HUMAN:LRP8

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	LRP8 ( synonyms: APOER2 )
Protein Name(s)	Low-density lipoprotein receptor-related protein 8 LRP-8 Apolipoprotein E receptor 2
External Links
UniProt Identifier	LRP8_HUMAN
UniProt Accessions	Q14114, B1AMT6, B1AMT7, B1AMT8, O14968, Q86V27, Q99876, Q9BR78,
EMBL	D50678, D86407, D86407, Z75190, AL606760, AL355483, AL606760, AL355483, AL355483, AL606760, AL606760, AL355483, AL355483, AL606760, AL355483, AL606760, BC006443, BC051836,
RefSeq	NP_001018064.1, NP_004622.2, NP_059992.3, NP_150643.2,
PDB	3A7Q,
IntAct	Q14114,
Ensembl	ENST00000306052,
Pfam	PF00057, PF00058,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0004888	transmembrane receptor activity	PMID:8626535^[1]	TAS: Traceable Author Statement		F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001881	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018097	F
	GO:0005515	protein binding	PMID:12950167^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P02649	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000102343	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:10380922^[3]	NAS: Non-traceable Author Statement		C
	GO:0005886	plasma membrane	PMID:15459198^[4]	EXP: Inferred from Experiment		C
	GO:0005901	caveola	PMID:11369809^[5]	IDA: Inferred from Direct Assay		C
	GO:0006508	proteolysis	PMID:11152697^[6]	NAS: Non-traceable Author Statement		P
	GO:0006629	lipid metabolic process	PMID:11152697^[6]	NAS: Non-traceable Author Statement		P
	GO:0006629	lipid metabolic process	PMID:8626535^[1]	TAS: Traceable Author Statement		P
	GO:0006897	endocytosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0254	P
	GO:0006897	endocytosis	PMID:8626535^[1]	IDA: Inferred from Direct Assay		P
	GO:0007165	signal transduction	PMID:10380922^[3]	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000033	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	PMID:11152697^[6]	IC: Inferred by Curator	GO:0030229	C
	GO:0019221	cytokine-mediated signaling pathway	PMID:11152697^[6]	NAS: Non-traceable Author Statement		P
	GO:0021766	hippocampus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000102343	P
	GO:0021819	layer formation in cerebral cortex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000102343	P
	GO:0030168	platelet activation	Reactome:REACT_798	TAS: Traceable Author Statement		P
	GO:0030229	very-low-density lipoprotein particle receptor activity	PMID:8626535^[1]	IDA: Inferred from Direct Assay		F
	GO:0034187	apolipoprotein E binding	PMID:8626535^[1]	IC: Inferred by Curator	GO:0030229	F
	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000102343	P
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0004888	transmembrane signaling receptor activity	PMID:8626535^[1]	TAS: Traceable Author Statement		F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001881	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018097	F
	GO:0005515	protein binding	PMID:12950167^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P02649	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:10380922^[3]	NAS: Non-traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_23918	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_23972	TAS: Traceable Author Statement		C
	GO:0005901	caveola	PMID:11369809^[5]	IDA: Inferred from Direct Assay		C
	GO:0006508	proteolysis	PMID:11152697^[6]	NAS: Non-traceable Author Statement		P
	GO:0006629	lipid metabolic process	PMID:11152697^[6]	NAS: Non-traceable Author Statement		P
	GO:0006629	lipid metabolic process	PMID:8626535^[1]	TAS: Traceable Author Statement		P
	GO:0006897	endocytosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0254	P
	GO:0006897	endocytosis	PMID:8626535^[1]	IDA: Inferred from Direct Assay		P
	GO:0007165	signal transduction	PMID:10380922^[3]	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	PMID:11152697^[6]	IC: Inferred by Curator	GO:0030229	C
	GO:0019221	cytokine-mediated signaling pathway	PMID:11152697^[6]	NAS: Non-traceable Author Statement		P
	GO:0021766	hippocampus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000102343	P
	GO:0021819	layer formation in cerebral cortex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000102343	P
	GO:0030168	platelet activation	Reactome:REACT_798	TAS: Traceable Author Statement		P
	GO:0030229	very-low-density lipoprotein particle receptor activity	PMID:8626535^[1]	IDA: Inferred from Direct Assay		F
	GO:0034187	apolipoprotein E binding	PMID:8626535^[1]	IC: Inferred by Curator	GO:0030229	F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Kim DH et al. (1996) Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. J Biol Chem 271: 8373-80 PubMed GONUTS page
↑ ^2.0 ^2.1 Li X et al. (2003) Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain. Biochemistry 42: 10406-17 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Trommsdorff M et al. (1999) Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell 97: 689-701 PubMed GONUTS page
↑ Korporaal SJ et al. (2004) Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK. J Biol Chem 279: 52526-34 PubMed GONUTS page
↑ ^5.0 ^5.1 Riddell DR et al. (2001) Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane. J Lipid Res 42: 998-1002 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Korschineck I et al. (2001) Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue. J Biol Chem 276: 13192-7 PubMed GONUTS page

[PMID:8626535-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Kim DH et al. (1996) Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. J Biol Chem 271: 8373-80 PubMed GONUTS page

[PMID:12950167-1] 2.0 ^2.1 Li X et al. (2003) Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain. Biochemistry 42: 10406-17 PubMed GONUTS page

[PMID:10380922-2] 3.0 ^3.1 ^3.2 ^3.3 Trommsdorff M et al. (1999) Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell 97: 689-701 PubMed GONUTS page

[PMID:15459198-3] Korporaal SJ et al. (2004) Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK. J Biol Chem 279: 52526-34 PubMed GONUTS page

[PMID:11369809-4] 5.0 ^5.1 Riddell DR et al. (2001) Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane. J Lipid Res 42: 998-1002 PubMed GONUTS page

[PMID:11152697-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Korschineck I et al. (2001) Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue. J Biol Chem 276: 13192-7 PubMed GONUTS page

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HUMAN:LRP8

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