-like gene. Genomics 75: 77-83 PubMed GONUTS page

[PMID:15107016-7] 8.0 ^8.1 ^8.2 ^8.3 Damiano JS et al. (2004) Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem J 381: 213-9 PubMed GONUTS page

[PMID:20303873-8] 9.0 ^9.1 Schroder K & Tschopp J (2010) The inflammasomes. Cell 140: 821-32 PubMed GONUTS page

[PMID:15285719-9] Sanz C et al. (2004) NALP1 is a transcriptional target for cAMP-response-element-binding protein (CREB) in myeloid leukaemia cells. Biochem J 384: 281-6 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

HUMAN:NALP1

Contents

Annotations

Notes

References

a

c

d

d cont.

e

i

n

n cont.

p

r

s

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox