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HUMAN:M4K4
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | MAP4K4 (synonyms: HGK, KIAA0687, NIK) | |
| Protein Name(s) | Mitogen-activated protein kinase kinase kinase kinase 4
HPK/GCK-like kinase HGK MAPK/ERK kinase kinase kinase 4 MEK kinase kinase 4 MEKKK 4 Nck-interacting kinase | |
| External Links | ||
| EMBL | AF096300 AY212247 AB014587 AL137755 AB013385 | |
| IPI | IPI00006752 IPI00219799 IPI00219800 IPI00219802 IPI00639883 | |
| PIR | T46481 | |
| RefSeq | NP_001229488.1 NP_004825.3 NP_663720.1 | |
| UniGene | Hs.431550 | |
| ProteinModelPortal | O95819 | |
| SMR | O95819 | |
| IntAct | O95819 | |
| STRING | O95819 | |
| PhosphoSite | O95819 | |
| PRIDE | O95819 | |
| Ensembl | ENST00000347699 | |
| GeneID | 9448 | |
| KEGG | hsa:9448 | |
| UCSC | uc002tbd.1 uc002tbe.1 uc002tbg.1 | |
| CTD | 9448 | |
| GeneCards | GC02P096078 | |
| HGNC | HGNC:6866 | |
| HPA | HPA008476 | |
| MIM | 604666 | |
| neXtProt | NX_O95819 | |
| PharmGKB | PA30612 | |
| eggNOG | prNOG18377 | |
| HOVERGEN | HBG036506 | |
| PhylomeDB | O95819 | |
| Pathway_Interaction_DB | ceramidepathway ephbfwdpathway tnfpathway | |
| NextBio | 35392 | |
| ArrayExpress | O95819 | |
| Bgee | O95819 | |
| CleanEx | HS_MAP4K4 | |
| Genevestigator | O95819 | |
| GermOnline | ENSG00000071054 | |
| GO | GO:0005737 GO:0005524 GO:0005515 GO:0004674 GO:0005083 GO:0007243 GO:0046328 GO:0006950 | |
| InterPro | IPR001180 IPR011009 IPR000719 IPR017441 IPR017442 IPR008271 IPR002290 | |
| Pfam | PF00780 PF00069 | |
| SMART | SM00036 SM00220 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS50219 PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005083 |
small GTPase regulator activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006950 |
response to stress |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0007243 |
intracellular protein kinase cascade |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0016301 |
kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016310 |
phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0046328 |
regulation of JNK cascade |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043066 |
negative regulation of apoptotic process |
IMP: Inferred from Mutant Phenotype |
P |
Figure 2D shows that MAP4K4 deals with apoptotic activity. |
complete | |||
| GO:0046329 |
negative regulation of JNK cascade |
IMP: Inferred from Mutant Phenotype |
P |
Figure 1C |
complete | |||
| GO:0097179 |
protease inhibitor complex |
IMP: Inferred from Mutant Phenotype |
C |
Figure 3C |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Yao Z et al. (1999) A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. J Biol Chem 274: 2118-25 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Machida N et al. (2004) Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. J Biol Chem 279: 15711-4 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Liu AW et al. (2011) ShRNA-targeted MAP4K4 inhibits hepatocellular carcinoma growth. Clin Cancer Res 17: 710-20 PubMed GONUTS page
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