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HUMAN:LYRIC
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | MTDH (synonyms: AEG1, LYRIC) | |
| Protein Name(s) | Protein LYRIC
3D3/LYRIC Astrocyte elevated gene-1 protein AEG-1 Lysine-rich CEACAM1 co-isolated protein Metadherin Metastasis adhesion protein | |
| External Links | ||
| EMBL | AF501310 AY082966 AF411226 AY974040 BC009324 BC014977 BC045642 AK000745 | |
| IPI | IPI00328715 | |
| RefSeq | NP_848927.2 | |
| UniGene | Hs.377155 | |
| ProteinModelPortal | Q86UE4 | |
| IntAct | Q86UE4 | |
| STRING | Q86UE4 | |
| PhosphoSite | Q86UE4 | |
| PeptideAtlas | Q86UE4 | |
| PRIDE | Q86UE4 | |
| Ensembl | ENST00000336273 | |
| GeneID | 92140 | |
| KEGG | hsa:92140 | |
| UCSC | uc003yhz.1 | |
| CTD | 92140 | |
| GeneCards | GC08P093862 | |
| H-InvDB | HIX0007668 | |
| HGNC | HGNC:29608 | |
| HPA | HPA010932 HPA015104 | |
| MIM | 610323 | |
| neXtProt | NX_Q86UE4 | |
| PharmGKB | PA142671307 | |
| eggNOG | prNOG06200 | |
| GeneTree | ENSGT00390000004343 | |
| HOGENOM | HBG444888 | |
| HOVERGEN | HBG052379 | |
| InParanoid | Q86UE4 | |
| OMA | KKKQGED | |
| OrthoDB | EOG4WWRJD | |
| PhylomeDB | Q86UE4 | |
| NextBio | 77609 | |
| ArrayExpress | Q86UE4 | |
| Bgee | Q86UE4 | |
| CleanEx | HS_MTDH | |
| Genevestigator | Q86UE4 | |
| GermOnline | ENSG00000147649 | |
| GO | GO:0016324 GO:0005789 GO:0016021 GO:0046581 GO:0016604 GO:0031965 GO:0005730 GO:0048471 GO:0005923 GO:0051059 GO:0001085 GO:0003713 GO:0031663 GO:0043066 GO:0000122 GO:0045766 GO:0010508 GO:0043123 GO:0051092 GO:0051897 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0001085 |
RNA polymerase II transcription factor binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0003713 |
transcription coactivator activity |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005730 |
nucleolus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000022865 |
C |
Seeded From UniProt |
|||
| GO:0005730 |
nucleolus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0188 |
C |
Seeded From UniProt |
|||
| GO:0005730 |
nucleolus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005783 |
endoplasmic reticulum |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005783 |
endoplasmic reticulum |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000022865 |
C |
Seeded From UniProt |
|||
| GO:0005783 |
endoplasmic reticulum |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005783 |
endoplasmic reticulum |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005783 |
endoplasmic reticulum |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005789 |
endoplasmic reticulum membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000022865 |
C |
Seeded From UniProt |
|||
| GO:0005789 |
endoplasmic reticulum membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0097 |
C |
Seeded From UniProt |
|||
| GO:0005789 |
endoplasmic reticulum membrane |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005923 |
tight junction |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005923 |
tight junction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000009989 |
C |
Seeded From UniProt |
|||
| GO:0005923 |
tight junction |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0265 |
C |
Seeded From UniProt |
|||
| GO:0005923 |
tight junction |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0010508 |
positive regulation of autophagy |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016324 |
apical plasma membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000009989 |
C |
Seeded From UniProt |
|||
| GO:0016324 |
apical plasma membrane |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0016604 |
nuclear body |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0030054 |
cell junction |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0031965 |
nuclear membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0182 |
C |
Seeded From UniProt |
|||
| GO:0043066 |
negative regulation of apoptosis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0045766 |
positive regulation of angiogenesis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0046581 |
intercellular canaliculus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000009989 |
C |
Seeded From UniProt |
|||
| GO:0046581 |
intercellular canaliculus |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0048471 |
perinuclear region of cytoplasm |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000022865 |
C |
Seeded From UniProt |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0198 |
C |
Seeded From UniProt |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0051059 |
NF-kappaB binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0051897 |
positive regulation of protein kinase B signaling cascade |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0070830 |
tight junction assembly |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000009989 |
P |
Seeded From UniProt |
|||
| GO:0019059 |
initiation of viral infection |
IDA: Inferred from Direct Assay |
P |
According to the results Lyric is a major cellular interaction partner of HIV-1 Gag and hint at a potential role in regulating infectivity. (Figure 5) |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Kang DC et al. (2005) Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. Gene 353: 8-15 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Sarkar D et al. (2008) Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 68: 1478-84 PubMed GONUTS page
- ↑ Ash SC et al. (2008) LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. Biochem Biophys Res Commun 371: 333-8 PubMed GONUTS page
- ↑ Carnemolla A et al. (2009) Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease. J Biol Chem 284: 18167-73 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Thirkettle HJ et al. (2009) Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression. Oncogene 28: 3663-70 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Emdad L et al. (2006) Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Res 66: 1509-16 PubMed GONUTS page
- ↑ 7.0 7.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
- ↑ 8.0 8.1 Sutherland HG et al. (2004) 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp Cell Res 294: 94-105 PubMed GONUTS page
- ↑ Bhutia SK et al. (2010) Astrocyte elevated gene-1 induces protective autophagy. Proc Natl Acad Sci U S A 107: 22243-8 PubMed GONUTS page
- ↑ Khuda II et al. (2009) Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling. Immunology 128: e700-6 PubMed GONUTS page
- ↑ 11.0 11.1 Lee SG et al. (2008) Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 27: 1114-21 PubMed GONUTS page
- ↑ Emdad L et al. (2009) Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc Natl Acad Sci U S A 106: 21300-5 PubMed GONUTS page
- ↑ Engeland CE et al. (2011) The cellular protein lyric interacts with HIV-1 Gag. J Virol 85: 13322-32 PubMed GONUTS page
