HUMAN:MYC

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	MYC ( synonyms: BHLHE39 )
Protein Name(s)	Myc proto-oncogene protein Class E basic helix-loop-helix protein 39 bHLHe39 Proto-oncogene c-Myc Transcription factor p64
External Links
UniProt Identifier	MYC_HUMAN
UniProt Accessions	P01106, A8WFE7, P01107, Q14026,
EMBL	L00058, L00057, K00535, K00534, K00535, K00534, X00196, X00198, X00364, V00568, K01906, K01905, K02276, X00676, D10493, D10493, BT019768, AY214166, AK312883, AC103819, CH471060, BC000141, BC000917, BC058901, M13929,
PIR	A01349, A01350,
RefSeq	NP_002458.2,
PDB	1A93, 1EE4, 1MV0, 1NKP, 2A93,
IntAct	P01106,
Ensembl	ENST00000377970,
Pfam	PF00010, PF02344, PF01056,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01108	P
	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01108	P
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	PMID:10597290^[1]	TAS: Traceable Author Statement		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002418	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003327	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012682	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:9924025^[2]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:10597290^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q13287	F
	GO:0005515	protein binding	PMID:11891322^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P52164	F
	GO:0005515	protein binding	PMID:12706874^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IY57	F
	GO:0005515	protein binding	PMID:15103331^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q969H0	F
	GO:0005515	protein binding	PMID:16352593^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q13105	F
	GO:0005515	protein binding	PMID:17157259^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q09472	F
	GO:0005515	protein binding	PMID:17157259^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q13309	F
	GO:0005515	protein binding	PMID:17157259^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TAD8	F
	GO:0005515	protein binding	PMID:17157259^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q969H0	F
	GO:0005515	protein binding	PMID:17314511^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P03070	F
	GO:0005515	protein binding	PMID:17314511^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q14839	F
	GO:0005515	protein binding	PMID:17314511^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N3Y1	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:O43795	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:O75643	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P07910	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P33993	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P51532	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P52701	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P57678	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P61244	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q07864	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q15029	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q29RF7	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q6P2Q9	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N163	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N1F7	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N6R0	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q92621	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q92974	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q96A65	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BQG0	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9GZR7	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H583	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NVI1	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UL63	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y5Q9	F
	GO:0005515	protein binding	PMID:17418410^[10]	IPI: Inferred from Physical Interaction	UniProtKB:O75928	F
	GO:0005515	protein binding	PMID:17418410^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P08047	F
	GO:0005515	protein binding	PMID:17632056^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TCG1	F
	GO:0005515	protein binding	PMID:17728244^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9DUN1	F
	GO:0005515	protein binding	PMID:20195357^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q15059	F
	GO:0005515	protein binding	PMID:20195357^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q86XR8	F
	GO:0005515	protein binding	PMID:20551172^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TEL6	F
	GO:0005515	protein binding	PMID:20691906^[15]	IPI: Inferred from Physical Interaction	UniProtKB:Q2T9S0	F
	GO:0005515	protein binding	PMID:9308237^[16]	IPI: Inferred from Physical Interaction	UniProtKB:Q13105	F
	GO:0005515	protein binding	PMID:9708738^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4A5	F
	GO:0005515	protein binding	PMID:9708738^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4A5	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002418	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003327	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012682	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	PMID:11793365^[18]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:15994933^[19]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:9187264^[20]	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0190	C
	GO:0005654	nucleoplasm	PMID:17558397^[21]	IDA: Inferred from Direct Assay		C
	GO:0005730	nucleolus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0188	C
	GO:0005730	nucleolus	PMID:17558397^[21]	IDA: Inferred from Direct Assay		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:9924025^[2]	TAS: Traceable Author Statement		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002418	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003327	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012682	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006357	regulation of transcription from RNA polymerase II promoter	PMID:9924025^[2]	TAS: Traceable Author Statement		P
