HUMAN:IL23R

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	IL23R
Protein Name(s)	Interleukin-23 receptor IL-23 receptor IL-23R
External Links
UniProt Identifier	IL23R_HUMAN
UniProt Accessions	Q5VWK5, C9JGX4, Q4VGP1, Q4VGP2, Q4VGP3, Q4VGP4, Q4VGP5, Q4VGP6, Q5VWK7, Q8IW84, Q8NFQ9, Q96AS1,
EMBL	AF461422, AY937250, AY937251, AY937252, AY937253, AY937254, AY937255, AL389925, AL109843, AL389925, AL109843, AL109843, AL389925, AL109843, AL389925, BC016829, BC040720,
RefSeq	NP_653302.2,
Ensembl	ENST00000347310,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0032735	positive regulation of interleukin-12 production	PMID:20027291^[1]	IDA: Inferred from Direct Assay		P
	GO:0042104	positive regulation of activated T cell proliferation	PMID:11114383^[2]	IC: Inferred by Curator	GO:0042019	P
	GO:0006954	inflammatory response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0395	P
	GO:0032496	response to lipopolysaccharide	PMID:12023369^[3]	IDA: Inferred from Direct Assay		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0042020	interleukin-23 receptor activity	PMID:12023369^[3]	IDA: Inferred from Direct Assay		F
	GO:0032819	positive regulation of natural killer cell proliferation	PMID:19088061^[4]	IC: Inferred by Curator	GO:0042019	P
	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	PMID:19088061^[4]	IC: Inferred by Curator	GO:0042019	P
	GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein	PMID:12023369^[3]	IC: Inferred by Curator	GO:0042019	P
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0002230	positive regulation of defense response to virus by host	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EQ14	P
	GO:2000330	positive regulation of T-helper 17 cell lineage commitment	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EQ14	P
	GO:0045672	positive regulation of osteoclast differentiation	PMID:17888176^[5]	IC: Inferred by Curator	GO:0042019	P
	GO:0051135	positive regulation of NK T cell activation	PMID:19088061^[4]	IC: Inferred by Curator	GO:0042019	P
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0032729	positive regulation of interferon-gamma production	PMID:19088061^[4]	TAS: Traceable Author Statement		P
	GO:0005143	interleukin-12 receptor binding	PMID:12023369^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P42701	F
	GO:0001916	positive regulation of T cell mediated cytotoxicity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EQ14	P
	GO:0002230	positive regulation of defense response to virus by host	PMID:12421946^[6]	IDA: Inferred from Direct Assay		P
	GO:0010535	positive regulation of activation of JAK2 kinase activity	PMID:12023369^[3]	IC: Inferred by Curator	GO:0042019	P
	GO:0042102	positive regulation of T cell proliferation	PMID:12023369^[3]	IC: Inferred by Curator	GO:0042019	P
	GO:0032693	negative regulation of interleukin-10 production	PMID:16751425^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein	PMID:19088061^[4]	IC: Inferred by Curator	GO:0042019	P
	GO:0032740	positive regulation of interleukin-17 production	PMID:17888176^[5]	IC: Inferred by Curator	GO:0042019	P
	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	PMID:20027291^[1]	IC: Inferred by Curator	GO:0042019	P
	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	PMID:12023369^[3]	IC: Inferred by Curator	GO:0042019	P
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0002827	positive regulation of T-helper 1 type immune response	PMID:15114670^[8]	IDA: Inferred from Direct Assay		P
	GO:0042019	interleukin-23 binding	PMID:12023369^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPF7	F
	GO:0032729	positive regulation of interferon-gamma production	PMID:20027291^[1]	IC: Inferred by Curator	GO:0042019	P
	GO:0043382	positive regulation of memory T cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EQ14	P
	GO:0050829	defense response to Gram-negative bacterium	PMID:15114670^[8]	IC: Inferred by Curator	GO:0042019	P
	GO:2000318	positive regulation of T-helper 17 type immune response	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EQ14	P
	GO:0034341	response to interferon-gamma	PMID:12023369^[3]	IDA: Inferred from Direct Assay		P
	GO:0002827	positive regulation of T-helper 1 type immune response	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EQ14	P
	GO:0072536	interleukin-23 receptor complex	PMID:12023369^[3]	IDA: Inferred from Direct Assay		C
	GO:0032729	positive regulation of interferon-gamma production	PMID:11114383^[2]	IDA: Inferred from Direct Assay		P
	GO:0045087	innate immune response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0399	P
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0001916	positive regulation of T cell mediated cytotoxicity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EQ14	P
	GO:0002230	positive regulation of defense response to virus by host	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EQ14	P
	GO:0002230	positive regulation of defense response to virus by host	PMID:12421946^[6]	IDA: Inferred from Direct Assay		P
	GO:0002827	positive regulation of T-helper 1 type immune response	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EQ14	P
	GO:0002827	positive regulation of T-helper 1 type immune response	PMID:15114670^[8]	IDA: Inferred from Direct Assay		P
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0006954	inflammatory response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0395	P
	GO:0010535	positive regulation of activation of JAK2 kinase activity	PMID:12023369^[3]	IC: Inferred by Curator	GO:0042019	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0032496	response to lipopolysaccharide	PMID:12023369^[3]	IDA: Inferred from Direct Assay		P
