HUMAN:KSYK

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	SYK
Protein Name(s)	Tyrosine-protein kinase SYK Spleen tyrosine kinase
External Links
EMBL	Z29630 L28824 AL354862 BC001645 BC011399 BC002962 X73568
IPI	IPI00018597 IPI00218278
PIR	A53596
RefSeq	NP_001128524.1 NP_001167638.1 NP_001167639.1 NP_003168.2
UniGene	Hs.371720
PDB	1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV
PDBsum	1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV
ProteinModelPortal	P43405
SMR	P43405
DIP	DIP-253N
IntAct	P43405
MINT	MINT-148486
STRING	P43405
PhosphoSite	P43405
PeptideAtlas	P43405
PRIDE	P43405
Ensembl	ENST00000375746 ENST00000375754
GeneID	6850
KEGG	hsa:6850
UCSC	uc004aqz.1
CTD	6850
GeneCards	GC09P063244
H-InvDB	HIX0008158
HGNC	HGNC:11491
HPA	CAB007773 HPA001384
MIM	600085
neXtProt	NX_P43405
eggNOG	prNOG06189
HOGENOM	HBG714705
HOVERGEN	HBG001540
InParanoid	P43405
OMA	HYSYKAD
OrthoDB	EOG4WSW93
PhylomeDB	P43405
BRENDA	2.7.10.2
Pathway_Interaction_DB	alphasynuclein_pathway nfkappabatypicalpathway bcr_5pathway pi3kcipathway fcer1pathway il2_1pathway avb3_opn_pathway txa2pathway
Reactome	REACT_111102 REACT_604 REACT_6900
BindingDB	P43405
NextBio	26739
ArrayExpress	P43405
Bgee	P43405
CleanEx	HS_SYK
Genevestigator	P43405
GermOnline	ENSG00000165025
GO	GO:0005829 GO:0042101 GO:0005524 GO:0005178 GO:0004715 GO:0008283 GO:0007229 GO:0044419 GO:0007159 GO:0030593 GO:0009887 GO:0030168 GO:0006461
InterPro	IPR011009 IPR023420 IPR000719 IPR017441 IPR001245 IPR000980 IPR008266 IPR020635 IPR020757 IPR012234
Gene3D	G3DSA:1.10.930.10 G3DSA:3.30.505.10
KO	K05855
PANTHER	PTHR24418:SF99
Pfam	PF07714 PF00017
PIRSF	PIRSF000604
PRINTS	PR00401 PR00109
SMART	SM00252 SM00219
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00109 PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded From UniProt
	GO:0000187	activation of MAPK activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0001820	serotonin secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000016942	F	Seeded From UniProt
	GO:0004672	protein kinase activity	PMID:12885943^[1]	NAS: Non-traceable Author Statement		F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020635	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0829	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	PMID:8163536^[2]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012234	F	Seeded From UniProt
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020757	F	Seeded From UniProt
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR023420	F	Seeded From UniProt
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.10.2	F	Seeded From UniProt
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	F	Seeded From UniProt
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Reactome:REACT_23793	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Reactome:REACT_23800	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0004716	receptor signaling protein tyrosine kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	F	Seeded From UniProt
	GO:0005178	integrin binding	PMID:12885943^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P05107	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:8627166^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P20273	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012234	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020757	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	F	Seeded From UniProt
	GO:0005622	intracellular	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012234	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020757	C	Seeded From UniProt
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_20638	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_20675	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_2221	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_23764	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_23775	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_23793	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_23800	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_23803	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_23931	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_27233	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_27313	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_23775	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_27233	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0006461	protein complex assembly	PMID:8163536^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012234	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020757	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	PMID:12885943^[1]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0006468	protein phosphorylation	PMID:8163536^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007159	leukocyte cell-cell adhesion	PMID:12885943^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0007166	cell surface receptor linked signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0007167	enzyme linked receptor protein signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0007229	integrin-mediated signaling pathway	PMID:12885943^[1]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0007257	activation of JUN kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0008283	cell proliferation	PMID:10963601^[4]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0009887	organ morphogenesis	PMID:7477352^[5]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded From UniProt
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded From UniProt
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	Seeded From UniProt
	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0019370	leukotriene biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0019815	B cell receptor complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	C	Seeded From UniProt
	GO:0019904	protein domain specific binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000016942	F	Seeded From UniProt
	GO:0030168	platelet activation	Reactome:REACT_798	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0030593	neutrophil chemotaxis	PMID:12885943^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0035556	intracellular signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012234	P	Seeded From UniProt
	GO:0035556	intracellular signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020757	P	Seeded From UniProt
	GO:0035556	intracellular signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0042101	T cell receptor complex	PMID:8176201^[6]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0043306	positive regulation of mast cell degranulation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0043306	positive regulation of mast cell degranulation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000016942	P	Seeded From UniProt
	GO:0043366	beta selection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P	Seeded From UniProt
	GO:0045401	positive regulation of interleukin-3 biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0045579	positive regulation of B cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0045588	positive regulation of gamma-delta T cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0046638	positive regulation of alpha-beta T cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0046641	positive regulation of alpha-beta T cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020757	P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000016942	P	Seeded From UniProt
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0050776	regulation of immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000016942	P	Seeded From UniProt
	GO:0050850	positive regulation of calcium-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0050853	B cell receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113852	P	Seeded From UniProt
	GO:0008283	cell proliferation	PMID:10963601^[4]	IDA: Inferred from Direct Assay		P	figure 1 C c, Immunoprecipitation (IP) and western blot (WB) detection of Syk protein using polyclonal (LR) and monoclonal (4D10) antibodies detecting Syk expression in human breast cancer cell lines. Figure 2 Syk expression in normal and pathological human breast tissue samples.	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Willeke T et al. (2003) A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils. J Leukoc Biol 74: 260-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Law CL et al. (1994) Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. J Biol Chem 269: 12310-9 PubMed GONUTS page
↑ Law CL et al. (1996) CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. J Exp Med 183: 547-60 PubMed GONUTS page
↑ ^4.0 ^4.1 Coopman PJ et al. (2000) The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature 406: 742-7 PubMed GONUTS page
↑ Turner M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378: 298-302 PubMed GONUTS page
↑ Chan AC et al. (1994) Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol 152: 4758-66 PubMed GONUTS page

[PMID:12885943-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Willeke T et al. (2003) A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils. J Leukoc Biol 74: 260-9 PubMed GONUTS page

[PMID:8163536-1] 2.0 ^2.1 ^2.2 Law CL et al. (1994) Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. J Biol Chem 269: 12310-9 PubMed GONUTS page

[PMID:8627166-2] Law CL et al. (1996) CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. J Exp Med 183: 547-60 PubMed GONUTS page

[PMID:10963601-3] 4.0 ^4.1 Coopman PJ et al. (2000) The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature 406: 742-7 PubMed GONUTS page

[PMID:7477352-4] Turner M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378: 298-302 PubMed GONUTS page

[PMID:8176201-5] Chan AC et al. (1994) Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol 152: 4758-66 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

HUMAN:KSYK

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References

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