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HUMAN:INHA
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | INHA | |
| Protein Name(s) | Inhibin alpha chain | |
| External Links | ||
| UniProt | P05111 | |
| EMBL | M13981 X04445 X04446 BT006954 AK292340 CH471063 BC006391 M13144 | |
| IPI | IPI00007080 | |
| PIR | A23556 | |
| RefSeq | NP_002182.1 | |
| UniGene | Hs.407506 | |
| ProteinModelPortal | P05111 | |
| SMR | P05111 | |
| DIP | DIP-5826N | |
| STRING | P05111 | |
| PhosphoSite | P05111 | |
| DMDM | 124274 | |
| PRIDE | P05111 | |
| Ensembl | ENST00000243786 | |
| GeneID | 3623 | |
| KEGG | hsa:3623 | |
| UCSC | uc002vmk.1 | |
| CTD | 3623 | |
| GeneCards | GC02P220433 | |
| HGNC | HGNC:6065 | |
| HPA | CAB000047 HPA019141 | |
| MIM | 147380 | |
| neXtProt | NX_P05111 | |
| PharmGKB | PA29876 | |
| eggNOG | prNOG05386 | |
| GeneTree | ENSGT00390000005935 | |
| HOGENOM | HBG280335 | |
| HOVERGEN | HBG052131 | |
| InParanoid | P05111 | |
| OMA | YSFKYET | |
| OrthoDB | EOG447FTZ | |
| PhylomeDB | P05111 | |
| NextBio | 14177 | |
| ArrayExpress | P05111 | |
| Bgee | P05111 | |
| CleanEx | HS_INHA | |
| Genevestigator | P05111 | |
| GermOnline | ENSG00000123999 | |
| GO | GO:0043512 GO:0034673 GO:0005125 GO:0008083 GO:0005179 GO:0007050 GO:0007166 GO:0007267 GO:0030218 GO:0042541 GO:0006917 GO:0045578 GO:0046882 GO:0045077 GO:0045650 GO:0042326 GO:0007399 GO:0001541 GO:0046881 GO:0042127 GO:0009605 GO:0001501 | |
| InterPro | IPR002405 IPR017175 IPR001839 IPR017948 | |
| KO | K05500 | |
| Pfam | PF00019 | |
| PIRSF | PIRSF037328 | |
| PRINTS | PR00669 | |
| SMART | SM00204 | |
| PROSITE | PS00250 PS51362 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001501 |
skeletal system development |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0001541 |
ovarian follicle development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000027227 |
P |
Seeded From UniProt |
|||
| GO:0001541 |
ovarian follicle development |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0001750 |
photoreceptor outer segment |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000027227 |
C |
Seeded From UniProt |
|||
| GO:0001917 |
photoreceptor inner segment |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000027227 |
C |
Seeded From UniProt |
|||
| GO:0005102 |
receptor binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005125 |
cytokine activity |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005179 |
hormone activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005179 |
hormone activity |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005179 |
hormone activity |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0243 |
C |
Seeded From UniProt |
|||
| GO:0005576 |
extracellular region |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005576 |
extracellular region |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005576 |
extracellular region |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005615 |
extracellular space |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000027227 |
C |
Seeded From UniProt |
|||
| GO:0006917 |
induction of apoptosis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0007050 |
cell cycle arrest |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007165 |
signal transduction |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007166 |
cell surface receptor signaling pathway |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007166 |
cell surface receptor signaling pathway |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007267 |
cell-cell signaling |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007267 |
cell-cell signaling |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007399 |
nervous system development |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0008083 |
growth factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008083 |
growth factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008083 |
growth factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008083 |
growth factor activity |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0008584 |
male gonad development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000027227 |
P |
Seeded From UniProt |
|||
| GO:0009605 |
response to external stimulus |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0030154 |
cell differentiation |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0030218 |
erythrocyte differentiation |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0034673 |
inhibin-betaglycan-ActRII complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0042127 |
regulation of cell proliferation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0042326 |
negative regulation of phosphorylation |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0042541 |
hemoglobin biosynthetic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043025 |
neuronal cell body |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000027227 |
C |
Seeded From UniProt |
|||
| GO:0043512 |
inhibin A complex |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000027227 |
C |
Seeded From UniProt |
|||
| GO:0043512 |
inhibin A complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0045077 |
negative regulation of interferon-gamma biosynthetic process |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0045578 |
negative regulation of B cell differentiation |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0045650 |
negative regulation of macrophage differentiation |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0045786 |
negative regulation of cell cycle |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0046881 |
positive regulation of follicle-stimulating hormone secretion |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0046882 |
negative regulation of follicle-stimulating hormone secretion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000027227 |
P |
Seeded From UniProt |
|||
| GO:0046882 |
negative regulation of follicle-stimulating hormone secretion |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0046982 |
protein heterodimerization activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000027227 |
F |
Seeded From UniProt |
|||
| GO:0048186 |
inhibin beta-A binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000027227 |
F |
Seeded From UniProt |
|||
| GO:0051726 |
regulation of cell cycle |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
| |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Sakai R et al. (2000) Activin increases bone mass and mechanical strength of lumbar vertebrae in aged ovariectomized rats. Bone 27: 91-6 PubMed GONUTS page
- ↑ Evans LW et al. (1997) Development, validation and application of a two-site enzyme-linked immunosorbent assay for activin-AB. J Endocrinol 153: 221-30 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Lebrun JJ & Vale WW (1997) Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation. Mol Cell Biol 17: 1682-91 PubMed GONUTS page
- ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 Shav-Tal Y & Zipori D (2002) The role of activin a in regulation of hemopoiesis. Stem Cells 20: 493-500 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Ramasharma K & Li CH (1987) Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes. Proc Natl Acad Sci U S A 84: 3595-8 PubMed GONUTS page
- ↑ Schneyer A et al. (2003) Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG). Endocrinology 144: 1671-4 PubMed GONUTS page
- ↑ Mason AJ et al. (1989) Activin B: precursor sequences, genomic structure and in vitro activities. Mol Endocrinol 3: 1352-8 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Murata M et al. (1988) Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain. Proc Natl Acad Sci U S A 85: 2434-8 PubMed GONUTS page
- ↑ Nishihara T et al. (1993) Activin A induces apoptotic cell death. Biochem Biophys Res Commun 197: 985-91 PubMed GONUTS page
- ↑ 10.0 10.1 Munz B et al. (1999) A novel role of activin in inflammation and repair. J Endocrinol 161: 187-93 PubMed GONUTS page
- ↑ Welt C et al. (2002) Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. Exp Biol Med (Maywood) 227: 724-52 PubMed GONUTS page
- ↑ 12.0 12.1 Shao L et al. (1992) Effect of activin A on globin gene expression in purified human erythroid progenitors. Blood 79: 773-81 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Lewis KA et al. (2000) Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature 404: 411-4 PubMed GONUTS page
- ↑ Xu J et al. (1995) Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J Biol Chem 270: 6308-13 PubMed GONUTS page
