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HUMAN:MK08

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MAPK8 (synonyms: JNK1, PRKM8, SAPK1, SAPK1C)
Protein Name(s) Mitogen-activated protein kinase 8

MAP kinase 8 MAPK 8 JNK-46 Stress-activated protein kinase 1c SAPK1c Stress-activated protein kinase JNK1 c-Jun N-terminal kinase 1

External Links
UniProt P45983
EMBL L26318
U34822
U35004
U35005
DQ234352
AC016397
AC074325
AB451231
CH471187
CH471187
CH471187
CH471187
CH471187
CH471187
BC144063
CCDS CCDS60527.1
CCDS7223.1
CCDS7224.1
CCDS7225.1
CCDS7226.1
PIR S71097
S71099
RefSeq NP_001265476.1
NP_001265477.1
NP_002741.1
NP_620634.1
NP_620637.1
XP_006717980.1
XP_006717981.1
XP_006717982.1
UniGene Hs.138211
Hs.522924
PDB 1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4HYS
4HYU
4IZY
4L7F
4QTD
PDBsum 1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4HYS
4HYU
4IZY
4L7F
4QTD
ProteinModelPortal P45983
SMR P45983
BioGrid 111585
DIP DIP-249N
IntAct P45983
MINT MINT-1211982
STRING 9606.ENSP00000353483
BindingDB P45983
ChEMBL CHEMBL2096667
GuidetoPHARMACOLOGY 1496
PhosphoSite P45983
DMDM 2507195
MaxQB P45983
PaxDb P45983
PRIDE P45983
DNASU 5599
Ensembl ENST00000360332
ENST00000374176
ENST00000374179
ENST00000374182
ENST00000374189
ENST00000395611
GeneID 5599
KEGG hsa:5599
UCSC uc001jgo.3
uc001jgp.3
uc001jgq.3
uc009xoa.3
CTD 5599
GeneCards GC10P049514
HGNC HGNC:6881
HPA CAB004463
MIM 601158
neXtProt NX_P45983
PharmGKB PA283
eggNOG COG0515
GeneTree ENSGT00550000074271
HOVERGEN HBG014652
InParanoid P45983
KO K04440
OMA REHTLEQ
OrthoDB EOG7PCJGV
PhylomeDB P45983
TreeFam TF105100
BRENDA 2.7.11.24
Reactome REACT_13638
REACT_13643
REACT_163701
REACT_169436
REACT_2100
REACT_21326
REACT_21368
REACT_25299
SignaLink P45983
ChiTaRS MAPK8
EvolutionaryTrace P45983
GeneWiki MAPK8
GenomeRNAi 5599
NextBio 21738
PRO PR:P45983
Proteomes UP000005640
Bgee P45983
CleanEx HS_MAPK8
ExpressionAtlas P45983
Genevestigator P45983
GO GO:0005829
GO:0005739
GO:0005654
GO:0005634
GO:0005524
GO:0042826
GO:0035033
GO:0004705
GO:0004674
GO:0006915
GO:0097190
GO:0070301
GO:0071222
GO:0071260
GO:0071732
GO:0038095
GO:0045087
GO:0097193
GO:0007254
GO:0007258
GO:0002755
GO:0002756
GO:0043066
GO:0032091
GO:0048011
GO:0001503
GO:0018105
GO:0018107
GO:0043065
GO:0090045
GO:2000017
GO:0010628
GO:1900740
GO:0097300
GO:0031063
GO:0032880
GO:0051090
GO:0046686
GO:0006950
GO:0009411
GO:0051403
GO:0034166
GO:0034134
GO:0034138
GO:0034142
GO:0034146
GO:0034162
GO:0002224
GO:0038123
GO:0038124
GO:0035666
InterPro IPR011009
IPR003527
IPR008351
IPR000719
IPR002290
IPR008271
Pfam PF00069
PRINTS PR01772
SMART SM00220
SUPFAM SSF56112
PROSITE PS01351
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0097441

basal dendrite

PMID:22683681[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q91Y86

C

exists_during:(GO:0006468)

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:22683681[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q91Y86

C

exists_during:(GO:0006468)

Seeded From UniProt

complete

involved_in

GO:0071276

cellular response to cadmium ion

PMID:26514923[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034614

cellular response to reactive oxygen species

PMID:26514923[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034198

cellular response to amino acid starvation

PMID:11096076[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051403

stress-activated MAPK cascade

PMID:11096076[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:21856198[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902595

regulation of DNA replication origin binding

PMID:21856198[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031281

positive regulation of cyclase activity

PMID:22027397[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051247

positive regulation of protein metabolic process

PMID:22027397[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042752

regulation of circadian rhythm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q91Y86

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:22441692[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:14615289[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P12821

