HUMAN:MK14

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	MAPK14 ( synonyms: CSBP, CSBP1, CSBP2, CSPB1, MXI2 )
Protein Name(s)	Mitogen-activated protein kinase 14 MAP kinase 14 MAPK 14 Cytokine suppressive anti-inflammatory drug-binding protein CSAID-binding protein CSBP MAP kinase MXI2 MAX-interacting protein 2 Mitogen-activated protein kinase p38 alpha MAP kinase p38 alpha SAPK2A
External Links
UniProt Identifier	MK14_HUMAN
UniProt Accessions	Q16539, A6ZJ92, A8K6P4, B0LPH0, O60776, Q13083, Q14084, Q8TDX0,
EMBL	L35263, L35264, L35253, U19775, AF100544, AB074150, AK291709, BT006933, CR536505, EU332860, Z95152, CH471081, BC000092, BC031574,
PIR	S53536,
RefSeq	NP_001306.1, NP_620581.1, NP_620582.1, NP_620583.1,
PDB	1A9U, 1BL6, 1BL7, 1BMK, 1DI9, 1IAN, 1KV1, 1KV2, 1M7Q, 1OUK, 1OUY, 1OVE, 1OZ1, 1R39, 1R3C, 1W7H, 1W82, 1W83, 1W84, 1WBN, 1WBO, 1WBS, 1WBT, 1WBV, 1WBW, 1WFC, 1YQJ, 1ZYJ, 1ZZ2, 1ZZL, 2BAJ, 2BAK, 2BAL, 2BAQ, 2FSL, 2FSM, 2FSO, 2FST, 2GFS, 2I0H, 2NPQ, 2OKR, 2ONL, 2QD9, 2RG5, 2RG6, 2ZAZ, 2ZB0, 2ZB1, 3BV2, 3BV3, 3BX5, 3C5U, 3CTQ, 3D7Z, 3D83, 3DS6, 3DT1, 3E92, 3E93, 3FC1, 3FI4, 3FKL, 3FKN, 3FKO, 3FL4, 3FLN, 3FLQ, 3FLS, 3FLW, 3FLY, 3FLZ, 3FMH, 3FMJ, 3FMK, 3FML, 3FMM, 3FMN, 3FSF, 3FSK, 3GC7, 3GCP, 3GCQ, 3GCS, 3GCU, 3GCV, 3GFE, 3GI3, 3HA8, 3HEC, 3HEG, 3HL7, 3HLL, 3HP2, 3HP5, 3HRB, 3HUB, 3HUC, 3HV3, 3HV4, 3HV5, 3HV6, 3HV7, 3HVC, 3IPH, 3ITZ, 3IW5, 3IW6, 3IW7, 3IW8, 3K3I, 3K3J, 3KF7, 3KQ7, 3L8S, 3L8X, 3LFA, 3LFB, 3LFC, 3LFD, 3LFE, 3LFF, 3LHJ, 3MGY, 3MH0, 3MH1, 3MH2, 3MH3, 3MPA, 3MPT, 3MVL, 3MVM, 3MW1, 3NEW, 3NNU, 3NNV, 3NNW, 3NNX, 3NWW, 3O8P, 3O8T, 3O8U, 3OBG, 3OBJ, 3OC1, 3OCG, 3OD6, 3ODY, 3ODZ, 3OEF,
IntAct	Q16539,
Ensembl	ENST00000229794,
Pfam	PF00069,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding		IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0000187	activation of MAPK activity	Reactome:REACT_21399	TAS: Traceable Author Statement		P
	GO:0002224	toll-like receptor signaling pathway	Reactome:REACT_8006	TAS: Traceable Author Statement		P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	PMID:15276183^[1]	EXP: Inferred from Experiment		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	PMID:15276183^[1]	EXP: Inferred from Experiment		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6782	TAS: Traceable Author Statement		P
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004674	protein serine/threonine kinase activity	PMID:10878576^[2]	EXP: Inferred from Experiment		F
	GO:0004674	protein serine/threonine kinase activity	PMID:8910365^[3]	EXP: Inferred from Experiment		F
	GO:0004674	protein serine/threonine kinase activity	PMID:9687510^[4]	EXP: Inferred from Experiment		F
	GO:0004674	protein serine/threonine kinase activity		IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0004674	protein serine/threonine kinase activity	Reactome:REACT_21276	TAS: Traceable Author Statement		F
	GO:0004707	MAP kinase activity	PMID:7997261^[5]	IDA: Inferred from Direct Assay		F
	GO:0004707	MAP kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003527	F
	GO:0004707	MAP kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008352	F
	GO:0004707	MAP kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.11.24	F
	GO:0004708	MAP kinase kinase activity	PMID:10706854^[6]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:12761180^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q16512	F
	GO:0005515	protein binding	PMID:16189514^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q07352	F
	GO:0005515	protein binding	PMID:16636664^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P09211	F
	GO:0005515	protein binding	PMID:16751104^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NEM7	F
	GO:0005515	protein binding	PMID:17255097^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P49137	F
	GO:0005515	protein binding	PMID:19776015^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UIG0	F
	GO:0005515	protein binding	PMID:20368287^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q92574	F
	GO:0005515	protein binding	PMID:9792677^[14]	IPI: Inferred from Physical Interaction	UniProtKB:O75676	F
	GO:0005524	ATP binding		IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003527	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008352	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005634	nucleus		IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P47811	C
