HUMAN:KLF5

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	KLF5 ( synonyms: BTEB2, CKLF, IKLF )
Protein Name(s)	Krueppel-like factor 5 Basic transcription element-binding protein 2 BTE-binding protein 2 Colon krueppel-like factor GC-box-binding protein 2 Intestinal-enriched krueppel-like factor Transcription factor BTEB2
External Links
UniProt Identifier	KLF5_HUMAN
UniProt Accessions	Q13887, Q9UHP8,
EMBL	AF132818, AB030824, AF287272, BC007695, BC042131, D14520,
PIR	S35643,
RefSeq	NP_001721.2,
PDB	2EBT,
Ensembl	ENST00000377687,
Pfam	PF00096,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0001525	angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005279	P
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013087	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005279	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005279	F
	GO:0003702	RNA polymerase II transcription factor activity	PMID:8479902^[1]	TAS: Traceable Author Statement		F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007087	C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015880	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005279	P
	GO:0006366	transcription from RNA polymerase II promoter	PMID:8479902^[1]	TAS: Traceable Author Statement		P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007087	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015880	F
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000054653	P
	GO:0030033	microvillus assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005279	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	PMID:21487105^[2]	IDA: Inferred from Direct Assay		P	Figure 3 details a number of experiments involving the expression and activity of FOXO1. Figure 3A shows that the presence of the KLF5 gene product, provided on a plasmid vector, is required for any expression of FOXO1 above baseline as measured by RNA pol II production of luciferase expressed in tandem with the FOXO1 gene in human cell culture.	complete
	GO:0001525	angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005279	P
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013087	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005279	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005279	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007087	C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015880	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005279	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005279	P
	GO:0006366	transcription from RNA polymerase II promoter	PMID:8479902^[1]	TAS: Traceable Author Statement		P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007087	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015880	F
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000054653	P
	GO:0030033	microvillus assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005279	P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005279	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Sogawa K et al. (1993) cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. Nucleic Acids Res 21: 1527-32 PubMed GONUTS page
↑ Nakajima Y et al. (2011) Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5. Sci Signal 4: ra22 PubMed GONUTS page

[PMID:8479902-0] 1.0 ^1.1 ^1.2 Sogawa K et al. (1993) cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. Nucleic Acids Res 21: 1527-32 PubMed GONUTS page

[PMID:21487105-1] Nakajima Y et al. (2011) Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5. Sci Signal 4: ra22 PubMed GONUTS page

[1]

[2]

HUMAN:KLF5

Contents

Annotations

Notes

References

a

d

i

m

n

n cont.

p

r

s

t

z

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox