HUMAN:KPCZ

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	PRKCZ ( synonyms: PKC2 )
Protein Name(s)	Protein kinase C zeta type nPKC-zeta
External Links
UniProt Identifier	KPCZ_HUMAN
UniProt Accessions	Q05513, A8K4N0, Q15207, Q5SYT5, Q969S4,
EMBL	L14283, BT007082, AK290995, AL391845, AL590822, AL645703, AL645703, AL391845, AL590822, BC008058, BC014270, Z15108,
PIR	JN0877,
RefSeq	NP_001028753.1, NP_001028754.1, NP_002735.3,
IntAct	Q05513,
Ensembl	ENST00000378567,
Pfam	PF00130, PF00564, PF00069, PF00433,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005768	endosome		IEA		C	Source: UniProtKB-KW
	GO:0005624	membrane fraction		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0005886	plasma membrane		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0005524	ATP binding		IEA		F	Source: InterPro
	GO:0004700	atypical protein kinase C activity		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0019992	diacylglycerol binding		IEA		F	Source: UniProtKB-KW
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0008270	zinc ion binding		IEA		F	Source: InterPro
	GO:0006916	anti-apoptosis		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0007242	intracellular signaling cascade		IEA		P	Source: InterPro
	GO:0006468	protein amino acid phosphorylation		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	P
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004672	protein kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000961	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012233	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017892	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0004674	protein serine/threonine kinase activity	PMID:15069075^[1]	IDA: Inferred from Direct Assay		F
	GO:0004697	protein kinase C activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.11.13	F
	GO:0005515	protein binding	PMID:11260256^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BYG5	F
	GO:0005515	protein binding	PMID:11755531^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P37198	F
	GO:0005515	protein binding	PMID:12893243^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O75689	F
	GO:0005515	protein binding	PMID:15707389^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P14314	F
	GO:0005515	protein binding	PMID:17588663^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q04759	F
	GO:0005515	protein binding	PMID:18190796^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IX03	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000961	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012233	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017892	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005624	membrane fraction	PMID:7925449^[8]	TAS: Traceable Author Statement		C
	GO:0005625	soluble fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	C
	GO:0005635	nuclear envelope	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:7925449^[8]	TAS: Traceable Author Statement		C
	GO:0005768	endosome	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0967	C
	GO:0005768	endosome	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0101	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	C
	GO:0005886	plasma membrane	PMID:7925449^[8]	TAS: Traceable Author Statement		C
	GO:0005911	cell-cell junction	PMID:20332120^[9]	IDA: Inferred from Direct Assay		C
	GO:0005923	tight junction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	C
	GO:0005938	cell cortex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000961	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017892	P
	GO:0006468	protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	P
	GO:0006916	anti-apoptosis	PMID:10770953^[10]	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	PMID:8224878^[11]	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012233	F
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016363	nuclear matrix	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	C
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0018105	peptidyl-serine phosphorylation	PMID:15069075^[1]	IDA: Inferred from Direct Assay		P
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C
	GO:0030054	cell junction	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0038	C
	GO:0030168	platelet activation	Reactome:REACT_798	TAS: Traceable Author Statement		P
	GO:0031333	negative regulation of protein complex assembly	PMID:15069075^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0035556	intracellular signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002219	P
	GO:0043234	protein complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	C
	GO:0043560	insulin receptor substrate binding	PMID:15069075^[1]	IC: Inferred by Curator	GO:0018105	F
	GO:0045179	apical cortex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000030922	C
	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:15069075^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	PMID:15069075^[1]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Moeschel K et al. (2004) Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. J Biol Chem 279: 25157-63 PubMed GONUTS page
↑ Noda Y et al. (2001) Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. Genes Cells 6: 107-19 PubMed GONUTS page
↑ Chang S et al. (2002) p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition. FEBS Lett 510: 57-61 PubMed GONUTS page
↑ Zemlickova E et al. (2003) Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C. Biochem Biophys Res Commun 307: 459-65 PubMed GONUTS page
↑ Hodgkinson CP et al. (2005) Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. Biochem J 388: 785-93 PubMed GONUTS page
↑ Gruber T et al. (2008) PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes. Mol Immunol 45: 117-26 PubMed GONUTS page
↑ Hilton HN et al. (2008) KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. Biochim Biophys Acta 1783: 383-93 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Tippmer S et al. (1994) Bradykinin induces translocation of the protein kinase C isoforms alpha, epsilon, and zeta. Eur J Biochem 225: 297-304 PubMed GONUTS page
↑ Lampugnani MG et al. (2010) CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci 123: 1073-80 PubMed GONUTS page
↑ Rust C et al. (2000) The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J Biol Chem 275: 20210-6 PubMed GONUTS page
↑ Barbee JL et al. (1993) The cDNA sequence encoding human protein kinase C-zeta. Gene 132: 305-6 PubMed GONUTS page

[PMID:15069075-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Moeschel K et al. (2004) Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. J Biol Chem 279: 25157-63 PubMed GONUTS page

[PMID:11260256-1] Noda Y et al. (2001) Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. Genes Cells 6: 107-19 PubMed GONUTS page

[PMID:11755531-2] Chang S et al. (2002) p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition. FEBS Lett 510: 57-61 PubMed GONUTS page

[PMID:12893243-3] Zemlickova E et al. (2003) Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C. Biochem Biophys Res Commun 307: 459-65 PubMed GONUTS page

[PMID:15707389-4] Hodgkinson CP et al. (2005) Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. Biochem J 388: 785-93 PubMed GONUTS page

[PMID:17588663-5] Gruber T et al. (2008) PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes. Mol Immunol 45: 117-26 PubMed GONUTS page

[PMID:18190796-6] Hilton HN et al. (2008) KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. Biochim Biophys Acta 1783: 383-93 PubMed GONUTS page

[PMID:7925449-7] 8.0 ^8.1 ^8.2 Tippmer S et al. (1994) Bradykinin induces translocation of the protein kinase C isoforms alpha, epsilon, and zeta. Eur J Biochem 225: 297-304 PubMed GONUTS page

[PMID:20332120-8] Lampugnani MG et al. (2010) CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci 123: 1073-80 PubMed GONUTS page

[PMID:10770953-9] Rust C et al. (2000) The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J Biol Chem 275: 20210-6 PubMed GONUTS page

[PMID:8224878-10] Barbee JL et al. (1993) The cDNA sequence encoding human protein kinase C-zeta. Gene 132: 305-6 PubMed GONUTS page

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HUMAN:KPCZ

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