HUMAN:IGF1R

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Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IGF1R
Protein Name(s)	Insulin-like growth factor 1 receptor Insulin-like growth factor I receptor IGF-I receptor Insulin-like growth factor 1 receptor alpha chain Insulin-like growth factor 1 receptor beta chain
External Links
UniProt	P08069
EMBL	X04434 AB425196 AY332722 AC055807 AC069029 AC118658 AC118660 BC113610 BC113612 M69229
IPI	IPI00027232
PIR	A25690
RefSeq	NP_000866.1
UniGene	Hs.643120 Hs.653608 Hs.714012
PDB	1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU
PDBsum	1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU
ProteinModelPortal	P08069
SMR	P08069
DIP	DIP-476N
IntAct	P08069
MINT	MINT-85902
STRING	P08069
PhosphoSite	P08069
DMDM	124240
PeptideAtlas	P08069
PRIDE	P08069
Ensembl	ENST00000268035
GeneID	3480
KEGG	hsa:3480
UCSC	uc002bul.1
CTD	3480
GeneCards	GC15P099192
H-InvDB	HIX0038072
HGNC	HGNC:5465
HPA	CAB010268
MIM	147370 270450
neXtProt	NX_P08069
Orphanet	73273
PharmGKB	PA29698
eggNOG	prNOG04495
GeneTree	ENSGT00600000084075
HOGENOM	HBG316019
HOVERGEN	HBG006134
InParanoid	P08069
OMA	TTINNEY
OrthoDB	EOG4Z62MR
PhylomeDB	P08069
BRENDA	2.7.10.1
Pathway_Interaction_DB	igf1_pathway avb3_integrin_pathway er_nongenomic_pathway
DrugBank	DB00047 DB00046 DB00030 DB00071 DB01277
NextBio	13682
ArrayExpress	P08069
Bgee	P08069
CleanEx	HS_IGF1R
Genevestigator	P08069
GermOnline	ENSG00000140443
GO	GO:0005887 GO:0005792 GO:0005524 GO:0042802 GO:0043559 GO:0005158 GO:0043560 GO:0031994 GO:0005010 GO:0046872 GO:0043548 GO:0006916 GO:0006955 GO:0008286 GO:0014065 GO:0030335 GO:0008284 GO:0045740 GO:0046777 GO:0051262
InterPro	IPR000494 IPR003961 IPR006211 IPR006212 IPR009030 IPR013783 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 IPR016246 IPR002011
Gene3D	G3DSA:2.60.40.10
KO	K05087
Pfam	PF00041 PF00757 PF07714 PF01030
PIRSF	PIRSF000620
PRINTS	PR00109
SMART	SM00060 SM00261 SM00219
SUPFAM	SSF49265 SSF57184 SSF56112
PROSITE	PS50853 PS00107 PS50011 PS00109 PS00239

