HUMAN:MRE11

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	MRE11A (synonyms: HNGS1, MRE11)
Protein Name(s)	Double-strand break repair protein MRE11A Meiotic recombination 11 homolog 1 MRE11 homolog 1 Meiotic recombination 11 homolog A MRE11 homolog A
External Links
EMBL	U37359 AF022778 AF073362 AF303395 AF303379 AF303380 AF303381 AF303382 AF303383 AF303384 AF303385 AF303386 AF303387 AF303388 AF303389 AF303390 AF303391 AF303392 AF303393 AF303394 AY584241 BC063458
IPI	IPI00218853 IPI00940798
RefSeq	NP_005581.2 NP_005582.1
UniGene	Hs.192649
ProteinModelPortal	P49959
DIP	DIP-33238N
IntAct	P49959
MINT	MINT-131851
STRING	P49959
PhosphoSite	P49959
PRIDE	P49959
Ensembl	ENST00000323929
GeneID	4361
KEGG	hsa:4361
UCSC	uc001peu.1 uc001pev.1
CTD	4361
GeneCards	GC11M090216
H-InvDB	HIX0010030
HGNC	HGNC:7230
HPA	CAB004081 HPA002691
MIM	600814 604391
neXtProt	NX_P49959
Orphanet	251347
PharmGKB	PA30934
eggNOG	prNOG16423
HOVERGEN	HBG052508
InParanoid	P49959
PhylomeDB	P49959
Pathway_Interaction_DB	bard1pathway telomerasepathway
Reactome	REACT_216 REACT_27271
NextBio	17163
PMAP-CutDB	P49959
ArrayExpress	P49959
Bgee	P49959
CleanEx	HS_MRE11A
Genevestigator	P49959
GermOnline	ENSG00000020922
GO	GO:0030870 GO:0005654 GO:0008408 GO:0003690 GO:0030145 GO:0008022 GO:0000014 GO:0032508 GO:0000724 GO:0006303 GO:0032876 GO:0033674 GO:0031954 GO:0007131 GO:0000019 GO:0007062 GO:0007004
InterPro	IPR003701 IPR004843 IPR007281
PANTHER	PTHR10139
Pfam	PF00149 PF04152
PIRSF	PIRSF000882
TIGRFAMs	TIGR00583

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity	PMID:9705271^[1]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0000019	regulation of mitotic recombination	PMID:8530104^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0000075	cell cycle checkpoint	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034405	P	Seeded From UniProt
	GO:0000724	double-strand break repair via homologous recombination	Reactome:REACT_1874	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0000790	nuclear chromatin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000012940	C	Seeded From UniProt
	GO:0000794	condensed nuclear chromosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000012940	C	Seeded From UniProt
	GO:0003690	double-stranded DNA binding	PMID:10802669^[3]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0004518	nuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0540	F	Seeded From UniProt
	GO:0004518	nuclease activity	PMID:15790808^[4]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0004519	endonuclease activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007281	F	Seeded From UniProt
	GO:0004519	endonuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0255	F	Seeded From UniProt
	GO:0004520	endodeoxyribonuclease activity	PMID:9651580^[5]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0004527	exonuclease activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003701	F	Seeded From UniProt
	GO:0004527	exonuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0269	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18716619^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q99708	F	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007281	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034405	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000012940	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C	Seeded From UniProt
	GO:0005634	nucleus	PMID:10802669^[3]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:18029348^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005654	nucleoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000012940	C	Seeded From UniProt
	GO:0005654	nucleoplasm	PMID:9651580^[5]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_1232	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_516	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_730	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0006259	DNA metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003701	P	Seeded From UniProt
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P	Seeded From UniProt
	GO:0006281	DNA repair	PMID:9705271^[1]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006281	DNA repair	PMID:9931460^[8]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006281	DNA repair	Reactome:REACT_216	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006302	double-strand break repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007281	P	Seeded From UniProt
	GO:0006302	double-strand break repair	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034405	P	Seeded From UniProt
	GO:0006302	double-strand break repair	PMID:10612394^[9]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006302	double-strand break repair	Reactome:REACT_2054	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:9651580^[5]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006310	DNA recombination	PMID:9705271^[1]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034405	P	Seeded From UniProt
	GO:0007004	telomere maintenance via telomerase	PMID:9705271^[1]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007004	telomere maintenance via telomerase	PMID:9931460^[8]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007062	sister chromatid cohesion	PMID:15917200^[10]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007126	meiosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0469	P	Seeded From UniProt
	GO:0007129	synapsis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034405	P	Seeded From UniProt
	GO:0007131	reciprocal meiotic recombination	PMID:8530104^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007131	reciprocal meiotic recombination	PMID:9931460^[8]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007507	heart development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000012940	P	Seeded From UniProt
	GO:0008022	protein C-terminus binding	PMID:9590181^[11]	IPI: Inferred from Physical Interaction	UniProtKB:O60934	F	Seeded From UniProt
	GO:0008283	cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034405	P	Seeded From UniProt
	GO:0008408	3'-5' exonuclease activity	PMID:9651580^[5]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0016787	hydrolase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004843	F	Seeded From UniProt
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	Seeded From UniProt
	GO:0030145	manganese ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007281	F	Seeded From UniProt
	GO:0030870	Mre11 complex	PMID:15790808^[4]	NAS: Non-traceable Author Statement		C	Seeded From UniProt
	GO:0030870	Mre11 complex	PMID:19151086^[12]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0031954	positive regulation of protein autophosphorylation	PMID:15790808^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0032508	DNA duplex unwinding	PMID:15790808^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0032876	negative regulation of DNA endoreduplication	PMID:15917200^[10]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0033674	positive regulation of kinase activity	PMID:15790808^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000012940	C	Seeded From UniProt
	GO:0051276	chromosome organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034405	P	Seeded From UniProt
	GO:0005730	nucleolus	PMID:18029348^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0000781	chromosome, telomeric region	PMID:15149599^[13]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0003677	DNA binding	PMID:15790808^[4]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0004003	ATP-dependent DNA helicase activity	PMID:15790808^[4]	IMP: Inferred from Mutant Phenotype		F	Seeded From UniProt
	GO:0008408	3'-5' exonuclease activity	PMID:9651580^[5]	IDA: Inferred from Direct Assay		F	Figure 2	complete
	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:9651580^[5]	IDA: Inferred from Direct Assay		P	Figure 5	complete
	GO:0004520	endodeoxyribonuclease activity	PMID:9705271^[1]	IDA: Inferred from Direct Assay		F	Figure 2	complete
	GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity	PMID:9705271^[1]	IDA: Inferred from Direct Assay		F	Figures 3,4,5	complete
	GO:0008408	3'-5' exonuclease activity	PMID:9705271^[1]	IDA: Inferred from Direct Assay		F	Figure 5	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Trujillo KM et al. (1998) Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J Biol Chem 273: 21447-50 PubMed GONUTS page
↑ ^2.0 ^2.1 Petrini JH et al. (1995) Isolation and characterization of the human MRE11 homologue. Genomics 29: 80-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Gatei M et al. (2000) ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet 25: 115-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Lee JH & Paull TT (2005) ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308: 551-4 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Paull TT & Gellert M (1998) The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol Cell 1: 969-79 PubMed GONUTS page
↑ Huertas P et al. (2008) CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455: 689-92 PubMed GONUTS page
↑ ^7.0 ^7.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Chamankhah M et al. (1998) Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions. Gene 225: 107-16 PubMed GONUTS page
↑ Stewart GS et al. (1999) The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 99: 577-87 PubMed GONUTS page
↑ ^10.0 ^10.1 Strachan T (2005) Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation. Curr Opin Genet Dev 15: 258-64 PubMed GONUTS page
↑ Carney JP et al. (1998) The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93: 477-86 PubMed GONUTS page
↑ van der Linden E et al. (2009) RAD50 and NBS1 form a stable complex functional in DNA binding and tethering. Nucleic Acids Res 37: 1580-8 PubMed GONUTS page
↑ Herbig U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14: 501-13 PubMed GONUTS page

[PMID:9705271-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Trujillo KM et al. (1998) Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J Biol Chem 273: 21447-50 PubMed GONUTS page

[PMID:8530104-1] 2.0 ^2.1 Petrini JH et al. (1995) Isolation and characterization of the human MRE11 homologue. Genomics 29: 80-6 PubMed GONUTS page

[PMID:10802669-2] 3.0 ^3.1 Gatei M et al. (2000) ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet 25: 115-9 PubMed GONUTS page

[PMID:15790808-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Lee JH & Paull TT (2005) ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308: 551-4 PubMed GONUTS page

[PMID:9651580-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Paull TT & Gellert M (1998) The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol Cell 1: 969-79 PubMed GONUTS page

[PMID:18716619-5] Huertas P et al. (2008) CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455: 689-92 PubMed GONUTS page

[PMID:18029348-6] 7.0 ^7.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:9931460-7] 8.0 ^8.1 ^8.2 Chamankhah M et al. (1998) Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions. Gene 225: 107-16 PubMed GONUTS page

[PMID:10612394-8] Stewart GS et al. (1999) The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 99: 577-87 PubMed GONUTS page

[PMID:15917200-9] 10.0 ^10.1 Strachan T (2005) Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation. Curr Opin Genet Dev 15: 258-64 PubMed GONUTS page

[PMID:9590181-10] Carney JP et al. (1998) The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93: 477-86 PubMed GONUTS page

[PMID:19151086-11] van der Linden E et al. (2009) RAD50 and NBS1 form a stable complex functional in DNA binding and tethering. Nucleic Acids Res 37: 1580-8 PubMed GONUTS page

[PMID:15149599-12] Herbig U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14: 501-13 PubMed GONUTS page

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HUMAN:MRE11

Contents

Annotations

Notes

References

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