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HUMAN:MIF
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MIF (synonyms: GLIF, MMIF) | |
| Protein Name(s) | Macrophage migration inhibitory factor
MIF Glycosylation-inhibiting factor GIF L-dopachrome isomerase L-dopachrome tautomerase Phenylpyruvate tautomerase | |
| External Links | ||
| UniProt | P14174 | |
| EMBL | M25639 L10612 Z23063 L19686 AF469046 EF611126 CR456520 AK311929 CR407644 CR541651 BT007148 DQ307455 CH471095 BC000447 BC007676 BC008914 BC013976 BC022414 BC053376 M95775 | |
| IPI | IPI00293276 | |
| PIR | A48793 | |
| RefSeq | NP_002406.1 | |
| UniGene | Hs.407995 | |
| PDB | 1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V | |
| PDBsum | 1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V | |
| ProteinModelPortal | P14174 | |
| SMR | P14174 | |
| IntAct | P14174 | |
| MINT | MINT-5000040 | |
| STRING | P14174 | |
| PhosphoSite | P14174 | |
| DMDM | 1170955 | |
| SWISS-2DPAGE | P14174 | |
| Siena-2DPAGE | P14174 | |
| PeptideAtlas | P14174 | |
| PRIDE | P14174 | |
| Ensembl | ENST00000215754 | |
| GeneID | 4282 | |
| KEGG | hsa:4282 | |
| UCSC | uc002zyr.1 | |
| CTD | 4282 | |
| GeneCards | GC22P024236 | |
| H-InvDB | HIX0041297 | |
| HGNC | HGNC:7097 | |
| HPA | CAB005284 HPA003868 | |
| MIM | 153620 604302 | |
| neXtProt | NX_P14174 | |
| Orphanet | 85414 | |
| PharmGKB | PA30819 | |
| eggNOG | prNOG20415 | |
| GeneTree | ENSGT00530000063544 | |
| HOVERGEN | HBG003240 | |
| InParanoid | P14174 | |
| OrthoDB | EOG49GKJ5 | |
| PhylomeDB | P14174 | |
| NextBio | 16845 | |
| ArrayExpress | P14174 | |
| CleanEx | HS_MIF | |
| Genevestigator | P14174 | |
| GO | GO:0009986 GO:0005737 GO:0005615 GO:0043498 GO:0042056 GO:0005125 GO:0005126 GO:0004167 GO:0050178 GO:0008283 GO:0007166 GO:0006954 GO:0045087 GO:0043066 GO:0090344 GO:0071157 GO:0043518 GO:0010629 GO:0030890 GO:0050715 GO:0070374 GO:0048146 GO:0033138 GO:0050731 GO:0010739 GO:0001516 GO:0070207 GO:0043030 | |
| InterPro | IPR001398 IPR019829 IPR014347 | |
| Gene3D | G3DSA:3.30.429.10 | |
| KO | K07253 | |
| PANTHER | PTHR11954 | |
| Pfam | PF01187 | |
| ProDom | PD004816 | |
| SUPFAM | SSF55331 | |
| PROSITE | PS01158 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001516 |
prostaglandin biosynthetic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0004167 |
dopachrome isomerase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004167 |
dopachrome isomerase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005102 |
receptor binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005125 |
cytokine activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005125 |
cytokine activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005126 |
cytokine receptor binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0243 |
C |
Seeded From UniProt |
|||
| GO:0005576 |
extracellular region |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005615 |
extracellular space |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0006954 |
inflammatory response |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007166 |
cell surface receptor signaling pathway |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0008283 |
cell proliferation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0009986 |
cell surface |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0010629 |
negative regulation of gene expression |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0010739 |
positive regulation of protein kinase A signaling cascade |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0016853 |
isomerase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0019752 |
carboxylic acid metabolic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0030890 |
positive regulation of B cell proliferation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0042056 |
chemoattractant activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0042327 |
positive regulation of phosphorylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043030 |
regulation of macrophage activation |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0043066 |
negative regulation of apoptotic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043066 |
negative regulation of apoptotic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043498 |
cell surface binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0043518 |
negative regulation of DNA damage response, signal transduction by p53 class mediator |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0045087 |
innate immune response |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0048146 |
positive regulation of fibroblast proliferation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0050178 |
phenylpyruvate tautomerase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0050178 |
phenylpyruvate tautomerase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0050715 |
positive regulation of cytokine secretion |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0050918 |
positive chemotaxis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0070207 |
protein homotrimerization |
IPI: Inferred from Physical Interaction |
P |
Seeded From UniProt |
||||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0071157 |
negative regulation of cell cycle arrest |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0090344 |
negative regulation of cell aging |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 Leng L et al. (2003) MIF signal transduction initiated by binding to CD74. J Exp Med 197: 1467-76 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Crichlow GV et al. (2007) Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J Biol Chem 282: 23089-95 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Shi X et al. (2006) CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 25: 595-606 PubMed GONUTS page
- ↑ Shen L et al. (2003) The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. FEBS Lett 540: 86-90 PubMed GONUTS page
- ↑ Liu L et al. (2008) Macrophage migration inhibitory factor (MIF) interacts with Bim and inhibits Bim-mediated apoptosis. Mol Cells 26: 193-9 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Hudson JD et al. (1999) A proinflammatory cytokine inhibits p53 tumor suppressor activity. J Exp Med 190: 1375-82 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Verjans E et al. (2009) Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer. BMC Cancer 9: 230 PubMed GONUTS page
- ↑ Wilson JM et al. (2005) Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology 129: 1485-503 PubMed GONUTS page
