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HUMAN:MECP2
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (taxon:9606) | |
| Gene Name(s) | MECP2 | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | MECP2_HUMAN | |
| UniProt Accessions | P51608, O15233, Q6QHH9, Q7Z384, | |
| EMBL | L37298, X99686, AJ132917, AF158180, Y12643, AY541280, BX538060, AF030876, BC011612, X89430, X94628, | |
| RefSeq | NP_001104262.1, NP_004983.1, | |
| PDB | 1QK9, 3C2I, | |
| IntAct | P51608, | |
| Ensembl | ENST00000303391, | |
| Pfam | PF01429, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
TAS: Traceable Author Statement |
|
P |
||||
| GO:0000792 |
heterochromatin |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
TAS: Traceable Author Statement |
|
F |
||||
| GO:0003714 |
transcription corepressor activity |
TAS: Traceable Author Statement |
|
F |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
||||
| GO:0005634 |
nucleus |
TAS: Traceable Author Statement |
|
C |
||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0010385 |
double-stranded methylated DNA binding |
IMP: Inferred from Mutant Phenotype |
|
F |
||||
| GO:0016564 |
transcription repressor activity |
IDA: Inferred from Direct Assay |
|
F |
||||
| GO:0019904 |
protein domain specific binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
IDA: Inferred from Direct Assay |
|
P |
||||
| GO:0047485 |
protein N-terminus binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0007420 |
DNA methylation |
IMP: Inferred from Mutant Phenotype |
P |
Figure 3. Bisulfite sequencing analysis of MECP2 promoter methylation in frontal cortex DNA from autism and control postmortem brain samples. |
complete | |||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
TAS: Traceable Author Statement |
P |
|||||
| GO:0000792 |
heterochromatin |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
TAS: Traceable Author Statement |
F |
|||||
| GO:0003714 |
transcription corepressor activity |
TAS: Traceable Author Statement |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
||||
| GO:0005634 |
nucleus |
TAS: Traceable Author Statement |
C |
|||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0010385 |
double-stranded methylated DNA binding |
IMP: Inferred from Mutant Phenotype |
F |
|||||
| GO:0019904 |
protein domain specific binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0047485 |
protein N-terminus binding |
IPI: Inferred from Physical Interaction |
F |
| ||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Nan X et al. (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393: 386-9 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 Kokura K et al. (2001) The Ski protein family is required for MeCP2-mediated transcriptional repression. J Biol Chem 276: 34115-21 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Yu F et al. (2000) Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. Nucleic Acids Res 28: 2201-6 PubMed GONUTS page
- ↑ 4.0 4.1 Harikrishnan KN et al. (2005) Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing. Nat Genet 37: 254-64 PubMed GONUTS page
- ↑ 5.0 5.1 Simpson JC et al. (2000) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep 1: 287-92 PubMed GONUTS page
- ↑ 6.0 6.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
- ↑ 7.0 7.1 Nan X et al. (2007) Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc Natl Acad Sci U S A 104: 2709-14 PubMed GONUTS page
- ↑ Nagarajan RP et al. (2006) Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation. Epigenetics 1: e1-11 PubMed GONUTS page