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020635	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0829	F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	PMID:11162456^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0004713	protein tyrosine kinase activity	PMID:7679099^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	F	Seeded From UniProt
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	F	Seeded From UniProt
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	F	Seeded From UniProt
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	F	Seeded From UniProt
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F	Seeded From UniProt
	GO:0005010	insulin-like growth factor-activated receptor activity	PMID:10749889^[3]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0005010	insulin-like growth factor-activated receptor activity	PMID:7679099^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005158	insulin receptor binding	PMID:8452530^[4]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12482592^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P61981	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12556535^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q99683	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:15878855^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P49407	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:15998644^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P40763	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:7541045^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P29353	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:7541045^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P29353-2	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:9727029^[10]	IPI: Inferred from Physical Interaction	UniProtKB:O14508	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:9727029^[10]	IPI: Inferred from Physical Interaction	UniProtKB:O15524	F	Seeded From UniProt
	GO:0005520	insulin-like growth factor binding	PMID:1846292^[11]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005520	insulin-like growth factor binding	PMID:7679099^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded From UniProt
	GO:0005792	microsome	PMID:8452530^[4]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005671	C	Seeded From UniProt
	GO:0005887	integral to plasma membrane	PMID:7679099^[2]	IC: Inferred by Curator	GO:0005010	C	Seeded From UniProt
	GO:0005901	caveola	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	C	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020635	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005671	P	Seeded From UniProt
	GO:0006916	anti-apoptosis	PMID:8710868^[12]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006955	immune response	PMID:16886151^[13]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007165	signal transduction	PMID:3003744^[14]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	P	Seeded From UniProt
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	P	Seeded From UniProt
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	P	Seeded From UniProt
	GO:0007409	axonogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0007420	brain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005671	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:10749889^[3]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0008286	insulin receptor signaling pathway	PMID:10829031^[15]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0009887	organ morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005671	P	Seeded From UniProt
	GO:0014065	phosphatidylinositol 3-kinase cascade	PMID:7541045^[9]	IC: Inferred by Curator	GO:0043548	P	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000494	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002011	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006211	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C	Seeded From UniProt
	GO:0016020	membrane	PMID:8452530^[4]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded From UniProt
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded From UniProt
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded From UniProt
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	Seeded From UniProt
	GO:0030010	establishment of cell polarity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0030238	male sex determination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005671	P	Seeded From UniProt
	GO:0030335	positive regulation of cell migration	PMID:12138094^[16]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0030879	mammary gland development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005671	P	Seeded From UniProt
	GO:0031017	exocrine pancreas development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005671	P	Seeded From UniProt
	GO:0031175	neuron projection development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0031994	insulin-like growth factor I binding	PMID:8452530^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P05019	F	Seeded From UniProt
	GO:0032467	positive regulation of cytokinesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0033197	response to vitamin E	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0042802	identical protein binding	PMID:11448933^[17]	IPI: Inferred from Physical Interaction	UniProtKB:P08069	F	Seeded From UniProt
	GO:0043005	neuron projection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	C	Seeded From UniProt
	GO:0043066	negative regulation of apoptotic process	PMID:12556535^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0043409	negative regulation of MAPK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005671	P	Seeded From UniProt
	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005671	P	Seeded From UniProt
	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	F	Seeded From UniProt
	GO:0043548	phosphatidylinositol 3-kinase binding	PMID:7541045^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P27986	F	Seeded From UniProt
	GO:0043559	insulin binding	PMID:8452530^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P01308	F	Seeded From UniProt
	GO:0043560	insulin receptor substrate binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	F	Seeded From UniProt
	GO:0043560	insulin receptor substrate binding	PMID:7541045^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P35568	F	Seeded From UniProt
	GO:0045740	positive regulation of DNA replication	PMID:12138094^[16]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045768	positive regulation of anti-apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0046328	regulation of JNK cascade	PMID:12556535^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	PMID:11162456^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	PMID:1846292^[11]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	PMID:7679099^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0048009	insulin-like growth factor receptor signaling pathway	PMID:10749889^[3]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0048009	insulin-like growth factor receptor signaling pathway	PMID:7679099^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0048015	phosphatidylinositol-mediated signaling	PMID:7692086^[18]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0051054	positive regulation of DNA metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0051262	protein tetramerization	PMID:1846292^[11]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0051291	protein heterooligomerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0051389	inactivation of MAPKK activity	PMID:12556535^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0051897	positive regulation of protein kinase B signaling cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005671	P	Seeded From UniProt
	GO:0051898	negative regulation of protein kinase B signaling cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005671	P	Seeded From UniProt
	GO:0060740	prostate gland epithelium morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000005671	P	Seeded From UniProt
	GO:0090031	positive regulation of steroid hormone biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019267	P	Seeded From UniProt
	GO:0004713		PMID:11884589^[19]	IMP: Inferred from Mutant Phenotype			Fig1B	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Lopaczynski W et al. (2000) Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain. Biochem Biophys Res Commun 279: 955-60 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Kato H et al. (1993) Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3). J Biol Chem 268: 2655-61 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Kahlert S et al. (2000) Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway. J Biol Chem 275: 18447-53 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Soos MA et al. (1993) Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem J 290 ( Pt 2): 419-26 PubMed GONUTS page
↑ Parvaresch S et al. (2002) 14-3-3 binding to the IGF-1 receptor is mediated by serine autophosphorylation. FEBS Lett 532: 357-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Galvan V et al. (2003) Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1). J Biol Chem 278: 13325-32 PubMed GONUTS page
↑ Girnita L et al. (2005) {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem 280: 24412-9 PubMed GONUTS page
↑ Yadav A et al. (2005) JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3. J Biol Chem 280: 31830-40 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Craparo A et al. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J Biol Chem 270: 15639-43 PubMed GONUTS page
↑ ^10.0 ^10.1 Dey BR et al. (1998) Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. J Biol Chem 273: 24095-101 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Tollefsen SE et al. (1991) Interaction of the alpha beta dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation. Biochemistry 30: 48-54 PubMed GONUTS page
↑ Werner H et al. (1996) Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc Natl Acad Sci U S A 93: 8318-23 PubMed GONUTS page
↑ Adewoye AH et al. (2006) Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia. Clin Infect Dis 43: 593-8 PubMed GONUTS page
↑ Flier JS et al. (1986) Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts. Proc Natl Acad Sci U S A 83: 664-8 PubMed GONUTS page
↑ Fasshauer M et al. (2000) Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. J Biol Chem 275: 25494-501 PubMed GONUTS page
↑ ^16.0 ^16.1 Pandini G et al. (2002) Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J Biol Chem 277: 39684-95 PubMed GONUTS page
↑ Reiss K et al. (2001) Intracellular association of a mutant insulin-like growth factor receptor with endogenous receptors. Clin Cancer Res 7: 2134-44 PubMed GONUTS page
↑ Liu D et al. (1993) Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions. J Virol 67: 6835-40 PubMed GONUTS page
↑ Buckley DA et al. (2002) Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol Cell Biol 22: 1998-2010 PubMed GONUTS page