	GO:0006879	cellular iron ion homeostasis	PMID:9924025^[2]	TAS: Traceable Author Statement		P
	GO:0007050	cell cycle arrest	PMID:10962037^[22]	TAS: Traceable Author Statement		P
	GO:0008283	cell proliferation	PMID:10962037^[22]	TAS: Traceable Author Statement		P
	GO:0008284	positive regulation of cell proliferation	PMID:15994933^[19]	IDA: Inferred from Direct Assay		P
	GO:0016563	transcription activator activity	PMID:17558397^[21]	IDA: Inferred from Direct Assay		F
	GO:0016563	transcription activator activity	PMID:18818310^[23]	IDA: Inferred from Direct Assay		F
	GO:0030528	transcription regulator activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001092	F
	GO:0030528	transcription regulator activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	F
	GO:0032204	regulation of telomere maintenance	PMID:17765874^[24]	IMP: Inferred from Mutant Phenotype		P
	GO:0042493	response to drug	PMID:18291362^[25]	IEP: Inferred from Expression Pattern		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:17558397^[21]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:18818310^[23]	IDA: Inferred from Direct Assay		P
	GO:0070888	E-box binding	PMID:18818310^[23]	IDA: Inferred from Direct Assay		F
	GO:0090096	positive regulation of metanephric cap mesenchymal cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01108	P
	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01108	P
	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01108	P
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	PMID:10597290^[1]	TAS: Traceable Author Statement		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002418	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003327	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012682	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:9924025^[2]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:10597290^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q13287	F
	GO:0005515	protein binding	PMID:11891322^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P52164	F
	GO:0005515	protein binding	PMID:12706874^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IY57	F
	GO:0005515	protein binding	PMID:15103331^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q969H0	F
	GO:0005515	protein binding	PMID:16352593^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q13105	F
	GO:0005515	protein binding	PMID:17157259^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q09472	F
	GO:0005515	protein binding	PMID:17157259^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q13309	F
	GO:0005515	protein binding	PMID:17157259^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TAD8	F
	GO:0005515	protein binding	PMID:17157259^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q969H0	F
	GO:0005515	protein binding	PMID:17314511^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P03070	F
	GO:0005515	protein binding	PMID:17314511^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q14839	F
	GO:0005515	protein binding	PMID:17314511^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N3Y1	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:O43795	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:O75643	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P07910	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P33993	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P51532	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P52701	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P57678	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P61244	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q07864	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q15029	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q29RF7	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q6P2Q9	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N163	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N1F7	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q8N6R0	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q92621	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q92974	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q96A65	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BQG0	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9GZR7	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H583	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NVI1	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UL63	F
	GO:0005515	protein binding	PMID:17353931^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y5Q9	F
	GO:0005515	protein binding	PMID:17418410^[10]	IPI: Inferred from Physical Interaction	UniProtKB:O75928	F
	GO:0005515	protein binding	PMID:17418410^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P08047	F
	GO:0005515	protein binding	PMID:17632056^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TCG1	F
	GO:0005515	protein binding	PMID:17728244^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9DUN1	F
	GO:0005515	protein binding	PMID:20195357^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q15059	F
	GO:0005515	protein binding	PMID:20195357^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q86XR8	F
	GO:0005515	protein binding	PMID:20551172^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TEL6	F
	GO:0005515	protein binding	PMID:20691906^[15]	IPI: Inferred from Physical Interaction	UniProtKB:Q2T9S0	F
	GO:0005515	protein binding	PMID:9308237^[16]	IPI: Inferred from Physical Interaction	UniProtKB:Q13105	F
	GO:0005515	protein binding	PMID:9708738^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4A5	F
