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HUMAN:KCC4
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | CAMK4 (synonyms: CAMK, CAMK-GR, CAMKIV) | |
| Protein Name(s) | Calcium/calmodulin-dependent protein kinase type IV
CaMK IV CaM kinase-GR | |
| External Links | ||
| EMBL | D30742 L17000 L24959 CH471086 CH471086 BC016695 BC025687 | |
| IPI | IPI00430411 | |
| PIR | A53036 | |
| RefSeq | NP_001735.1 | |
| UniGene | Hs.591269 | |
| PDB | 2W4O | |
| PDBsum | 2W4O | |
| ProteinModelPortal | Q16566 | |
| SMR | Q16566 | |
| STRING | Q16566 | |
| PhosphoSite | Q16566 | |
| PeptideAtlas | Q16566 | |
| PRIDE | Q16566 | |
| Ensembl | ENST00000282356 | |
| GeneID | 814 | |
| KEGG | hsa:814 | |
| UCSC | uc003kpf.1 | |
| CTD | 814 | |
| GeneCards | GC05P105739 | |
| H-InvDB | HIX0005080 | |
| HGNC | HGNC:1464 | |
| HPA | CAB004347 HPA011753 HPA017206 | |
| MIM | 114080 | |
| neXtProt | NX_Q16566 | |
| PharmGKB | PA26050 | |
| eggNOG | prNOG13858 | |
| GeneTree | ENSGT00550000074354 | |
| HOGENOM | HBG755340 | |
| HOVERGEN | HBG108055 | |
| InParanoid | Q16566 | |
| OMA | TVPSCSA | |
| PhylomeDB | Q16566 | |
| BRENDA | 2.7.11.17 | |
| Pathway_Interaction_DB | nfat_3pathway hdac_classii_pathway pi3kplctrkpathway | |
| Reactome | REACT_111102 REACT_13685 | |
| NextBio | 3300 | |
| PMAP-CutDB | Q16566 | |
| ArrayExpress | Q16566 | |
| Bgee | Q16566 | |
| CleanEx | HS_CAMK4 | |
| Genevestigator | Q16566 | |
| GermOnline | ENSG00000152495 | |
| GO | GO:0005829 GO:0005654 GO:0005524 GO:0005516 GO:0004683 GO:0007202 GO:0006954 GO:0007616 GO:0043011 GO:0048011 GO:0045893 GO:0045670 GO:0033081 GO:0007268 | |
| InterPro | IPR011009 IPR000719 IPR017441 IPR017442 IPR008271 IPR002290 | |
| KO | K05869 | |
| Pfam | PF00069 | |
| SMART | SM00220 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004683 |
calmodulin-dependent protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005516 |
calmodulin binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_15320 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_15332 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_15427 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_20666 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
Reactome:REACT_15332 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005829 |
cytosol |
Reactome:REACT_15339 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006954 |
inflammatory response |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007165 |
signal transduction |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007202 |
activation of phospholipase C activity |
Reactome:REACT_12079 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0007268 |
synaptic transmission |
Reactome:REACT_13477 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0007268 |
synaptic transmission |
Reactome:REACT_13685 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0007616 |
long-term memory |
IGI: Inferred from Genetic Interaction |
|
P |
Seeded From UniProt |
|||
| GO:0016301 |
kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016310 |
phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0033081 |
regulation of T cell differentiation in thymus |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0043011 |
myeloid dendritic cell differentiation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045670 |
regulation of osteoclast differentiation |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0048011 |
nerve growth factor receptor signaling pathway |
Reactome:REACT_11061 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0002372 |
myeloid dendritic cell cytokine production |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0004683 |
IDA: Inferred from Direct Assay |
Figure 2 |
complete | |||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kitani T et al. (1994) cDNA cloning and expression of human calmodulin-dependent protein kinase IV. J Biochem 115: 637-40 PubMed GONUTS page
- ↑ Fukushima H et al. (2008) Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging. J Neurosci 28: 9910-9 PubMed GONUTS page
- ↑ 3.0 3.1 Racioppi L & Means AR (2008) Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller. Trends Immunol 29: 600-7 PubMed GONUTS page
- ↑ 4.0 4.1 Illario M et al. (2008) Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. Blood 111: 723-31 PubMed GONUTS page
- ↑ Enslen H et al. (1996) Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. Proc Natl Acad Sci U S A 93: 10803-8 PubMed GONUTS page
- ↑ Mosialos G et al. (1994) A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. J Virol 68: 1697-705 PubMed GONUTS page