F

Seeded From UniProt

complete

involved_in

GO:0090045

positive regulation of deacetylase activity

PMID:20027304[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

PMID:20027304[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q96EB6

F

Seeded From UniProt

complete

enables

GO:0035033

histone deacetylase regulator activity

PMID:20027304[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032880

regulation of protein localization

PMID:20027304[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018107

peptidyl-threonine phosphorylation

PMID:20027304[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:20027304[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:15850461[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:22065586[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:20027304[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:15850461[9]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:Q6JBY9)

Seeded From UniProt

complete

involved_in

GO:0071260

cellular response to mechanical stimulus

PMID:19593445[11]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:21095239[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032091

negative regulation of protein binding

PMID:21095239[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018107

peptidyl-threonine phosphorylation

PMID:21095239[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:21095239[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007258

JUN phosphorylation

PMID:21095239[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007254

JNK cascade

PMID:8654373[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004705

JUN kinase activity

PMID:21095239[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004705

JUN kinase activity

PMID:8654373[13]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0051247

positive regulation of protein metabolic process

PMID:22027397[5]

ECO:0000315

P

Fig. 5B

complete
CACAO 2991

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21095239[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0031281

positive regulation of cyclase activity

PMID:22027397[5]

ECO:0000315

P

Fig. 5D

complete
CACAO 2992

enables

GO:0004674

protein serine/threonine kinase activity

PMID:20027304[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0071310

cellular response to organic substance

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001172432
RGD:70500

P

Seeded From UniProt

complete

involved_in

GO:0048666

neuron development

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000622286
RGD:621506
RGD:628847

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001171983
RGD:621506
RGD:628847

P

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000622286
RGD:628847

C

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106908
MGI:MGI:1201387
MGI:MGI:1201408
MGI:MGI:1346865
PANTHER:PTN000622075
RGD:3046
RGD:70500
RGD:71050
UniProtKB:P78362
UniProtKB:Q16539
UniProtKB:Q96SB4
UniProtKB:Q9UPZ9
WB:WBGene00004055
WB:WBGene00004056

P

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1346861
PANTHER:PTN000622075
UniProtKB:A9T142

P

Seeded From UniProt

complete

involved_in

GO:0009612

response to mechanical stimulus

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001171983
RGD:628847

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0052703
FB:FBgn0267339
MGI:MGI:1201408
MGI:MGI:1346347
MGI:MGI:1346858
MGI:MGI:1346859
MGI:MGI:1346861
MGI:MGI:1346862
MGI:MGI:1346863
MGI:MGI:1346865
MGI:MGI:1354946
MGI:MGI:2444559
PANTHER:PTN000622075
PomBase:SPAC24B11.06c
PomBase:SPBC119.08
PomBase:SPBC530.14c
RGD:3046
RGD:621506
RGD:628847
RGD:70500
RGD:70975
RGD:71050
SGD:S000000112
SGD:S000004103
SGD:S000004829
TAIR:locus:2024887
TAIR:locus:2124943
UniProtKB:A9T142
UniProtKB:O77306
UniProtKB:P28482
UniProtKB:P78362
UniProtKB:Q10N20
UniProtKB:Q13164
UniProtKB:Q96SB4
WB:WBGene00002178
WB:WBGene00002187
WB:WBGene00003048
WB:WBGene00003401
WB:WBGene00004056
WB:WBGene00004057

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003256
FB:FBgn0015765
MGI:MGI:1201387
MGI:MGI:1201408
MGI:MGI:1336881
MGI:MGI:1346347
MGI:MGI:1346858
MGI:MGI:1346859
MGI:MGI:1346861
MGI:MGI:1346865
MGI:MGI:1354946
MGI:MGI:1934157
MGI:MGI:2444559
MGI:MGI:96913
PANTHER:PTN000622075
PomBase:SPAC24B11.06c
PomBase:SPAC31G5.09c
PomBase:SPBC119.08
PomBase:SPBC530.14c
RGD:3046
RGD:3663
RGD:621505
RGD:621506
RGD:628675
RGD:628847
RGD:70496
RGD:70500
SGD:S000000112
SGD:S000001072
SGD:S000003272
SGD:S000003642
SGD:S000004103
TAIR:locus:2024887
TAIR:locus:2124943
UniProtKB:A9T142
UniProtKB:O77306
UniProtKB:P20794
UniProtKB:P28482
UniProtKB:P45983
UniProtKB:P78362
UniProtKB:Q10N20
UniProtKB:Q13164
UniProtKB:Q5AZN7
UniProtKB:Q8GYQ5
UniProtKB:Q96SB4
UniProtKB:Q9LV37
UniProtKB:Q9P419
WB:WBGene00002178
WB:WBGene00003048
WB:WBGene00003401
WB:WBGene00004055
WB:WBGene00004057
dictyBase:DDB_G0283903
dictyBase:DDB_G0286353

