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HUMAN:MDR1
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | ABCB1 (synonyms: MDR1, PGY1) | |
| Protein Name(s) | Multidrug resistance protein 1
ATP-binding cassette sub-family B member 1 P-glycoprotein 1 | |
| External Links | ||
| EMBL | M14758 M29447 M29424 M29425 M29426 M29427 M29428 M29429 M29430 M29431 M29432 M29433 M29434 M29435 M29436 M29437 M29438 M29439 M29440 M29441 M29442 M29443 M29444 M29445 M29446 AF016535 AY910577 AK290159 AC002457 AC005068 M37724 M37725 X58723 | |
| IPI | IPI00027481 | |
| PIR | A34914 | |
| RefSeq | NP_000918.2 | |
| UniGene | Hs.489033 | |
| ProteinModelPortal | P08183 | |
| SMR | P08183 | |
| IntAct | P08183 | |
| MINT | MINT-5000901 | |
| STRING | P08183 | |
| TCDB | 3.A.1.201.1 | |
| PhosphoSite | P08183 | |
| PRIDE | P08183 | |
| Ensembl | ENST00000265724 | |
| GeneID | 5243 | |
| KEGG | hsa:5243 | |
| CTD | 5243 | |
| GeneCards | GC07M081743 | |
| H-InvDB | HIX0033521 | |
| HGNC | HGNC:40 | |
| HPA | CAB001716 HPA002199 | |
| MIM | 120080 171050 612244 | |
| neXtProt | NX_P08183 | |
| HOGENOM | HBG758042 | |
| HOVERGEN | HBG080809 | |
| InParanoid | P08183 | |
| OMA | IRKRSTR | |
| OrthoDB | EOG42FSGR | |
| PhylomeDB | P08183 | |
| Pathway_Interaction_DB | hif1_tfpathway | |
| DrugBank | DB00171 DB00802 DB01169 DB01072 DB01136 DB01394 DB00091 DB00694 DB00975 DB01196 DB00875 DB00619 DB01167 DB00622 DB01182 DB01103 DB00908 DB00243 DB01045 DB00778 DB01232 DB00675 DB00570 | |
| NextBio | 20254 | |
| ArrayExpress | P08183 | |
| Bgee | P08183 | |
| CleanEx | HS_ABCB1 | |
| Genevestigator | P08183 | |
| GermOnline | ENSG00000085563 | |
| GO | GO:0016324 GO:0009986 GO:0000139 GO:0016021 GO:0046581 GO:0005624 GO:0005524 GO:0005515 GO:0008559 | |
| InterPro | IPR003439 IPR017871 IPR017940 IPR001140 IPR011527 IPR003593 | |
| Pfam | PF00664 PF00005 | |
| SMART | SM00382 | |
| SUPFAM | SSF90123 | |
| PROSITE | PS50929 PS00211 PS50893 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000086 |
G2/M transition of mitotic cell cycle |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0000139 |
Golgi membrane |
PANTHER:PTHR24221_AN15 |
C |
Seeded From UniProt |
||||
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005215 |
transporter activity |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005624 |
membrane fraction |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0006200 |
ATP catabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006200 |
ATP catabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006810 |
transport |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0008559 |
xenobiotic-transporting ATPase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0009986 |
cell surface |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0009986 |
cell surface |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0162 |
C |
Seeded From UniProt |
|||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
PANTHER:PTHR24221_AN0 |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0016324 |
apical plasma membrane |
PANTHER:PTHR24221_AN15 |
C |
Seeded From UniProt |
||||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016887 |
ATPase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016887 |
ATPase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0017111 |
nucleoside-triphosphatase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0042493 |
response to drug |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0042626 |
ATPase activity, coupled to transmembrane movement of substances |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0042626 |
ATPase activity, coupled to transmembrane movement of substances |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0042626 |
ATPase activity, coupled to transmembrane movement of substances |
PANTHER:PTHR24221_AN0 |
F |
Seeded From UniProt |
||||
| GO:0042626 |
ATPase activity, coupled to transmembrane movement of substances |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0046581 |
intercellular canaliculus |
PANTHER:PTHR24221_AN15 |
C |
Seeded From UniProt |
||||
| GO:0055085 |
transmembrane transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0055085 |
transmembrane transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0055085 |
transmembrane transport |
PANTHER:PTHR24221_AN0 |
P |
Seeded From UniProt |
||||
| GO:0072089 |
stem cell proliferation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Yamamoto A et al. (2009) ABCB1 is predominantly expressed in human fetal neural stem/progenitor cells at an early development stage. J Neurosci Res 87: 2615-23 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Gros P et al. (1986) Isolation and expression of a complementary DNA that confers multidrug resistance. Nature 323: 728-31 PubMed GONUTS page
- ↑ Rao PS et al. (2006) RNF2 interacts with the linker region of the human P-glycoprotein. Int J Oncol 29: 1413-9 PubMed GONUTS page
- ↑ Li L et al. (2010) LAPTM4B: a novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling. Oncogene 29: 5785-95 PubMed GONUTS page
- ↑ 5.0 5.1 Gros P et al. (1986) Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47: 371-80 PubMed GONUTS page
- ↑ Shin BK et al. (2003) Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J Biol Chem 278: 7607-16 PubMed GONUTS page