	GO:0005654	nucleoplasm	PMID:10878576^[2]	EXP: Inferred from Experiment		C
	GO:0005654	nucleoplasm	PMID:9687510^[4]	EXP: Inferred from Experiment		C
	GO:0005654	nucleoplasm	Reactome:REACT_21276	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_21358	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_21375	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_21395	TAS: Traceable Author Statement		C
	GO:0005737	cytoplasm		IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P47811	C
	GO:0005829	cytosol	PMID:8846784^[15]	EXP: Inferred from Experiment		C
	GO:0005829	cytosol	PMID:8910365^[3]	EXP: Inferred from Experiment		C
	GO:0005829	cytosol	Reactome:REACT_21358	TAS: Traceable Author Statement		C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003527	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008352	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0006928	cellular component movement	PMID:10912793^[16]	TAS: Traceable Author Statement		P
	GO:0006935	chemotaxis	PMID:10706854^[6]	TAS: Traceable Author Statement		P
	GO:0006950	response to stress	PMID:7997261^[5]	IDA: Inferred from Direct Assay		P
	GO:0007165	signal transduction	PMID:10706854^[6]	TAS: Traceable Author Statement		P
	GO:0007166	cell surface receptor linked signaling pathway	PMID:10706854^[6]	TAS: Traceable Author Statement		P
	GO:0007243	intracellular protein kinase cascade	PMID:10838079^[17]	IDA: Inferred from Direct Assay		P
	GO:0007265	Ras protein signal transduction	PMID:11520933^[18]	EXP: Inferred from Experiment		P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0008063	Toll signaling pathway	Reactome:REACT_6894	TAS: Traceable Author Statement		P
	GO:0010670	positive regulation of oxygen and reactive oxygen species metabolic process	PMID:20160708^[19]	IMP: Inferred from Mutant Phenotype		P
	GO:0016070	RNA metabolic process	Reactome:REACT_21257	TAS: Traceable Author Statement		P
	GO:0016071	mRNA metabolic process	Reactome:REACT_20605	TAS: Traceable Author Statement		P
	GO:0016301	kinase activity		IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016740	transferase activity		IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0030168	platelet activation	Reactome:REACT_798	TAS: Traceable Author Statement		P
	GO:0034130	toll-like receptor 1 signaling pathway	Reactome:REACT_8005	TAS: Traceable Author Statement		P
	GO:0034134	toll-like receptor 2 signaling pathway	Reactome:REACT_7980	TAS: Traceable Author Statement		P
	GO:0034138	toll-like receptor 3 signaling pathway	Reactome:REACT_6783	TAS: Traceable Author Statement		P
	GO:0034142	toll-like receptor 4 signaling pathway	Reactome:REACT_6890	TAS: Traceable Author Statement		P
	GO:0042692	muscle cell differentiation	Reactome:REACT_21303	TAS: Traceable Author Statement		P
	GO:0042770	signal transduction in response to DNA damage	PMID:20160708^[19]	IMP: Inferred from Mutant Phenotype		P
	GO:0045087	innate immune response	Reactome:REACT_6802	TAS: Traceable Author Statement		P
	GO:0048011	nerve growth factor receptor signaling pathway	Reactome:REACT_11061	TAS: Traceable Author Statement		P
	GO:0051090	regulation of transcription factor activity	Reactome:REACT_21326	TAS: Traceable Author Statement		P
	GO:0051149	positive regulation of muscle cell differentiation	PMID:15923648^[20]	EXP: Inferred from Experiment		P
	GO:0051403	stress-activated MAPK cascade	Reactome:REACT_21308	TAS: Traceable Author Statement		P
	GO:0071479	cellular response to ionizing radiation	PMID:20160708^[19]	IMP: Inferred from Mutant Phenotype		P
	GO:0090400	stress-induced premature senescence	PMID:20160708^[19]	IMP: Inferred from Mutant Phenotype		P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0000187	activation of MAPK activity	Reactome:REACT_21399	TAS: Traceable Author Statement		P
	GO:0002224	toll-like receptor signaling pathway	Reactome:REACT_8006	TAS: Traceable Author Statement		P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_27215	TAS: Traceable Author Statement		P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_6788	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6782	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809	TAS: Traceable Author Statement		P
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0004674	protein serine/threonine kinase activity	Reactome:REACT_12032	TAS: Traceable Author Statement		F
