HUMAN:MBL2

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	MBL2 ( synonyms: COLEC1, MBL )
Protein Name(s)	Mannose-binding protein C MBP-C Collectin-1 MBP1 Mannan-binding protein Mannose-binding lectin
External Links
UniProt Identifier	MBL2_HUMAN
UniProt Accessions	P11226, Q4VB12, Q4VB13, Q86SI4, Q96KE4, Q96TF7, Q96TF8, Q96TF9,
EMBL	X15422, X15954, X15955, X15956, X15957, AF080510, AF080508, AF080509, Y16576, Y16577, Y16578, Y16579, Y16580, Y16581, Y16582, AF360991, BC069338, BC096181, BC096182, AF482699, AF482700,
PIR	JL0115,
RefSeq	NP_000233.1,
PDB	1HUP,
Ensembl	ENST00000373968,
Pfam	PF01391, PF00059,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0001867	complement activation, lectin pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1018	P
	GO:0001867	complement activation, lectin pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025797	P
	GO:0001867	complement activation, lectin pathway	PMID:11532276^[1]	EXP: Inferred from Experiment		P
	GO:0001867	complement activation, lectin pathway	PMID:11549596^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P04264	P
	GO:0001867	complement activation, lectin pathway	PMID:15148336^[3]	IDA: Inferred from Direct Assay		P
	GO:0005102	receptor binding	PMID:11549596^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P04264	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001304	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016186	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016187	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018378	F
	GO:0005515	protein binding	PMID:11485744^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P48740-2	F
	GO:0005529	sugar binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0430	F
	GO:0005537	mannose binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0465	F
	GO:0005537	mannose binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000047103	F
	GO:0005537	mannose binding	PMID:11549596^[2]	NAS: Non-traceable Author Statement		F
	GO:0005537	mannose binding	PMID:2477488^[5]	TAS: Traceable Author Statement		F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	PMID:10639434^[6]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	PMID:10925294^[7]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	Reactome:REACT_7959	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_8002	TAS: Traceable Author Statement		C
	GO:0005581	collagen	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0176	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025797	C
	GO:0005615	extracellular space	PMID:1304173^[8]	TAS: Traceable Author Statement		C
	GO:0006953	acute-phase response	PMID:2477488^[5]	TAS: Traceable Author Statement		P
	GO:0006956	complement activation	Reactome:REACT_8024	TAS: Traceable Author Statement		P
	GO:0006958	complement activation, classical pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0180	P
	GO:0006979	response to oxidative stress	PMID:11549596^[2]	NAS: Non-traceable Author Statement		P
	GO:0008228	opsonization	PMID:2477488^[5]	TAS: Traceable Author Statement		P
	GO:0043499	eukaryotic cell surface binding	PMID:2477488^[5]	TAS: Traceable Author Statement		F
	GO:0043621	protein self-association	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000047103	F
	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025797	P
	GO:0044130	negative regulation of growth of symbiont in host	PMID:15148336^[3]	IDA: Inferred from Direct Assay		P
	GO:0045087	innate immune response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0399	P
	GO:0045087	innate immune response	Reactome:REACT_6802	TAS: Traceable Author Statement		P
	GO:0048306	calcium-dependent protein binding	PMID:12421953^[9]	IPI: Inferred from Physical Interaction	UniProtKB:O00187	F
	GO:0048306	calcium-dependent protein binding	PMID:12421953^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P48740	F
	GO:0048306	calcium-dependent protein binding	PMID:18596036^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P48740	F
	GO:0050766	positive regulation of phagocytosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025797	P
	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025797	P
	GO:0050830	defense response to Gram-positive bacterium	PMID:15148336^[3]	IDA: Inferred from Direct Assay		P
	GO:0051635	bacterial cell surface binding	PMID:2477488^[5]	TAS: Traceable Author Statement		F
	GO:0051873	killing by host of symbiont cells	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025797	P
	GO:0001867	complement activation, lectin pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1018	P
	GO:0001867	complement activation, lectin pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025797	P
	GO:0001867	complement activation, lectin pathway	PMID:11549596^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P04264	P
	GO:0001867	complement activation, lectin pathway	PMID:15148336^[3]	IDA: Inferred from Direct Assay		P
	GO:0001867	complement activation, lectin pathway	Reactome:REACT_7964	TAS: Traceable Author Statement		P
	GO:0005102	receptor binding	PMID:11549596^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P04264	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001304	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016186	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016187	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018378	F
	GO:0005515	protein binding	PMID:11485744^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P48740-2	F
	GO:0005529	sugar binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0430	F
	GO:0005537	mannose binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0465	F
	GO:0005537	mannose binding	PMID:11549596^[2]	NAS: Non-traceable Author Statement		F
	GO:0005537	mannose binding	PMID:2477488^[5]	TAS: Traceable Author Statement		F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	Reactome:REACT_7959	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_7965	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_7983	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_8002	TAS: Traceable Author Statement		C
	GO:0005581	collagen	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0176	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025797	C
	GO:0005615	extracellular space	PMID:1304173^[8]	TAS: Traceable Author Statement		C
	GO:0006953	acute-phase response	PMID:2477488^[5]	TAS: Traceable Author Statement		P
	GO:0006956	complement activation	Reactome:REACT_8024	TAS: Traceable Author Statement		P
	GO:0006958	complement activation, classical pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0180	P
	GO:0006979	response to oxidative stress	PMID:11549596^[2]	NAS: Non-traceable Author Statement		P
	GO:0008228	opsonization	PMID:2477488^[5]	TAS: Traceable Author Statement		P
	GO:0043499	eukaryotic cell surface binding	PMID:2477488^[5]	TAS: Traceable Author Statement		F
	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025797	P
	GO:0044130	negative regulation of growth of symbiont in host	PMID:15148336^[3]	IDA: Inferred from Direct Assay		P
	GO:0045087	innate immune response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0399	P
	GO:0045087	innate immune response	Reactome:REACT_6802	TAS: Traceable Author Statement		P
	GO:0048306	calcium-dependent protein binding	PMID:12421953^[9]	IPI: Inferred from Physical Interaction	UniProtKB:O00187	F
	GO:0048306	calcium-dependent protein binding	PMID:12421953^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P48740	F
	GO:0048306	calcium-dependent protein binding	PMID:18596036^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P48740	F
	GO:0050766	positive regulation of phagocytosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025797	P
	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025797	P
	GO:0050830	defense response to Gram-positive bacterium	PMID:15148336^[3]	IDA: Inferred from Direct Assay		P
	GO:0051635	bacterial cell surface binding	PMID:2477488^[5]	TAS: Traceable Author Statement		F
	GO:0051873	killing by host of symbiont cells	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000025797	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Petersen SV et al. (2001) The mannan-binding lectin pathway of complement activation: biology and disease association. Mol Immunol 38: 133-49 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Collard CD et al. (2001) Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1. Am J Pathol 159: 1045-54 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Shi L et al. (2004) Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J Exp Med 199: 1379-90 PubMed GONUTS page
↑ ^4.0 ^4.1 Dahl MR et al. (2001) MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity 15: 127-35 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Wright SD et al. (1989) Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J Exp Med 170: 1231-41 PubMed GONUTS page
↑ Neth O et al. (2000) Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun 68: 688-93 PubMed GONUTS page
↑ Vorup-Jensen T et al. (2000) Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2. J Immunol 165: 2093-100 PubMed GONUTS page
↑ ^8.0 ^8.1 Lipscombe RJ et al. (1992) High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene. Hum Mol Genet 1: 709-15 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Cseh S et al. (2002) Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. J Immunol 169: 5735-43 PubMed GONUTS page
↑ ^10.0 ^10.1 Teillet F et al. (2008) Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J Biol Chem 283: 25715-24 PubMed GONUTS page

