HUMAN:KPCD2

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	PRKD2 ( synonyms: PKD2 )
Protein Name(s)	Serine/threonine-protein kinase D2 nPKC-D2
External Links
UniProt Identifier	KPCD2_HUMAN
UniProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8,
EMBL	AF309082, AC008635, AC093503, AL050147, AF151021,
PIR	T08777,
RefSeq	NP_001073349.1, NP_001073350.1, NP_001073351.1, NP_057541.2,
PDB	2COA, 3BGM,
Ensembl	ENST00000291281, ENST00000433867, ENST00000454760,
Pfam	PF00130, PF00169, PF00069,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0016020	membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005524	ATP binding		NAS: Non-traceable Author Statement		F	Source: UniProtKB
	GO:0046872	metal ion binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0004697	protein kinase C activity		IEA: Inferred from Electronic Annotation		F	Source: EC
	GO:0023034	intracellular signaling pathway		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0006468	protein phosphorylation		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0019976	interleukin-2 binding	PMID:17077180^[1]	IDA: Inferred from Direct Assay		F	Figure (4) IL-2 promoter activation upon TCR stimulation in Jurkat cells introduced with WT-PKD2 gene using a lentiviral system.	complete
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:17077180^[1]	IDA: Inferred from Direct Assay		P	Figure (4) IL-2 promoter activation (which leads to positive regulation of transcription)	complete
	GO:0046777	protein autophosphorylation	PMID:17077180^[1]	IDA: Inferred from Direct Assay		P	Figure (3) Endogenous PKD2 immunoprecipitated from the cell lysates using anti-PKCµ antibody was subjected to in vitro kinase assay to detect autophosphorylation of PKD2 in the presence or absence of the 3 µM of the indicated inhibitors.	complete
	GO:0033674	positive regulation of kinase activity	PMID:17077180^[1]	IDA: Inferred from Direct Assay		P	Figure (3) Endogenous PKD2 kinase activity is up-regulated with TCR stimulation in a ZAP-70-independent manner.	complete
	GO:0008219	cell death	PMID:17077180^[1]	IDA: Inferred from Direct Assay		P	Figure (5) CA-PKD2 expression induced cell death after TCR stimulation. Jurkat cells expressing WT-PKD2-GFP and CA-PKD2-GFP together with uninfected Jurkat cells were stimulated with anti-CD3 mAb. (A) After stimulation at the indicated time, cells were recovered, stained with propidium iodide and subjected to FACS analyses to estimate the proportion of the dead cells. Open and closed symbols represent the percentages of dead cells in the unstimulated or anti-CD3 mAb-stimulated cells, respectively.	complete
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004672	protein kinase activity	PMID:17077180^[1]	IDA: Inferred from Direct Assay		F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0006468	protein phosphorylation	PMID:22228765^[2]	IDA: Inferred from Direct Assay		P	Figure 1	complete
	GO:0004674	protein serine/threonine kinase activity	PMID:11062248^[3]	NAS: Non-traceable Author Statement		F
	GO:0005794	Golgi apparatus	PMID:11239398^[4]	IDA: Inferred from Direct Assay		C	Figure 1, D.	complete
	GO:0004674	protein serine/threonine kinase activity	PMID:18440775^[5]	IDA: Inferred from Direct Assay		F
	GO:0004697	protein kinase C activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015727	F
	GO:0004697	protein kinase C activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.11.13	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015727	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005524	ATP binding	GO_REF:0000029	NAS: Non-traceable Author Statement		F
	GO:0005622	intracellular	GO_REF:0000029	NAS: Non-traceable Author Statement		C
	GO:0005634	nucleus	PMID:17077180^[1]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:17077180^[1]	IDA: Inferred from Direct Assay		C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015727	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0006468	protein phosphorylation	GO_REF:0000029	NAS: Non-traceable Author Statement		P
	GO:0006468	protein phosphorylation	PMID:11062248^[3]	NAS: Non-traceable Author Statement		P
	GO:0008219	cell death	PMID:17077180^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0018105	peptidyl-serine phosphorylation	PMID:18440775^[5]	IDA: Inferred from Direct Assay		P
	GO:0035556	intracellular signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002219	P
	GO:0035556	intracellular signal transduction	GO_REF:0000029	NAS: Non-traceable Author Statement		P
	GO:0035767	endothelial cell chemotaxis	PMID:18440775^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:18440775^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0045766	positive regulation of angiogenesis	PMID:18440775^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:17077180^[1]	IDA: Inferred from Direct Assay		P
	GO:0046777	protein autophosphorylation	PMID:17077180^[1]	IDA: Inferred from Direct Assay		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:18440775^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0050852	T cell receptor signaling pathway	PMID:17077180^[1]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Irie A et al. (2006) Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells. Int Immunol 18: 1737-47 PubMed GONUTS page
↑ Pusapati GV et al. (2012) Protein kinase D regulates RhoA activity via rhotekin phosphorylation. J Biol Chem 287: 9473-83 PubMed GONUTS page
↑ ^3.0 ^3.1 Sturany S et al. (2001) Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases. J Biol Chem 276: 3310-8 PubMed GONUTS page
↑ Liljedahl M et al. (2001) Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network. Cell 104: 409-20 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Evans IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell Signal 20: 1375-84 PubMed GONUTS page

[PMID:17077180-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Irie A et al. (2006) Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells. Int Immunol 18: 1737-47 PubMed GONUTS page

[PMID:22228765-1] Pusapati GV et al. (2012) Protein kinase D regulates RhoA activity via rhotekin phosphorylation. J Biol Chem 287: 9473-83 PubMed GONUTS page

[PMID:11062248-2] 3.0 ^3.1 Sturany S et al. (2001) Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases. J Biol Chem 276: 3310-8 PubMed GONUTS page

[PMID:11239398-3] Liljedahl M et al. (2001) Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network. Cell 104: 409-20 PubMed GONUTS page

[PMID:18440775-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Evans IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell Signal 20: 1375-84 PubMed GONUTS page

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HUMAN:KPCD2

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