HUMAN:KIFA3

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	KIFAP3 ( synonyms: KIF3AP, SMAP )
Protein Name(s)	Kinesin-associated protein 3 KAP-3 KAP3 Smg GDS-associated protein
External Links
UniProt Identifier	KIFA3_HUMAN
UniProt Accessions	Q92845, B2RDL1, Q8NHU7, Q9H416,
EMBL	U59919, AK315586, AL121714, AL356475, AL356475, AL121714, CH471067, BC028679,
RefSeq	NP_001191443.1, NP_001191445.1, NP_001191446.1, NP_055785.2,
IntAct	Q92845,
Ensembl	ENST00000361580,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005783	endoplasmic reticulum		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0016939	kinesin II complex		ISS: Inferred from Sequence or Structural Similarity		C	Source: UniProtKB
	GO:0019894	kinesin binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0007017	microtubule-based process		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0005876	spindle microtubule	PMID:16298999^[1]	IDA: Inferred from Direct Assay		C	Immunoblotting during metaphase shows KAP3 at microtubules	complete
	GO:0007165	signal transduction		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0005813	centrosome	PMID:16298999^[1]	IDA: Inferred from Direct Assay		C	Immunoblotting during cell cycle show KAP3 at centosomes during interphase fig 4	complete
	GO:0042301	phosphate binding	PMID:16298999^[1]	IDA: Inferred from Direct Assay		F	Figure 1 shows larger molecule in presence in mitotic cells, which are reduced by BAP but not in presence of phosphatatse inhibitors	complete
	GO:0005515	protein binding	PMID:16298999^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y496	F	Figure 2 shows immunopptation of KIF3a/3b complex with KAP3 and fig 3 shows separate immunoppt of kif3a	complete
	GO:0008022	protein C-terminus binding	PMID:16298999^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y496	F	Fig 3a shows failed immunoppt with mutant lacking c terminus of KIF3a, also inferred from mutant phenotype Species confirmed in PMID11912492	complete
	GO:0005515	protein binding	PMID:16298999^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NQT8	F	Figure 2 shows immunopptation of KIF3a/3b complex with KAP3 and fig 3 shows separate immunoppt of kif3b	complete
	GO:0008022	protein C-terminus binding	PMID:16298999^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NQT8	F	Fig 3a shows failed immunoppt with mutant lacking c terminus of KIF3b, also inferred from mutant phenotype Species confirmed in PMID11912492	complete
	GO:0006461	protein complex assembly		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0000794	condensed nuclear chromosome	PMID:16298999^[1]	IDA: Inferred from Direct Assay		C
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011989	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016024	F
	GO:0005515	protein binding	PMID:9506951^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UQE7	F
	GO:0005783	endoplasmic reticulum	PMID:8900189^[3]	TAS: Traceable Author Statement		C
	GO:0005813	centrosome	PMID:16298999^[1]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	Reactome:REACT_24947	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_25309	TAS: Traceable Author Statement		C
	GO:0005871	kinesin complex	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008658	C
	GO:0005876	spindle microtubule	PMID:16298999^[1]	IDA: Inferred from Direct Assay		C
	GO:0006461	protein complex assembly	PMID:8900189^[3]	TAS: Traceable Author Statement		P
	GO:0007017	microtubule-based process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000076830	P
	GO:0007017	microtubule-based process	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P70188	P
	GO:0007018	microtubule-based movement	Reactome:REACT_25201	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	PMID:8900189^[3]	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0008104	protein localization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000076830	P
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000076830	P
	GO:0016939	kinesin II complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000076830	C
	GO:0016939	kinesin II complex	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P70188	C
	GO:0016939	kinesin II complex	PMID:16298999^[1]	IDA: Inferred from Direct Assay		C
	GO:0019894	kinesin binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008658	F
	GO:0019894	kinesin binding	PMID:16298999^[1]	IPI: Inferred from Physical Interaction	UniProtKB:O15066	F
	GO:0019894	kinesin binding	PMID:16298999^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y496	F
	GO:0046587	positive regulation of calcium-dependent cell-cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000076830	P
	GO:0072383	plus-end-directed vesicle transport along microtubule	PMID:16298999^[1]	TAS: Traceable Author Statement		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Haraguchi K et al. (2006) Role of the kinesin-2 family protein, KIF3, during mitosis. J Biol Chem 281: 4094-9 PubMed GONUTS page
↑ Shimizu K et al. (1998) Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. J Biol Chem 273: 6591-4 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Shimizu K et al. (1996) SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase. J Biol Chem 271: 27013-7 PubMed GONUTS page

[PMID:16298999-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Haraguchi K et al. (2006) Role of the kinesin-2 family protein, KIF3, during mitosis. J Biol Chem 281: 4094-9 PubMed GONUTS page

[PMID:9506951-1] Shimizu K et al. (1998) Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. J Biol Chem 273: 6591-4 PubMed GONUTS page

[PMID:8900189-2] 3.0 ^3.1 ^3.2 Shimizu K et al. (1996) SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase. J Biol Chem 271: 27013-7 PubMed GONUTS page

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HUMAN:KIFA3

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