[PMID:11162456-0] 1.0 ^1.1 Lopaczynski W et al. (2000) Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain. Biochem Biophys Res Commun 279: 955-60 PubMed GONUTS page

[PMID:7679099-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Kato H et al. (1993) Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3). J Biol Chem 268: 2655-61 PubMed GONUTS page

[PMID:10749889-2] 3.0 ^3.1 ^3.2 Kahlert S et al. (2000) Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway. J Biol Chem 275: 18447-53 PubMed GONUTS page

[PMID:8452530-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Soos MA et al. (1993) Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem J 290 ( Pt 2): 419-26 PubMed GONUTS page

[PMID:12482592-4] Parvaresch S et al. (2002) 14-3-3 binding to the IGF-1 receptor is mediated by serine autophosphorylation. FEBS Lett 532: 357-62 PubMed GONUTS page

[PMID:12556535-5] 6.0 ^6.1 ^6.2 ^6.3 Galvan V et al. (2003) Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1). J Biol Chem 278: 13325-32 PubMed GONUTS page

[PMID:15878855-6] Girnita L et al. (2005) {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem 280: 24412-9 PubMed GONUTS page

[PMID:15998644-7] Yadav A et al. (2005) JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3. J Biol Chem 280: 31830-40 PubMed GONUTS page

[PMID:7541045-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Craparo A et al. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J Biol Chem 270: 15639-43 PubMed GONUTS page

[PMID:9727029-9] 10.0 ^10.1 Dey BR et al. (1998) Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. J Biol Chem 273: 24095-101 PubMed GONUTS page

[PMID:1846292-10] 11.0 ^11.1 ^11.2 Tollefsen SE et al. (1991) Interaction of the alpha beta dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation. Biochemistry 30: 48-54 PubMed GONUTS page

[PMID:8710868-11] Werner H et al. (1996) Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc Natl Acad Sci U S A 93: 8318-23 PubMed GONUTS page

[PMID:16886151-12] Adewoye AH et al. (2006) Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia. Clin Infect Dis 43: 593-8 PubMed GONUTS page

[PMID:3003744-13] Flier JS et al. (1986) Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts. Proc Natl Acad Sci U S A 83: 664-8 PubMed GONUTS page

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[PMID:12138094-15] 16.0 ^16.1 Pandini G et al. (2002) Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J Biol Chem 277: 39684-95 PubMed GONUTS page

[PMID:11448933-16] Reiss K et al. (2001) Intracellular association of a mutant insulin-like growth factor receptor with endogenous receptors. Clin Cancer Res 7: 2134-44 PubMed GONUTS page

[PMID:7692086-17] Liu D et al. (1993) Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions. J Virol 67: 6835-40 PubMed GONUTS page

[PMID:11884589-18] Buckley DA et al. (2002) Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol Cell Biol 22: 1998-2010 PubMed GONUTS page

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HUMAN:IGF1R

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