HUMAN:IL10

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	IL10
Protein Name(s)	Interleukin-10 IL-10 Cytokine synthesis inhibitory factor CSIF
External Links
EMBL	M57627 U16720 AY029171 AF418271
IPI	IPI00026102
PIR	A38580
RefSeq	NP_000563.1
UniGene	Hs.193717
PDB	1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK
PDBsum	1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK
ProteinModelPortal	P22301
SMR	P22301
DIP	DIP-3511N
IntAct	P22301
MINT	MINT-206740
STRING	P22301
PRIDE	P22301
Ensembl	ENST00000423557
GeneID	3586
KEGG	hsa:3586
UCSC	uc001hen.1
CTD	3586
GeneCards	GC01M177639
H-InvDB	HIX0023529
HGNC	HGNC:5962
HPA	CAB013120
MIM	124092
neXtProt	NX_P22301
Orphanet	117 206
PharmGKB	PA29778
eggNOG	prNOG19191
HOGENOM	HBG279172
HOVERGEN	HBG004110
InParanoid	P22301
OMA	KGYLGCQ
OrthoDB	EOG4F1X4G
PhylomeDB	P22301
Pathway_Interaction_DB	il4_2pathway smad2_3nuclearpathway
NextBio	14011
ArrayExpress	P22301
Bgee	P22301
CleanEx	HS_IL10
Genevestigator	P22301
GermOnline	ENSG00000136634
GO	GO:0005615 GO:0005125 GO:0008083 GO:0005141 GO:0006916 GO:0030183 GO:0042100 GO:0007253 GO:0006954 GO:0030595 GO:0030889 GO:0002740 GO:0045355 GO:0032715 GO:0051045 GO:0045347 GO:0042130 GO:0002904 GO:0050715 GO:0051091 GO:0045893 GO:0032800 GO:0045191 GO:0051384 GO:0042092
InterPro	IPR009079 IPR012351 IPR020443 IPR020423 IPR000098
Gene3D	G3DSA:1.20.1250.10
PANTHER	PTHR11585
Pfam	PF00726
PRINTS	PR01294
SMART	SM00188
SUPFAM	SSF47266
PROSITE	PS00520

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0001818	negative regulation of cytokine production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0002237	response to molecule of bacterial origin	PMID:17449476^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0002740	negative regulation of cytokine secretion involved in immune response	PMID:10443688^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0002904	positive regulation of B cell apoptosis	PMID:9184696^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0005125	cytokine activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000098	F	Seeded From UniProt
	GO:0005125	cytokine activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	F	Seeded From UniProt
	GO:0005125	cytokine activity	PMID:10443688^[2]	NAS: Non-traceable Author Statement		F	Seeded From UniProt
	GO:0005141	interleukin-10 receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	F	Seeded From UniProt
	GO:0005141	interleukin-10 receptor binding	PMID:1847510^[4]	NAS: Non-traceable Author Statement		F	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000098	C	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	C	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C	Seeded From UniProt
	GO:0005615	extracellular space	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	C	Seeded From UniProt
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	C	Seeded From UniProt
	GO:0005615	extracellular space	PMID:10443688^[2]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0006916	anti-apoptosis	PMID:8312229^[5]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0006950	response to stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0006954	inflammatory response	PMID:10443688^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000098	P	Seeded From UniProt
	GO:0006955	immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0007253	cytoplasmic sequestering of NF-kappaB	PMID:10975994^[6]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0007267	cell-cell signaling	PMID:1847510^[4]	IC: Inferred by Curator	GO:0005141	P	Seeded From UniProt
	GO:0008083	growth factor activity	PMID:1371884^[7]	NAS: Non-traceable Author Statement		F	Seeded From UniProt
	GO:0010033	response to organic substance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0010468	regulation of gene expression	PMID:9184696^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0014823	response to activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0030097	hemopoiesis	PMID:11244051^[8]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0030183	B cell differentiation	PMID:8228801^[9]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0030595	leukocyte chemotaxis	PMID:9405662^[10]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0030889	negative regulation of B cell proliferation	PMID:9184696^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0032496	response to lipopolysaccharide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0032715	negative regulation of interleukin-6 production	PMID:10443688^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0032800	receptor biosynthetic process	PMID:10443688^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0032868	response to insulin stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0034465	response to carbon monoxide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0042092	type 2 immune response	PMID:11244051^[8]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0042100	B cell proliferation	PMID:8228801^[9]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0042130	negative regulation of T cell proliferation	PMID:8499633^[11]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0045019	negative regulation of nitric oxide biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0045191	regulation of isotype switching	PMID:8228801^[9]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0045347	negative regulation of MHC class II biosynthetic process	PMID:11244051^[8]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0045355	negative regulation of interferon-alpha biosynthetic process	PMID:9637497^[12]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:7749983^[13]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0050715	positive regulation of cytokine secretion	PMID:10443688^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0050728	negative regulation of inflammatory response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	PMID:18383040^[14]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	PMID:7749983^[13]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0051384	response to glucocorticoid stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0051384	response to glucocorticoid stimulus	PMID:10443688^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0051930	regulation of sensory perception of pain	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000006246	P	Seeded From UniProt
	GO:0060302	negative regulation of cytokine activity	PMID:9847016^[15]	IMP: Inferred from Mutant Phenotype		P	Figures 1-3	complete
	GO:0050728	negative regulation of inflammatory response	PMID:9847016^[15]	IMP: Inferred from Mutant Phenotype		P	Figures 1-3	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lella RK & Sharma C (2007) Eis (enhanced intracellular survival) protein of Mycobacterium tuberculosis disturbs the cross regulation of T-cells. J Biol Chem 282: 18671-5 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Franchimont D et al. (1999) Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J Clin Endocrinol Metab 84: 2834-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Li L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell Immunol 178: 33-41 PubMed GONUTS page
↑ ^4.0 ^4.1 Vieira P et al. (1991) Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc Natl Acad Sci U S A 88: 1172-6 PubMed GONUTS page
↑ Taga K et al. (1993) IL-10 inhibits apoptotic cell death in human T cells starved of IL-2. Int Immunol 5: 1599-608 PubMed GONUTS page
↑ Raychaudhuri B et al. (2000) Interleukin 10 (IL-10)-mediated inhibition of inflammatory cytokine production by human alveolar macrophages. Cytokine 12: 1348-55 PubMed GONUTS page
↑ Rousset F et al. (1992) Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci U S A 89: 1890-3 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Moore KW et al. (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19: 683-765 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Fluckiger AC et al. (1993) Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. J Exp Med 178: 1473-81 PubMed GONUTS page
↑ Gesser B et al. (1997) Identification of functional domains on human interleukin 10. Proc Natl Acad Sci U S A 94: 14620-5 PubMed GONUTS page
↑ Taga K et al. (1993) Human interleukin-10 can directly inhibit T-cell growth. Blood 81: 2964-71 PubMed GONUTS page
↑ Payvandi F et al. (1998) Exogenous and endogenous IL-10 regulate IFN-alpha production by peripheral blood mononuclear cells in response to viral stimulation. J Immunol 160: 5861-8 PubMed GONUTS page
↑ ^13.0 ^13.1 Stüber E et al. (1995) Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 2: 507-21 PubMed GONUTS page
↑ Brennan FM et al. (2008) Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism. Eur J Immunol 38: 1106-17 PubMed GONUTS page
↑ ^15.0 ^15.1 Hawkins DL et al. (1998) Human interleukin 10 suppresses production of inflammatory mediators by LPS-stimulated equine peritoneal macrophages. Vet Immunol Immunopathol 66: 1-10 PubMed GONUTS page

[PMID:17449476-0] Lella RK & Sharma C (2007) Eis (enhanced intracellular survival) protein of Mycobacterium tuberculosis disturbs the cross regulation of T-cells. J Biol Chem 282: 18671-5 PubMed GONUTS page

[PMID:10443688-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Franchimont D et al. (1999) Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J Clin Endocrinol Metab 84: 2834-9 PubMed GONUTS page

[PMID:9184696-2] 3.0 ^3.1 ^3.2 Li L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell Immunol 178: 33-41 PubMed GONUTS page

[PMID:1847510-3] 4.0 ^4.1 Vieira P et al. (1991) Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc Natl Acad Sci U S A 88: 1172-6 PubMed GONUTS page

[PMID:8312229-4] Taga K et al. (1993) IL-10 inhibits apoptotic cell death in human T cells starved of IL-2. Int Immunol 5: 1599-608 PubMed GONUTS page

[PMID:10975994-5] Raychaudhuri B et al. (2000) Interleukin 10 (IL-10)-mediated inhibition of inflammatory cytokine production by human alveolar macrophages. Cytokine 12: 1348-55 PubMed GONUTS page

[PMID:1371884-6] Rousset F et al. (1992) Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci U S A 89: 1890-3 PubMed GONUTS page

[PMID:11244051-7] 8.0 ^8.1 ^8.2 Moore KW et al. (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19: 683-765 PubMed GONUTS page

[PMID:8228801-8] 9.0 ^9.1 ^9.2 Fluckiger AC et al. (1993) Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. J Exp Med 178: 1473-81 PubMed GONUTS page

[PMID:9405662-9] Gesser B et al. (1997) Identification of functional domains on human interleukin 10. Proc Natl Acad Sci U S A 94: 14620-5 PubMed GONUTS page

[PMID:8499633-10] Taga K et al. (1993) Human interleukin-10 can directly inhibit T-cell growth. Blood 81: 2964-71 PubMed GONUTS page

[PMID:9637497-11] Payvandi F et al. (1998) Exogenous and endogenous IL-10 regulate IFN-alpha production by peripheral blood mononuclear cells in response to viral stimulation. J Immunol 160: 5861-8 PubMed GONUTS page

[PMID:7749983-12] 13.0 ^13.1 Stüber E et al. (1995) Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 2: 507-21 PubMed GONUTS page

[PMID:18383040-13] Brennan FM et al. (2008) Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism. Eur J Immunol 38: 1106-17 PubMed GONUTS page

[PMID:9847016-14] 15.0 ^15.1 Hawkins DL et al. (1998) Human interleukin 10 suppresses production of inflammatory mediators by LPS-stimulated equine peritoneal macrophages. Vet Immunol Immunopathol 66: 1-10 PubMed GONUTS page

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HUMAN:IL10

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