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HUMAN:KMT2C

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KMT2C (synonyms: HALR, KIAA1506, MLL3)
Protein Name(s) Histone-lysine N-methyltransferase 2C

Lysine N-methyltransferase 2C Homologous to ALR protein Myeloid/lymphoid or mixed-lineage leukemia protein 3

External Links
UniProt Q8NEZ4
EMBL AY024361
AF264750
AC006017
AC104692
AC005631
AB040939
AK022687
AK075113
AL833924
CCDS CCDS5931.1
RefSeq NP_733751.2
UniGene Hs.647120
PDB 2YSM
2YUK
3UVL
4ERY
PDBsum 2YSM
2YUK
3UVL
4ERY
ProteinModelPortal Q8NEZ4
SMR Q8NEZ4
BioGrid 121835
DIP DIP-48649N
IntAct Q8NEZ4
MINT MINT-3042700
STRING 9606.ENSP00000262189
BindingDB Q8NEZ4
ChEMBL CHEMBL2189113
iPTMnet Q8NEZ4
PhosphoSite Q8NEZ4
BioMuta KMT2C
DMDM 221222521
MaxQB Q8NEZ4
PaxDb Q8NEZ4
PRIDE Q8NEZ4
Ensembl ENST00000262189
ENST00000355193
GeneID 58508
KEGG hsa:58508
UCSC uc003wkz.3
uc003wla.3
CTD 58508
GeneCards KMT2C
H-InvDB HIX0007238
HIX0016202
HIX0080234
HGNC HGNC:13726
MIM 606833
neXtProt NX_Q8NEZ4
PharmGKB PA30847
eggNOG KOG4443
COG2940
GeneTree ENSGT00760000119228
HOVERGEN HBG045586
InParanoid Q8NEZ4
KO K09188
OMA MPSLPGW
PhylomeDB Q8NEZ4
TreeFam TF354317
Reactome R-HSA-3214841
EvolutionaryTrace Q8NEZ4
GeneWiki MLL3
GenomeRNAi 58508
NextBio 65023
PRO PR:Q8NEZ4
Proteomes UP000005640
Bgee Q8NEZ4
CleanEx HS_MLL3
ExpressionAtlas Q8NEZ4
Genevisible Q8NEZ4
GO GO:0035097
GO:0005654
GO:0005634
GO:0003677
GO:0042800
GO:0044822
GO:0008270
GO:0006325
GO:0061029
GO:0051568
GO:0035556
GO:0035264
GO:0048146
GO:0006355
GO:0007338
GO:0006351
Gene3D 3.30.40.10
InterPro IPR017956
IPR003889
IPR003888
IPR009071
IPR000637
IPR002219
IPR003616
IPR001214
IPR001594
IPR011011
IPR001965
IPR019787
IPR001841
IPR013083
Pfam PF05965
PF05964
PF00628
PF00856
SMART SM00384
SM00109
SM00542
SM00541
SM00398
SM00249
SM00508
SM00184
SM00317
SUPFAM SSF47095
SSF57903
PROSITE PS51543
PS51542
PS00354
PS50868
PS50280
PS50216
PS01359
PS50016
PS50089

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0044666

MLL3/4 complex

PMID:17500065[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0263667
PANTHER:PTN002505160
UniProtKB:O14686

P

Seeded From UniProt

complete

part_of

GO:0044666

MLL3/4 complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023518
FB:FBgn0263667
PANTHER:PTN002505160
UniProtKB:O14686
UniProtKB:Q8NEZ4
WB:WBGene00011729

C

Seeded From UniProt

complete

GO:0097692

histone H3-K4 monomethylation

PMID:26324722[4]

ECO:0000314

P

Figure 1B

complete
CACAO 11229

enables

GO:0042800

histone methyltransferase activity (H3-K4 specific)

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023518
PANTHER:PTN002505160
UniProtKB:Q8NEZ4
WB:WBGene00011729

F

Seeded From UniProt

complete

enables

GO:0042393

histone binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0263667
PANTHER:PTN002505160

F

Seeded From UniProt

complete

enables

GO:0003713

transcription coactivator activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023518
PANTHER:PTN002505160

F

Seeded From UniProt

complete

enables

GO:0042800

histone methyltransferase activity (H3-K4 specific)

PMID:17500065[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0035097

histone methyltransferase complex

PMID:17500065[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17500065[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0034968

histone lysine methylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0018024

P

Seeded From UniProt

complete

involved_in

GO:0051568

histone H3-K4 methylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0042800

P

Seeded From UniProt

complete

involved_in

GO:0051568

histone H3-K4 methylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0042800

P

Seeded From UniProt

complete

involved_in

GO:0051568

histone H3-K4 methylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0042800

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003888
InterPro:IPR003889

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000637

P

Seeded From UniProt

complete

enables

GO:0042800

histone methyltransferase activity (H3-K4 specific)

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037877

F

Seeded From UniProt

complete

part_of

GO:0044666

MLL3/4 complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037877

C

Seeded From UniProt

complete

enables

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.1.43

F

Seeded From UniProt

complete

involved_in

GO:0045652

regulation of megakaryocyte differentiation

Reactome:R-HSA-8936459

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8937050
Reactome:R-HSA-8937037
Reactome:R-HSA-8937016
Reactome:R-HSA-8936979
Reactome:R-HSA-8936621
Reactome:R-HSA-8936616
Reactome:R-HSA-8936481
Reactome:R-HSA-8935740
Reactome:R-HSA-5637686
Reactome:R-HSA-5244692
Reactome:R-HSA-5159245

ECO:0000304

author statement supported by traceable reference used in manual assertion











C

Seeded From UniProt

complete

enables

GO:0016746

transferase activity, transferring acyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0012

F

Seeded From UniProt

complete

enables

GO:0008168

methyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page
  2. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Shinsky, SA & Cosgrove, MS (2015) Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex. J. Biol. Chem. 290 25819-33 PubMed GONUTS page
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