C

Seeded From UniProt

complete

enables

GO:0004707

MAP kinase activity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015765
FB:FBgn0024846
FB:FBgn0267339
MGI:MGI:1346858
MGI:MGI:1346859
MGI:MGI:1346865
MGI:MGI:1354946
PANTHER:PTN001172432
PomBase:SPAC31G5.09c
PomBase:SPBC119.08
RGD:1309340
RGD:3045
RGD:3046
RGD:621505
RGD:70496
RGD:70500
RGD:70975
SGD:S000000112
SGD:S000003272
SGD:S000006258
UniProtKB:A0A1D8PFT5
UniProtKB:A0A1D8PT38
UniProtKB:O15264
UniProtKB:P27361
UniProtKB:Q15759
UniProtKB:Q16539
WB:WBGene00003401
WB:WBGene00004055
WB:WBGene00004056
dictyBase:DDB_G0286353

F

Seeded From UniProt

complete

enables

GO:0004707

MAP kinase activity

PMID:21873635[14]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000183747
FB:FBgn0015765
FB:FBgn0024846
FB:FBgn0267339
MGI:MGI:1346858
MGI:MGI:1346859
MGI:MGI:1346865
MGI:MGI:1354946
PANTHER:PTN002372889
PomBase:SPAC31G5.09c
PomBase:SPBC119.08
RGD:1309340
RGD:3045
RGD:3046
RGD:621505
RGD:70496
RGD:70500
RGD:70975
SGD:S000000112
SGD:S000003272
SGD:S000006258
UniProtKB:A0A1D8PFT5
UniProtKB:A0A1D8PT38
UniProtKB:O15264
UniProtKB:P27361
UniProtKB:Q15759
UniProtKB:Q16539
WB:WBGene00003401
WB:WBGene00004055
WB:WBGene00004056
dictyBase:DDB_G0286353

F

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

PMID:23776175[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:14967141[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009411

response to UV

PMID:14967141[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007258

JUN phosphorylation

PMID:14967141[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:14967141[16]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:1900740

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:1900740

C

Seeded From UniProt

complete

involved_in

GO:0031063

regulation of histone deacetylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0035033

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004707

MAP kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003527
InterPro:IPR008351

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR003527
InterPro:IPR008351

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR003527
InterPro:IPR008271
InterPro:IPR008351

P

Seeded From UniProt

complete

enables

GO:0004707

MAP kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.24

F

Seeded From UniProt

complete

involved_in

GO:0016241

regulation of macroautophagy

PMID:26546165[17]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900740

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Reactome:R-HSA-139910
Reactome:R-HSA-111446

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0071345

cellular response to cytokine stimulus

Reactome:R-HSA-9007892

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051090

regulation of DNA-binding transcription factor activity

Reactome:R-HSA-450341

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

Reactome:R-HSA-193648

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038095

Fc-epsilon receptor signaling pathway

Reactome:R-HSA-2454202

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

Reactome:R-HSA-139918
Reactome:R-HSA-139908

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

involved_in

GO:0007254

JNK cascade

Reactome:R-HSA-450321

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-9008043
Reactome:R-HSA-451347
Reactome:R-HSA-450348
Reactome:R-HSA-205136
Reactome:R-HSA-205075
Reactome:R-HSA-193666
Reactome:R-HSA-168162
Reactome:R-HSA-139918
Reactome:R-HSA-139908

ECO:0000304

author statement supported by traceable reference used in manual assertion









C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-5683986
Reactome:R-HSA-450348
Reactome:R-HSA-193666
Reactome:R-HSA-168136
Reactome:R-HSA-168053

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

enables

GO:0004705

JUN kinase activity

Reactome:R-HSA-205075

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

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  2. 2.0 2.1 Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page
  3. 3.0 3.1 Ko, YG et al. (2001) Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J. Biol. Chem. 276 6030-6 PubMed GONUTS page
  4. 4.0 4.1 Miotto, B & Struhl, K (2011) JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. Mol. Cell 44 62-71 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Mamik, MK et al. (2011) HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation 8 145 PubMed GONUTS page
  6. Yoshitane, H et al. (2012) JNK regulates the photic response of the mammalian circadian clock. EMBO Rep. 13 455-61 PubMed GONUTS page
  7. Kohlstedt, K et al. (2004) Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ. Res. 94 60-7 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Nasrin, N et al. (2009) JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS ONE 4 e8414 PubMed GONUTS page
  9. 9.0 9.1 Eyers, CE et al. (2005) The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Biochem. J. 389 127-35 PubMed GONUTS page
  10. Oh, YT et al. (2012) Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J. Biol. Chem. 287 257-67 PubMed GONUTS page
  11. Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 12.4 12.5 12.6 Deng, H et al. (2011) Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells. Int. J. Biochem. Cell Biol. 43 409-15 PubMed GONUTS page
  13. 13.0 13.1 Gupta, S et al. (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15 2760-70 PubMed GONUTS page
  14. 14.00 14.01 14.02 14.03 14.04 14.05 14.06 14.07 14.08 14.09 14.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  15. Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 Yu, C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol. Cell 13 329-40 PubMed GONUTS page
  17. Maejima, Y et al. (2016) Regulation of autophagy by Beclin 1 in the heart. J. Mol. Cell. Cardiol. 95 19-25 PubMed GONUTS page