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HUMAN:MYLK
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (taxon:9606) | |
| Gene Name(s) | MYLK ( synonyms: MLCK ) | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | MYLK_HUMAN | |
| UniProt Accessions | Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9, | |
| EMBL | X85337, U48959, AF069601, AF069602, AF069603, AF069604, AY424269, AY424270, AY339601, AB037663, X90870, AC020634, AC023165, AF096771, AF096766, AF096767, AF096768, AF096769, AF096770, AF096771, AF096769, AF096770, AF096774, | |
| RefSeq | NP_444253.3, NP_444254.3, NP_444255.3, NP_444256.3, NP_444259.1, | |
| PDB | 2CQV, 2K0F, 2YR3, | |
| IntAct | Q15746, | |
| Ensembl | ENST00000360304, ENST00000361290, ENST00000475616, | |
| Pfam | PF00041, PF07679, PF00069, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005829 |
cytosol |
EXP: Inferred from Experiment |
C |
Source: Reactome |
||||
| GO:0003779 |
actin binding |
IEA: Inferred from Electronic Annotation |
F |
Source: UniProtKB-KW |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Source: UniProtKB-KW |
||||
| GO:0005516 |
calmodulin binding |
IEA: Inferred from Electronic Annotation |
F |
Source: UniProtKB-KW |
||||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Source: UniProtKB-KW |
||||
| GO:0004687 |
myosin light chain kinase activity |
TAS: Traceable Author Statement |
F |
Source: ProtInc |
||||
| GO:0006936 |
muscle contraction |
EXP: Inferred from Experiment |
P |
Source: Reactome |
||||
| GO:0006468 |
protein amino acid phosphorylation |
TAS: Traceable Author Statement |
P |
Source: ProtInc |
||||
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003779 |
actin binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0004687 |
myosin light chain kinase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0004687 |
myosin light chain kinase activity |
TAS: Traceable Author Statement |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005516 |
calmodulin binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0005829 |
cytosol |
Reactome:REACT_20521 |
TAS: Traceable Author Statement |
C |
||||
| GO:0005829 |
cytosol |
Reactome:REACT_20597 |
TAS: Traceable Author Statement |
C |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006468 |
protein phosphorylation |
TAS: Traceable Author Statement |
P |
|||||
| GO:0006936 |
muscle contraction |
Reactome:REACT_20558 |
TAS: Traceable Author Statement |
P |
||||
| GO:0016301 |
kinase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0016310 |
phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0060414 |
aorta smooth muscle tissue morphogenesis |
IMP: Inferred from Mutant Phenotype |
P |
| ||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Potier MC et al. (1995) The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21. Genomics 29: 562-70 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Wu C et al. (2007) Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Proteomics 7: 1775-85 PubMed GONUTS page
- ↑ Wang L et al. (2010) Mutations in myosin light chain kinase cause familial aortic dissections. Am J Hum Genet 87: 701-7 PubMed GONUTS page