[PMID:11532276-0] Petersen SV et al. (2001) The mannan-binding lectin pathway of complement activation: biology and disease association. Mol Immunol 38: 133-49 PubMed GONUTS page

[PMID:11549596-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Collard CD et al. (2001) Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1. Am J Pathol 159: 1045-54 PubMed GONUTS page

[PMID:15148336-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Shi L et al. (2004) Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J Exp Med 199: 1379-90 PubMed GONUTS page

[PMID:11485744-3] 4.0 ^4.1 Dahl MR et al. (2001) MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity 15: 127-35 PubMed GONUTS page

[PMID:2477488-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Wright SD et al. (1989) Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J Exp Med 170: 1231-41 PubMed GONUTS page

[PMID:10639434-5] Neth O et al. (2000) Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun 68: 688-93 PubMed GONUTS page

[PMID:10925294-6] Vorup-Jensen T et al. (2000) Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2. J Immunol 165: 2093-100 PubMed GONUTS page

[PMID:1304173-7] 8.0 ^8.1 Lipscombe RJ et al. (1992) High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene. Hum Mol Genet 1: 709-15 PubMed GONUTS page

[PMID:12421953-8] 9.0 ^9.1 ^9.2 ^9.3 Cseh S et al. (2002) Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. J Immunol 169: 5735-43 PubMed GONUTS page

[PMID:18596036-9] 10.0 ^10.1 Teillet F et al. (2008) Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J Biol Chem 283: 25715-24 PubMed GONUTS page

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HUMAN:MBL2

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