	GO:0004674	protein serine/threonine kinase activity	Reactome:REACT_21375	TAS: Traceable Author Statement		F
	GO:0004707	MAP kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003527	F
	GO:0004707	MAP kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008352	F
	GO:0004707	MAP kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.11.24	F
	GO:0004707	MAP kinase activity	PMID:7997261^[5]	IDA: Inferred from Direct Assay		F
	GO:0004708	MAP kinase kinase activity	PMID:10706854^[6]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:12761180^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q16512	F
	GO:0005515	protein binding	PMID:16189514^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q07352	F
	GO:0005515	protein binding	PMID:16636664^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P09211	F
	GO:0005515	protein binding	PMID:16751104^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NEM7	F
	GO:0005515	protein binding	PMID:17255097^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P49137	F
	GO:0005515	protein binding	PMID:19776015^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UIG0	F
	GO:0005515	protein binding	PMID:20368287^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q92574	F
	GO:0005515	protein binding	PMID:9792677^[14]	IPI: Inferred from Physical Interaction	UniProtKB:O75676	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003527	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008352	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P47811	C
	GO:0005654	nucleoplasm	Reactome:REACT_12546	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_21276	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_21288	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_21358	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_21375	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_21395	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_6719	TAS: Traceable Author Statement		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P47811	C
	GO:0005829	cytosol	Reactome:REACT_12016	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12032	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_20541	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_20632	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_21288	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_21358	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_23951	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25129	TAS: Traceable Author Statement		C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003527	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008352	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0006928	cellular component movement	PMID:10912793^[16]	TAS: Traceable Author Statement		P
	GO:0006935	chemotaxis	PMID:10706854^[6]	TAS: Traceable Author Statement		P
	GO:0006950	response to stress	PMID:7997261^[5]	IDA: Inferred from Direct Assay		P
	GO:0007165	signal transduction	PMID:10706854^[6]	TAS: Traceable Author Statement		P
	GO:0007166	cell surface receptor linked signaling pathway	PMID:10706854^[6]	TAS: Traceable Author Statement		P
	GO:0007243	intracellular protein kinase cascade	PMID:10838079^[17]	IDA: Inferred from Direct Assay		P
	GO:0007265	Ras protein signal transduction	Reactome:REACT_12033	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0008063	Toll signaling pathway	Reactome:REACT_6894	TAS: Traceable Author Statement		P
	GO:0016070	RNA metabolic process	Reactome:REACT_21257	TAS: Traceable Author Statement		P
	GO:0016071	mRNA metabolic process	Reactome:REACT_20605	TAS: Traceable Author Statement		P
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0030168	platelet activation	Reactome:REACT_798	TAS: Traceable Author Statement		P
	GO:0034130	toll-like receptor 1 signaling pathway	Reactome:REACT_8005	TAS: Traceable Author Statement		P
	GO:0034134	toll-like receptor 2 signaling pathway	Reactome:REACT_7980	TAS: Traceable Author Statement		P
	GO:0034138	toll-like receptor 3 signaling pathway	Reactome:REACT_6783	TAS: Traceable Author Statement		P
	GO:0034142	toll-like receptor 4 signaling pathway	Reactome:REACT_6890	TAS: Traceable Author Statement		P
	GO:0042692	muscle cell differentiation	Reactome:REACT_21303	TAS: Traceable Author Statement		P
	GO:0042770	signal transduction in response to DNA damage	PMID:20160708^[19]	IMP: Inferred from Mutant Phenotype		P
