HUMAN:MTRR

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	MTRR
Protein Name(s)	Methionine synthase reductase MSR
External Links
UniProt Identifier	MTRR_HUMAN
UniProt Accessions	Q9UBK8, O60471, Q32MA9, Q7Z4M8,
EMBL	AF121213, AF121202, AF121203, AF121204, AF121205, AF121206, AF121207, AF121208, AF121209, AF121210, AF121211, AF121212, AF121214, AF121213, AF121202, AF121203, AF121204, AF121205, AF121206, AF121207, AF121208, AF121209, AF121210, AF121211, AF121212, AF025794, AC010346, AC025174, BC054816, BC109216,
RefSeq	NP_002445.2, NP_076915.2,
PDB	2QTL, 2QTZ,
Ensembl	ENST00000264668,
Pfam	PF00667, PF00258, PF00175,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0005506	iron ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001094	F
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005829	cytosol	PMID:9501215^[1]	TAS: Traceable Author Statement		C
	GO:0006555	methionine metabolic process	PMID:9501215^[1]	TAS: Traceable Author Statement		P
	GO:0008652	cellular amino acid biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0028	P
	GO:0009086	methionine biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0486	P
	GO:0010181	FMN binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001094	F
	GO:0010181	FMN binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008254	F
	GO:0010181	FMN binding	PMID:9501215^[1]	TAS: Traceable Author Statement		F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001433	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001709	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003097	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008254	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017927	F
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F
	GO:0030586	(methionine synthase) reductase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.16.1.8	F
	GO:0030586	(methionine synthase) reductase activity	PMID:9501215^[1]	TAS: Traceable Author Statement		F
	GO:0050660	flavin adenine dinucleotide binding	PMID:9501215^[1]	TAS: Traceable Author Statement		F
	GO:0050661	NADP binding	PMID:9501215^[1]	TAS: Traceable Author Statement		F
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001094	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001433	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001709	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003097	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017927	P
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P
	GO:0055114	oxidation-reduction process	PMID:9501215^[1]	TAS: Traceable Author Statement		P
	GO:0005506	iron ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001094	F
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005829	cytosol	PMID:9501215^[1]	TAS: Traceable Author Statement		C
	GO:0006555	methionine metabolic process	PMID:9501215^[1]	TAS: Traceable Author Statement		P
	GO:0008652	cellular amino acid biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0028	P
	GO:0009086	methionine biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0486	P
	GO:0010181	FMN binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001094	F
	GO:0010181	FMN binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008254	F
	GO:0010181	FMN binding	PMID:9501215^[1]	TAS: Traceable Author Statement		F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001433	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001709	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003097	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008254	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017927	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017938	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR023173	F
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F
	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor	PMID:17892308^[2]	IDA: Inferred from Direct Assay		F
	GO:0030586	(methionine synthase) reductase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.16.1.8	F
	GO:0030586	(methionine synthase) reductase activity	PMID:17892308^[2]	TAS: Traceable Author Statement		F
	GO:0030586	(methionine synthase) reductase activity	PMID:9501215^[1]	TAS: Traceable Author Statement		F
	GO:0050660	flavin adenine dinucleotide binding	PMID:17892308^[2]	IDA: Inferred from Direct Assay		F
	GO:0050660	flavin adenine dinucleotide binding	PMID:9501215^[1]	TAS: Traceable Author Statement		F
	GO:0050661	NADP binding	PMID:9501215^[1]	TAS: Traceable Author Statement		F
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001094	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001433	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001709	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003097	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017927	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017938	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR023173	P
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P
	GO:0055114	oxidation-reduction process	PMID:9501215^[1]	TAS: Traceable Author Statement		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Leclerc D et al. (1998) Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc Natl Acad Sci U S A 95: 3059-64 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Wolthers KR et al. (2007) Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry. Biochemistry 46: 11833-44 PubMed GONUTS page

[PMID:9501215-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Leclerc D et al. (1998) Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc Natl Acad Sci U S A 95: 3059-64 PubMed GONUTS page

[PMID:17892308-1] 2.0 ^2.1 ^2.2 Wolthers KR et al. (2007) Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry. Biochemistry 46: 11833-44 PubMed GONUTS page

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HUMAN:MTRR

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