HUMAN:LAT

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	LAT
Protein Name(s)	Linker for activation of T-cells family member 1 36 kDa phospho-tyrosine adapter protein pp36 p36-38
External Links
EMBL	AF036906 AF036905 AJ223280 AC109460 BC011563
IPI	IPI00012888 IPI00218716
RefSeq	NP_001014987.1 NP_001014988.1 NP_001014989.2 NP_055202.1
UniGene	Hs.632179
ProteinModelPortal	O43561
DIP	DIP-29231N
IntAct	O43561
MINT	MINT-2836977
STRING	O43561
PhosphoSite	O43561
PRIDE	O43561
Ensembl	ENST00000360872
GeneID	27040
KEGG	hsa:27040
UCSC	uc002dsb.1 uc002dsd.1
CTD	27040
GeneCards	GC16P026864
HGNC	HGNC:18874
HPA	CAB002223 CAB012978 HPA011157
MIM	602354
neXtProt	NX_O43561
eggNOG	prNOG09295
GeneTree	ENSGT00390000014223
HOVERGEN	HBG018198
OMA	MESGEDY
PhylomeDB	O43561
Pathway_Interaction_DB	pi3kcipathway fcer1pathway tcrjnkpathway ptp1bpathway tcrpathway cd8tcrpathway
Reactome	REACT_604 REACT_6900
NextBio	49608
ArrayExpress	O43561
Bgee	O43561
CleanEx	HS_LAT
Genevestigator	O43561
GermOnline	ENSG00000169682
GO	GO:0001772 GO:0016021 GO:0005622 GO:0045121 GO:0005070 GO:0019722 GO:0007229 GO:0043303 GO:0030168 GO:0007265 GO:0050863 GO:0050852
InterPro	IPR008359
PRINTS	PR01781

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0001772	immunological synapse	PMID:12646565^[1]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005070	SH3/SH2 adaptor activity	PMID:9489702^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12186560^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P15498	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12646565^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P43403	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:14722116^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P19174	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:14722116^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q60631	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:16938345^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P06239	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:16938345^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P19174	F	Seeded From UniProt
	GO:0005622	intracellular	PMID:12646565^[1]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_12398	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_12421	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_12489	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_12498	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_12506	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_12525	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_12570	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_12604	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_12615	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_12618	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_23803	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0006955	immune response	PMID:15100278^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008359	P	Seeded From UniProt
	GO:0007229	integrin-mediated signaling pathway	PMID:15100278^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0007265	Ras protein signal transduction	PMID:12646565^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008359	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded From UniProt
	GO:0016021	integral to membrane	PMID:12646565^[1]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0019722	calcium-mediated signaling	PMID:12646565^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0019901	protein kinase binding	PMID:12186560^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q08881	F	Seeded From UniProt
	GO:0030168	platelet activation	Reactome:REACT_798	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0035556	intracellular signal transduction	PMID:12646565^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0042110	T cell activation	PMID:12186560^[3]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0043303	mast cell degranulation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0467	P	Seeded From UniProt
	GO:0045121	membrane raft	PMID:14722116^[4]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0050852	T cell receptor signaling pathway	Reactome:REACT_12526	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:21966541^[7]	IMP: Inferred from Mutant Phenotype		P	Figure 2	complete
	GO:0050863	regulation of T cell activation	PMID:12646565^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045860	positive regulation of protein kinase activity	PMID:14624253^[8]	IEP: Inferred from Expression Pattern		P	Figure 1, 2BC, and Fig. 3C-E. Figure 3 in particular indicates that "proper localization and signaling through the adapter LAT are required for normal suppression of RAG gene expression".	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Hartgroves LC et al. (2003) Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains. J Biol Chem 278: 20389-94 PubMed GONUTS page
↑ Zhang W et al. (1998) LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92: 83-92 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Perez-Villar JJ et al. (2002) Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. Biochemistry 41: 10732-40 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Koonpaew S et al. (2004) The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. J Biol Chem 279: 11229-35 PubMed GONUTS page
↑ ^5.0 ^5.1 Jiang Y & Cheng H (2007) Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes. Leuk Res 31: 541-5 PubMed GONUTS page
↑ ^6.0 ^6.1 Goda S et al. (2004) Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein. J Immunol 172: 5379-87 PubMed GONUTS page
↑ Markegard E et al. (2011) Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. PLoS One 6: e25540 PubMed GONUTS page
↑ Roose JP et al. (2003) T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol 1: E53 PubMed GONUTS page

[PMID:12646565-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Hartgroves LC et al. (2003) Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains. J Biol Chem 278: 20389-94 PubMed GONUTS page

[PMID:9489702-1] Zhang W et al. (1998) LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92: 83-92 PubMed GONUTS page

[PMID:12186560-2] 3.0 ^3.1 ^3.2 Perez-Villar JJ et al. (2002) Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. Biochemistry 41: 10732-40 PubMed GONUTS page

[PMID:14722116-3] 4.0 ^4.1 ^4.2 Koonpaew S et al. (2004) The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. J Biol Chem 279: 11229-35 PubMed GONUTS page

[PMID:16938345-4] 5.0 ^5.1 Jiang Y & Cheng H (2007) Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes. Leuk Res 31: 541-5 PubMed GONUTS page

[PMID:15100278-5] 6.0 ^6.1 Goda S et al. (2004) Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein. J Immunol 172: 5379-87 PubMed GONUTS page

[PMID:21966541-6] Markegard E et al. (2011) Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. PLoS One 6: e25540 PubMed GONUTS page

[PMID:14624253-7] Roose JP et al. (2003) T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol 1: E53 PubMed GONUTS page

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HUMAN:LAT

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