	GO:0045087	innate immune response	Reactome:REACT_6802	TAS: Traceable Author Statement		P
	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:18440775^[21]	IMP: Inferred from Mutant Phenotype		P
	GO:0048011	nerve growth factor receptor signaling pathway	Reactome:REACT_11061	TAS: Traceable Author Statement		P
	GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	Reactome:REACT_21326	TAS: Traceable Author Statement		P
	GO:0051149	positive regulation of muscle cell differentiation	Reactome:REACT_21402	TAS: Traceable Author Statement		P
	GO:0051403	stress-activated MAPK cascade	Reactome:REACT_21308	TAS: Traceable Author Statement		P
	GO:0071363	cellular response to growth factor stimulus	PMID:18440775^[21]	IMP: Inferred from Mutant Phenotype		P
	GO:0071479	cellular response to ionizing radiation	PMID:20160708^[19]	IMP: Inferred from Mutant Phenotype		P
	GO:0090400	stress-induced premature senescence	PMID:20160708^[19]	IMP: Inferred from Mutant Phenotype		P
	GO:2000379	positive regulation of reactive oxygen species metabolic process	PMID:20160708^[19]	IMP: Inferred from Mutant Phenotype		P
	GO:0051247	positive regulation of protein metabolic process	PMID:22027397^[22]	IMP: Inferred from Mutant Phenotype		P	Fig. 5A	complete
	GO:0031281	positive regulation of cyclase activity	PMID:22027397^[22]	IMP: Inferred from Mutant Phenotype		P	Fig. 5D	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Gangloff M & Gay NJ (2004) MD-2: the Toll 'gatekeeper' in endotoxin signalling. Trends Biochem Sci 29: 294-300 PubMed GONUTS page
↑ ^2.0 ^2.1 Martín-Blanco E (2000) p38 MAPK signalling cascades: ancient roles and new functions. Bioessays 22: 637-45 PubMed GONUTS page
↑ ^3.0 ^3.1 Kramer RM et al. (1996) p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2. J Biol Chem 271: 27723-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Deak M et al. (1998) Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J 17: 4426-41 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Lee JC et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372: 739-46 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Kampen GT et al. (2000) Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 95: 1911-7 PubMed GONUTS page
↑ ^7.0 ^7.1 Takahashi M et al. (2003) Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. J Biochem 133: 181-7 PubMed GONUTS page
↑ ^8.0 ^8.1 Rual JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437: 1173-8 PubMed GONUTS page
↑ ^9.0 ^9.1 Wu Y et al. (2006) Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals. Oncogene 25: 5787-800 PubMed GONUTS page
↑ ^10.0 ^10.1 Zohn IE et al. (2006) p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell 125: 957-69 PubMed GONUTS page
↑ ^11.0 ^11.1 ter Haar E et al. (2007) Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. J Biol Chem 282: 9733-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Oya H et al. (2009) Phosphorylation of Williams syndrome transcription factor by MAPK induces a switching between two distinct chromatin remodeling complexes. J Biol Chem 284: 32472-82 PubMed GONUTS page
↑ ^13.0 ^13.1 Pilot-Storck F et al. (2010) Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Mol Cell Proteomics 9: 1578-93 PubMed GONUTS page
↑ ^14.0 ^14.1 Pierrat B et al. (1998) RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). J Biol Chem 273: 29661-71 PubMed GONUTS page
↑ Ben-Levy R et al. (1995) Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. EMBO J 14: 5920-30 PubMed GONUTS page
↑ ^16.0 ^16.1 Spector M et al. (2000) Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells. Exp Cell Res 258: 109-20 PubMed GONUTS page
↑ ^17.0 ^17.1 Sanz V et al. (2000) Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2. FEBS Lett 474: 169-74 PubMed GONUTS page
↑ Sofroniew MV et al. (2001) Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci 24: 1217-81 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 Passos JF et al. (2010) Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol 6: 347 PubMed GONUTS page
↑ Krauss RS et al. (2005) Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact. J Cell Sci 118: 2355-62 PubMed GONUTS page
↑ ^21.0 ^21.1 Evans IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell Signal 20: 1375-84 PubMed GONUTS page
↑ ^22.0 ^22.1 Mamik MK et al. (2011) HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation 8: 145 PubMed GONUTS page