	GO:0032693	negative regulation of interleukin-10 production	PMID:16751425^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	PMID:20027291^[1]	IC: Inferred by Curator	GO:0042019	P
	GO:0032729	positive regulation of interferon-gamma production	PMID:11114383^[2]	IDA: Inferred from Direct Assay		P
	GO:0032729	positive regulation of interferon-gamma production	PMID:19088061^[4]	TAS: Traceable Author Statement		P
	GO:0032729	positive regulation of interferon-gamma production	PMID:20027291^[1]	IC: Inferred by Curator	GO:0042019	P
	GO:0032735	positive regulation of interleukin-12 production	PMID:20027291^[1]	IDA: Inferred from Direct Assay		P
	GO:0032740	positive regulation of interleukin-17 production	PMID:17888176^[5]	IC: Inferred by Curator	GO:0042019	P
	GO:0032819	positive regulation of natural killer cell proliferation	PMID:19088061^[4]	IC: Inferred by Curator	GO:0042019	P
	GO:0034341	response to interferon-gamma	PMID:12023369^[3]	IDA: Inferred from Direct Assay		P
	GO:0042102	positive regulation of T cell proliferation	PMID:12023369^[3]	IC: Inferred by Curator	GO:0042019	P
	GO:0042104	positive regulation of activated T cell proliferation	PMID:11114383^[2]	IC: Inferred by Curator	GO:0042019	P
	GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein	PMID:12023369^[3]	IC: Inferred by Curator	GO:0042019	P
	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	PMID:19088061^[4]	IC: Inferred by Curator	GO:0042019	P
	GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein	PMID:19088061^[4]	IC: Inferred by Curator	GO:0042019	P
	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	PMID:12023369^[3]	IC: Inferred by Curator	GO:0042019	P
	GO:0043382	positive regulation of memory T cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EQ14	P
	GO:0045087	innate immune response	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0399	P
	GO:0045672	positive regulation of osteoclast differentiation	PMID:17888176^[5]	IC: Inferred by Curator	GO:0042019	P
	GO:0050829	defense response to Gram-negative bacterium	PMID:15114670^[8]	IC: Inferred by Curator	GO:0042019	P
	GO:0051135	positive regulation of NK T cell activation	PMID:19088061^[4]	IC: Inferred by Curator	GO:0042019	P
	GO:0072536	interleukin-23 receptor complex	PMID:12023369^[3]	IDA: Inferred from Direct Assay		C
	GO:2000318	positive regulation of T-helper 17 type immune response	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EQ14	P
	GO:2000330	positive regulation of T-helper 17 cell lineage commitment	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9EQ14	P
contributes_to	GO:0005143	interleukin-12 receptor binding	PMID:12023369^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P42701	F
contributes_to	GO:0042019	interleukin-23 binding	PMID:12023369^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPF7	F
contributes_to	GO:0042020	interleukin-23 receptor activity	PMID:12023369^[3]	IDA: Inferred from Direct Assay		F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 van de Wetering D et al. (2009) Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells. PLoS One 4: e8396 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Oppmann B et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-25 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 ^3.19 Parham C et al. (2002) A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol 168: 5699-708 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 van de Wetering D et al. (2009) IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12. Int Immunol 21: 145-53 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Yago T et al. (2007) IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res Ther 9: R96 PubMed GONUTS page
↑ ^6.0 ^6.1 Pirhonen J et al. (2002) Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. J Immunol 169: 5673-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Vaknin-Dembinsky A et al. (2006) IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol 176: 7768-74 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Smits HH et al. (2004) Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur J Immunol 34: 1371-80 PubMed GONUTS page

[PMID:20027291-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 van de Wetering D et al. (2009) Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells. PLoS One 4: e8396 PubMed GONUTS page

[PMID:11114383-1] 2.0 ^2.1 ^2.2 ^2.3 Oppmann B et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-25 PubMed GONUTS page

[PMID:12023369-2] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 ^3.19 Parham C et al. (2002) A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol 168: 5699-708 PubMed GONUTS page

[PMID:19088061-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 van de Wetering D et al. (2009) IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12. Int Immunol 21: 145-53 PubMed GONUTS page

[PMID:17888176-4] 5.0 ^5.1 ^5.2 ^5.3 Yago T et al. (2007) IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res Ther 9: R96 PubMed GONUTS page

[PMID:12421946-5] 6.0 ^6.1 Pirhonen J et al. (2002) Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. J Immunol 169: 5673-8 PubMed GONUTS page

[PMID:16751425-6] 7.0 ^7.1 Vaknin-Dembinsky A et al. (2006) IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol 176: 7768-74 PubMed GONUTS page

[PMID:15114670-7] 8.0 ^8.1 ^8.2 ^8.3 Smits HH et al. (2004) Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur J Immunol 34: 1371-80 PubMed GONUTS page

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HUMAN:IL23R

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