	GO:0005515	protein binding	PMID:9708738^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4A5	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002418	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003327	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012682	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	PMID:11793365^[18]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:15994933^[19]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:9187264^[20]	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0190	C
	GO:0005654	nucleoplasm	PMID:17558397^[21]	IDA: Inferred from Direct Assay		C
	GO:0005730	nucleolus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0188	C
	GO:0005730	nucleolus	PMID:17558397^[21]	IDA: Inferred from Direct Assay		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:9924025^[2]	TAS: Traceable Author Statement		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001092	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002418	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003327	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011598	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012682	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006357	regulation of transcription from RNA polymerase II promoter	PMID:9924025^[2]	TAS: Traceable Author Statement		P
	GO:0006879	cellular iron ion homeostasis	PMID:9924025^[2]	TAS: Traceable Author Statement		P
	GO:0007050	cell cycle arrest	PMID:10962037^[22]	TAS: Traceable Author Statement		P
	GO:0008283	cell proliferation	PMID:10962037^[22]	TAS: Traceable Author Statement		P
	GO:0008284	positive regulation of cell proliferation	PMID:15994933^[19]	IDA: Inferred from Direct Assay		P
	GO:0032204	regulation of telomere maintenance	PMID:17765874^[24]	IMP: Inferred from Mutant Phenotype		P
	GO:0042493	response to drug	PMID:18291362^[25]	IEP: Inferred from Expression Pattern		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:17558397^[21]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:18818310^[23]	IDA: Inferred from Direct Assay		P
	GO:0070888	E-box binding	PMID:18818310^[23]	IDA: Inferred from Direct Assay		F
	GO:0090096	positive regulation of metanephric cap mesenchymal cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01108	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Bannasch D et al. (1999) Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN. Oncogene 18: 6810-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Wu KJ et al. (1999) Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science 283: 676-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Berg T et al. (2002) Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts. Proc Natl Acad Sci U S A 99: 3830-5 PubMed GONUTS page
↑ ^4.0 ^4.1 Mädge B et al. (2003) Yaf2 inhibits Myc biological function. Cancer Lett 193: 171-6 PubMed GONUTS page
↑ ^5.0 ^5.1 Yada M et al. (2004) Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 23: 2116-25 PubMed GONUTS page
↑ ^6.0 ^6.1 Patel JH & McMahon SB (2006) Targeting of Miz-1 is essential for Myc-mediated apoptosis. J Biol Chem 281: 3283-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Fujii M et al. (2006) SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes. Mol Cell 24: 771-83 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Koch HB et al. (2007) Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Cell Cycle 6: 205-17 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 ^9.14 ^9.15 ^9.16 ^9.17 ^9.18 ^9.19 ^9.20 ^9.21 ^9.22 ^9.23 ^9.24 ^9.25 ^9.26 ^9.27 ^9.28 ^9.29 ^9.30 ^9.31 ^9.32 ^9.33 ^9.34 ^9.35 ^9.36 ^9.37 ^9.38 ^9.39 ^9.40 ^9.41 ^9.42 ^9.43 ^9.44 ^9.45 ^9.46 ^9.47 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Gordan JD et al. (2007) HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 11: 335-47 PubMed GONUTS page
↑ ^11.0 ^11.1 Junttila MR et al. (2007) CIP2A inhibits PP2A in human malignancies. Cell 130: 51-62 PubMed GONUTS page
↑ ^12.0 ^12.1 Lubyova B et al. (2007) Stimulation of c-Myc transcriptional activity by vIRF-3 of Kaposi sarcoma-associated herpesvirus. J Biol Chem 282: 31944-53 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Miyamoto-Sato E et al. (2010) A comprehensive resource of interacting protein regions for refining human transcription factor networks. PLoS One 5: e9289 PubMed GONUTS page
↑ ^14.0 ^14.1 Choi SH et al. (2010) Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells. Genes Dev 24: 1236-41 PubMed GONUTS page
↑ ^15.0 ^15.1 Conacci-Sorrell M et al. (2010) Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Cell 142: 480-93 PubMed GONUTS page
↑ ^16.0 ^16.1 Schneider A et al. (1997) Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc. Curr Top Microbiol Immunol 224: 137-46 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 McMahon SB et al. (1998) The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94: 363-74 PubMed GONUTS page
↑ ^18.0 ^18.1 Wong SC et al. (2002) Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J Pathol 196: 145-53 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Huang A et al. (2005) Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res 65: 5607-19 PubMed GONUTS page
↑ ^20.0 ^20.1 Shayo C et al. (1997) Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937. Mol Pharmacol 51: 983-90 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 Popov N et al. (2007) The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol 9: 765-74 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 Felsher DW et al. (2000) Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. Proc Natl Acad Sci U S A 97: 10544-8 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 Jung P et al. (2008) AP4 encodes a c-MYC-inducible repressor of p21. Proc Natl Acad Sci U S A 105: 15046-51 PubMed GONUTS page
↑ ^24.0 ^24.1 Kim H & Chen J (2007) c-Myc interacts with TRF1/PIN2 and regulates telomere length. Biochem Biophys Res Commun 362: 842-7 PubMed GONUTS page
↑ ^25.0 ^25.1 Han A et al. (2008) Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol 583: 26-31 PubMed GONUTS page

[PMID:10597290-0] 1.0 ^1.1 ^1.2 ^1.3 Bannasch D et al. (1999) Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN. Oncogene 18: 6810-7 PubMed GONUTS page

[PMID:9924025-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Wu KJ et al. (1999) Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science 283: 676-9 PubMed GONUTS page

[PMID:11891322-2] 3.0 ^3.1 Berg T et al. (2002) Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts. Proc Natl Acad Sci U S A 99: 3830-5 PubMed GONUTS page

[PMID:12706874-3] 4.0 ^4.1 Mädge B et al. (2003) Yaf2 inhibits Myc biological function. Cancer Lett 193: 171-6 PubMed GONUTS page

[PMID:15103331-4] 5.0 ^5.1 Yada M et al. (2004) Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 23: 2116-25 PubMed GONUTS page

[PMID:16352593-5] 6.0 ^6.1 Patel JH & McMahon SB (2006) Targeting of Miz-1 is essential for Myc-mediated apoptosis. J Biol Chem 281: 3283-9 PubMed GONUTS page

[PMID:17157259-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Fujii M et al. (2006) SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes. Mol Cell 24: 771-83 PubMed GONUTS page

[PMID:17314511-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Koch HB et al. (2007) Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. Cell Cycle 6: 205-17 PubMed GONUTS page

[PMID:17353931-8] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 ^9.14 ^9.15 ^9.16 ^9.17 ^9.18 ^9.19 ^9.20 ^9.21 ^9.22 ^9.23 ^9.24 ^9.25 ^9.26 ^9.27 ^9.28 ^9.29 ^9.30 ^9.31 ^9.32 ^9.33 ^9.34 ^9.35 ^9.36 ^9.37 ^9.38 ^9.39 ^9.40 ^9.41 ^9.42 ^9.43 ^9.44 ^9.45 ^9.46 ^9.47 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page

[PMID:17418410-9] 10.0 ^10.1 ^10.2 ^10.3 Gordan JD et al. (2007) HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 11: 335-47 PubMed GONUTS page

[PMID:17632056-10] 11.0 ^11.1 Junttila MR et al. (2007) CIP2A inhibits PP2A in human malignancies. Cell 130: 51-62 PubMed GONUTS page

[PMID:17728244-11] 12.0 ^12.1 Lubyova B et al. (2007) Stimulation of c-Myc transcriptional activity by vIRF-3 of Kaposi sarcoma-associated herpesvirus. J Biol Chem 282: 31944-53 PubMed GONUTS page

[PMID:20195357-12] 13.0 ^13.1 ^13.2 ^13.3 Miyamoto-Sato E et al. (2010) A comprehensive resource of interacting protein regions for refining human transcription factor networks. PLoS One 5: e9289 PubMed GONUTS page

[PMID:20551172-13] 14.0 ^14.1 Choi SH et al. (2010) Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells. Genes Dev 24: 1236-41 PubMed GONUTS page

[PMID:20691906-14] 15.0 ^15.1 Conacci-Sorrell M et al. (2010) Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Cell 142: 480-93 PubMed GONUTS page

[PMID:9308237-15] 16.0 ^16.1 Schneider A et al. (1997) Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc. Curr Top Microbiol Immunol 224: 137-46 PubMed GONUTS page

[PMID:9708738-16] 17.0 ^17.1 ^17.2 ^17.3 McMahon SB et al. (1998) The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94: 363-74 PubMed GONUTS page

[PMID:11793365-17] 18.0 ^18.1 Wong SC et al. (2002) Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J Pathol 196: 145-53 PubMed GONUTS page

[PMID:15994933-18] 19.0 ^19.1 ^19.2 ^19.3 Huang A et al. (2005) Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res 65: 5607-19 PubMed GONUTS page

[PMID:9187264-19] 20.0 ^20.1 Shayo C et al. (1997) Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937. Mol Pharmacol 51: 983-90 PubMed GONUTS page

[PMID:17558397-20] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 Popov N et al. (2007) The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol 9: 765-74 PubMed GONUTS page

[PMID:10962037-21] 22.0 ^22.1 ^22.2 ^22.3 Felsher DW et al. (2000) Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. Proc Natl Acad Sci U S A 97: 10544-8 PubMed GONUTS page

[PMID:18818310-22] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 Jung P et al. (2008) AP4 encodes a c-MYC-inducible repressor of p21. Proc Natl Acad Sci U S A 105: 15046-51 PubMed GONUTS page

[PMID:17765874-23] 24.0 ^24.1 Kim H & Chen J (2007) c-Myc interacts with TRF1/PIN2 and regulates telomere length. Biochem Biophys Res Commun 362: 842-7 PubMed GONUTS page

[PMID:18291362-24] 25.0 ^25.1 Han A et al. (2008) Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol 583: 26-31 PubMed GONUTS page

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