[PMID:15276183-0] 1.0 ^1.1 Gangloff M & Gay NJ (2004) MD-2: the Toll 'gatekeeper' in endotoxin signalling. Trends Biochem Sci 29: 294-300 PubMed GONUTS page

[PMID:10878576-1] 2.0 ^2.1 Martín-Blanco E (2000) p38 MAPK signalling cascades: ancient roles and new functions. Bioessays 22: 637-45 PubMed GONUTS page

[PMID:8910365-2] 3.0 ^3.1 Kramer RM et al. (1996) p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2. J Biol Chem 271: 27723-9 PubMed GONUTS page

[PMID:9687510-3] 4.0 ^4.1 Deak M et al. (1998) Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J 17: 4426-41 PubMed GONUTS page

[PMID:7997261-4] 5.0 ^5.1 ^5.2 ^5.3 Lee JC et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372: 739-46 PubMed GONUTS page

[PMID:10706854-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Kampen GT et al. (2000) Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 95: 1911-7 PubMed GONUTS page

[PMID:12761180-6] 7.0 ^7.1 Takahashi M et al. (2003) Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. J Biochem 133: 181-7 PubMed GONUTS page

[PMID:16189514-7] 8.0 ^8.1 Rual JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437: 1173-8 PubMed GONUTS page

[PMID:16636664-8] 9.0 ^9.1 Wu Y et al. (2006) Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals. Oncogene 25: 5787-800 PubMed GONUTS page

[PMID:16751104-9] 10.0 ^10.1 Zohn IE et al. (2006) p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell 125: 957-69 PubMed GONUTS page

[PMID:17255097-10] 11.0 ^11.1 ter Haar E et al. (2007) Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. J Biol Chem 282: 9733-9 PubMed GONUTS page

[PMID:19776015-11] 12.0 ^12.1 Oya H et al. (2009) Phosphorylation of Williams syndrome transcription factor by MAPK induces a switching between two distinct chromatin remodeling complexes. J Biol Chem 284: 32472-82 PubMed GONUTS page

[PMID:20368287-12] 13.0 ^13.1 Pilot-Storck F et al. (2010) Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Mol Cell Proteomics 9: 1578-93 PubMed GONUTS page

[PMID:9792677-13] 14.0 ^14.1 Pierrat B et al. (1998) RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK). J Biol Chem 273: 29661-71 PubMed GONUTS page

[PMID:8846784-14] Ben-Levy R et al. (1995) Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. EMBO J 14: 5920-30 PubMed GONUTS page

[PMID:10912793-15] 16.0 ^16.1 Spector M et al. (2000) Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells. Exp Cell Res 258: 109-20 PubMed GONUTS page

[PMID:10838079-16] 17.0 ^17.1 Sanz V et al. (2000) Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2. FEBS Lett 474: 169-74 PubMed GONUTS page

[PMID:11520933-17] Sofroniew MV et al. (2001) Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci 24: 1217-81 PubMed GONUTS page

[PMID:20160708-18] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 Passos JF et al. (2010) Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol 6: 347 PubMed GONUTS page

[PMID:15923648-19] Krauss RS et al. (2005) Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact. J Cell Sci 118: 2355-62 PubMed GONUTS page

[PMID:18440775-20] 21.0 ^21.1 Evans IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell Signal 20: 1375-84 PubMed GONUTS page

[PMID:22027397-21] 22.0 ^22.1 Mamik MK et al. (2011) HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation 8: 145 PubMed GONUTS page

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