HUMAN:JIP1

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	MAPK8IP1 ( synonyms: IB1, JIP1, PRKM8IP )
Protein Name(s)	C-Jun-amino-terminal kinase-interacting protein 1 JIP-1 JNK-interacting protein 1 Islet-brain 1 IB-1 JNK MAP kinase scaffold protein 1 Mitogen-activated protein kinase 8-interacting protein 1
External Links
UniProt Identifier	JIP1_HUMAN
UniProt Accessions	Q9UQF2, D3DQP4, O43407,
EMBL	AF074091, CH471064, CH471064, AF007134,
RefSeq	NP_005447.1,
PDB	2G01, 2GMX, 2H96, 3OXI, 3PTG,
IntAct	Q9UQF2,
Ensembl	ENST00000241014,
Pfam	PF00640, PF00018,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0004860	protein kinase inhibitor activity	PMID:9933567^[1]	TAS: Traceable Author Statement		F
	GO:0005078	MAP-kinase scaffold activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	F
	GO:0005078	MAP-kinase scaffold activity	PMID:11238452^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P45983	F
	GO:0005515	protein binding	PMID:11517249^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P12023	F
	GO:0005515	protein binding	PMID:11517249^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P12023-2	F
	GO:0005515	protein binding	PMID:11724784^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P05067	F
	GO:0005515	protein binding	PMID:11726277^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O43283	F
	GO:0005515	protein binding	PMID:17709393^[6]	IPI: Inferred from Physical Interaction	UniProtKB:O43318	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:10574993^[7]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	C
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	P
	GO:0006916	anti-apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	P
	GO:0006916	anti-apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	P
	GO:0007165	signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	P
	GO:0007258	JUN phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	P
	GO:0008432	JUN kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	F
	GO:0016020	membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0016192	vesicle-mediated transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	P
	GO:0016192	vesicle-mediated transport	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P34609	P
	GO:0019894	kinesin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	F
	GO:0019894	kinesin binding	PMID:11238452^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q07866	F
	GO:0019901	protein kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	F
	GO:0019901	protein kinase binding	PMID:11238452^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P45983	F
	GO:0019901	protein kinase binding	PMID:11726277^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UQF2	F
	GO:0031434	mitogen-activated protein kinase kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	F
	GO:0031435	mitogen-activated protein kinase kinase kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	F
	GO:0043005	neuron projection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0043508	negative regulation of JUN kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	P
	GO:0046328	regulation of JNK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	P
	GO:0046328	regulation of JNK cascade	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9WVI9	P
	GO:0046329	negative regulation of JNK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	P
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	C
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0198	C
	GO:0004860	protein kinase inhibitor activity	PMID:9933567^[1]	TAS: Traceable Author Statement		F
	GO:0005078	MAP-kinase scaffold activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	F
	GO:0005078	MAP-kinase scaffold activity	PMID:11238452^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P45983	F
	GO:0005515	protein binding	PMID:11517249^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P12023	F
	GO:0005515	protein binding	PMID:11517249^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P12023-2	F
	GO:0005515	protein binding	PMID:11724784^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P05067	F
	GO:0005515	protein binding	PMID:11726277^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O43283	F
	GO:0005515	protein binding	PMID:17709393^[6]	IPI: Inferred from Physical Interaction	UniProtKB:O43318	F
	GO:0005624	membrane fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:10574993^[7]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	C
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	P
	GO:0006916	anti-apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	P
	GO:0006916	anti-apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	P
	GO:0007165	signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	P
	GO:0007258	JUN phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	P
	GO:0008432	JUN kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	F
	GO:0016020	membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0016192	vesicle-mediated transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	P
	GO:0016192	vesicle-mediated transport	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P34609	P
	GO:0019894	kinesin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	F
	GO:0019894	kinesin binding	PMID:11238452^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q07866	F
	GO:0019901	protein kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	F
	GO:0019901	protein kinase binding	PMID:11238452^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P45983	F
	GO:0019901	protein kinase binding	PMID:11726277^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UQF2	F
	GO:0030424	axon	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0030425	dendrite	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0031434	mitogen-activated protein kinase kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	F
	GO:0031435	mitogen-activated protein kinase kinase kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	F
	GO:0043005	neuron projection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0043508	negative regulation of JUN kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	P
	GO:0044294	dendritic growth cone	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	C
	GO:0044295	axonal growth cone	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	C
	GO:0044297	cell body	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0044302	dentate gyrus mossy fiber	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0045202	synapse	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	C
	GO:0046328	regulation of JNK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000050773	P
	GO:0046328	regulation of JNK cascade	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9WVI9	P
	GO:0046329	negative regulation of JNK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	P
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009725	C
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0198	C
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Mooser V et al. (1999) Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene. Genomics 55: 202-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Verhey KJ et al. (2001) Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J Cell Biol 152: 959-70 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Matsuda S et al. (2001) c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J Neurosci 21: 6597-607 PubMed GONUTS page
↑ ^4.0 ^4.1 Scheinfeld MH et al. (2002) Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J Biol Chem 277: 3767-75 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Ikeda A et al. (2001) Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. J Biochem 130: 773-81 PubMed GONUTS page
↑ ^6.0 ^6.1 Blanco S et al. (2007) Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. Mol Cell Biol 27: 7273-83 PubMed GONUTS page
↑ ^7.0 ^7.1 Meyer D et al. (1999) Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. J Biol Chem 274: 35113-8 PubMed GONUTS page

[PMID:9933567-0] 1.0 ^1.1 Mooser V et al. (1999) Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene. Genomics 55: 202-8 PubMed GONUTS page

[PMID:11238452-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Verhey KJ et al. (2001) Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J Cell Biol 152: 959-70 PubMed GONUTS page

[PMID:11517249-2] 3.0 ^3.1 ^3.2 ^3.3 Matsuda S et al. (2001) c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J Neurosci 21: 6597-607 PubMed GONUTS page

[PMID:11724784-3] 4.0 ^4.1 Scheinfeld MH et al. (2002) Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J Biol Chem 277: 3767-75 PubMed GONUTS page

[PMID:11726277-4] 5.0 ^5.1 ^5.2 ^5.3 Ikeda A et al. (2001) Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. J Biochem 130: 773-81 PubMed GONUTS page

[PMID:17709393-5] 6.0 ^6.1 Blanco S et al. (2007) Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. Mol Cell Biol 27: 7273-83 PubMed GONUTS page

[PMID:10574993-6] 7.0 ^7.1 Meyer D et al. (1999) Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. J Biol Chem 274: 35113-8 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

HUMAN:JIP1

Contents

Annotations

Notes

References

a

c

d

j

j cont.

k

m

n

n cont.

p

r

s

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox