HUMAN:IFNG

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	IFNG
Protein Name(s)	Interferon gamma IFN-gamma Immune interferon
External Links
EMBL	X13274 J00219 X01992 V00543 AY255837 AF375790 AB451324 AB451453 CH471054 BC070256
IPI	IPI00307209
PIR	A93284
RefSeq	NP_000610.2
UniGene	Hs.856
PDB	1EKU 1FG9 1FYH 1HIG 3BES
PDBsum	1EKU 1FG9 1FYH 1HIG 3BES
ProteinModelPortal	P01579
SMR	P01579
DIP	DIP-483N
IntAct	P01579
STRING	P01579
GlycoSuiteDB	P01579
PhosphoSite	P01579
PRIDE	P01579
Ensembl	ENST00000229135
GeneID	3458
KEGG	hsa:3458
UCSC	uc001stw.1
CTD	3458
GeneCards	GC12M065599
H-InvDB	HIX0036727
HGNC	HGNC:5438
HPA	CAB010344
MIM	147570 609135
neXtProt	NX_P01579
Orphanet	88
PharmGKB	PA29674
HOGENOM	HBG127262
HOVERGEN	HBG056912
InParanoid	P01579
OMA	KEYFNAS
OrthoDB	EOG4MCX1G
PhylomeDB	P01579
Pathway_Interaction_DB	nfat_tfpathway tcrcalciumpathway cd8tcrdownstreampathway ifngpathway il12_stat4pathway il12_2pathway il2_1pathway il23pathway il27pathway pdgfrapathway telomerasepathway
Reactome	REACT_6900
DrugBank	DB01296 DB00033 DB00641
NextBio	13624
PMAP-CutDB	P01579
ArrayExpress	P01579
Bgee	P01579
CleanEx	HS_IFNG
Genevestigator	P01579
GermOnline	ENSG00000111537
GO	GO:0005615 GO:0005125 GO:0005133 GO:0007050 GO:0060333 GO:0032700 GO:0003340 GO:0072308 GO:0048662 GO:0000122 GO:0060559 GO:0060550 GO:0060552 GO:0032735 GO:0032747 GO:0051712 GO:0051044 GO:0002053 GO:0045429 GO:0045672 GO:0033141 GO:0034393 GO:2000309 GO:0042511 GO:0060557 GO:0000060 GO:0050796 GO:0060334 GO:0009615
InterPro	IPR009079 IPR012351 IPR002069
Gene3D	G3DSA:1.20.1250.10
PANTHER	PTHR11419
Pfam	PF00714
PIRSF	PIRSF001936
ProDom	PD002435
SUPFAM	SSF47266

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000060	protein import into nucleus, translocation	PMID:15604419^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01581	P	Seeded From UniProt
	GO:0001781	neutrophil apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0002026	regulation of the force of heart contraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009917	P	Seeded From UniProt
	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009917	P	Seeded From UniProt
	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01581	P	Seeded From UniProt
	GO:0002250	adaptive immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009917	P	Seeded From UniProt
	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01581	P	Seeded From UniProt
	GO:0005125	cytokine activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	F	Seeded From UniProt
	GO:0005125	cytokine activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	F	Seeded From UniProt
	GO:0005133	interferon-gamma receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002069	F	Seeded From UniProt
	GO:0005133	interferon-gamma receptor binding	PMID:10477596^[2]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002069	C	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_24928	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_24933	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_24944	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_24993	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_25056	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_25139	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_25158	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_25347	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_25369	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005615	extracellular space	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	C	Seeded From UniProt
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	C	Seeded From UniProt
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009917	C	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0006925	inflammatory cell apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0006928	cellular component movement	PMID:10477596^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002069	P	Seeded From UniProt
	GO:0006959	humoral immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0007050	cell cycle arrest	PMID:16942485^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0007166	cell surface receptor linked signaling pathway	PMID:10477596^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009917	P	Seeded From UniProt
	GO:0009615	response to virus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0051	P	Seeded From UniProt
	GO:0009615	response to virus	PMID:16280321^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0019221	cytokine-mediated signaling pathway	Reactome:REACT_25229	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0019882	antigen processing and presentation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0030593	neutrophil chemotaxis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0030968	endoplasmic reticulum unfolded protein response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0031642	negative regulation of myelination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0032224	positive regulation of synaptic transmission, cholinergic	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009917	P	Seeded From UniProt
	GO:0032700	negative regulation of interleukin-17 production	PMID:18501882^[5]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0032735	positive regulation of interleukin-12 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0032735	positive regulation of interleukin-12 production	PMID:7605994^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0032735	positive regulation of interleukin-12 production	PMID:8557999^[7]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0032747	positive regulation of interleukin-23 production	PMID:20027291^[8]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009917	P	Seeded From UniProt
	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	PMID:16280321^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	PMID:21268089^[9]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0034393	positive regulation of smooth muscle cell apoptosis	PMID:16942485^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0040008	regulation of growth	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0341	P	Seeded From UniProt
	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009917	P	Seeded From UniProt
	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009917	P	Seeded From UniProt
	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein	PMID:15604419^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein	PMID:16280321^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0042742	defense response to bacterium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0042832	defense response to protozoan	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0044146	negative regulation of growth of symbiont involved in interaction with host	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0045080	positive regulation of chemokine biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0045084	positive regulation of interleukin-12 biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0045348	positive regulation of MHC class II biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0045410	positive regulation of interleukin-6 biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:8383325^[10]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009917	P	Seeded From UniProt
	GO:0045672	positive regulation of osteoclast differentiation	PMID:16220542^[11]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045785	positive regulation of cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009917	P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0048304	positive regulation of isotype switching to IgG isotypes	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:16942485^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0050776	regulation of immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000063800	P	Seeded From UniProt
	GO:0050796	regulation of insulin secretion	PMID:8383325^[10]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	PMID:18373975^[12]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0051712	positive regulation of killing of cells of other organism	PMID:7544003^[13]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060333	interferon-gamma-mediated signaling pathway	Reactome:REACT_25078	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0060334	regulation of interferon-gamma-mediated signaling pathway	Reactome:REACT_24980	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0060550	positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity	PMID:9282826^[14]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060552	positive regulation of fructose 1,6-bisphosphate metabolic process	PMID:9282826^[14]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060557	positive regulation of vitamin D biosynthetic process	PMID:9282826^[14]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	PMID:9282826^[14]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0072308	negative regulation of metanephric nephron tubule epithelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000009917	P	Seeded From UniProt
	GO:0072308	negative regulation of metanephric nephron tubule epithelial cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01581	P	Seeded From UniProt
	GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	PMID:16220542^[11]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0008009	chemokine activity	PMID:21962843^[15]	IDA: Inferred from Direct Assay		F	Figure 2. demonstrates the different levels of the chemokines in the serum of humans with and without aortic aneurysms. It is shown that patients with thoracic aortic aneurysms have elevated levels of interferon gamma.	complete
	0071346	Bad GO ID<input type="hidden" name="field[2]" />	PMID:22447512^[16]	IEP: Inferred from Expression Pattern		P	Figures 1A-1D shows interferon gamma induces the accumulation and upregulation of production of frataxin in various human cell lines. The response is concentration dependent.	Missing: Valid GO ID
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Huang A et al. (2005) Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3. Circ Res 96: 164-71 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Kawai T et al. (1999) Selective diapedesis of Th1 cells induced by endothelial cell RANTES. J Immunol 163: 3269-78 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Jia G et al. (2006) Differential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosis. Immunol Cell Biol 84: 422-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Shang L & Tomasi TB (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J Biol Chem 281: 1876-84 PubMed GONUTS page
↑ Li J et al. (2008) Negative regulation of IL-17 production by OX40/OX40L interaction. Cell Immunol 253: 31-7 PubMed GONUTS page
↑ Hayes MP et al. (1995) Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood 86: 646-50 PubMed GONUTS page
↑ Snijders A et al. (1996) Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J Immunol 156: 1207-12 PubMed GONUTS page
↑ van de Wetering D et al. (2009) Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells. PLoS One 4: e8396 PubMed GONUTS page
↑ Li N et al. (2011) Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J Cell Biochem 112: 675-83 PubMed GONUTS page
↑ ^10.0 ^10.1 Corbett JA et al. (1993) Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci U S A 90: 1731-5 PubMed GONUTS page
↑ ^11.0 ^11.1 Kotake S et al. (2005) IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL. Eur J Immunol 35: 3353-63 PubMed GONUTS page
↑ Schramme A et al. (2008) The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells. Biochem Biophys Res Commun 370: 311-6 PubMed GONUTS page
↑ Vouldoukis I et al. (1995) The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen. Proc Natl Acad Sci U S A 92: 7804-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Besançon F et al. (1997) HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase. J Interferon Cytokine Res 17: 461-7 PubMed GONUTS page
↑ Gallo A et al. (2012) Circulating interferon-γ-inducible Cys-X-Cys chemokine receptor 3 ligands are elevated in humans with aortic aneurysms and Cys-X-Cys chemokine receptor 3 is necessary for aneurysm formation in mice. J Thorac Cardiovasc Surg 143: 704-10 PubMed GONUTS page
↑ Tomassini B et al. (2012) Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model. Hum Mol Genet PubMed GONUTS page

[PMID:15604419-0] 1.0 ^1.1 Huang A et al. (2005) Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3. Circ Res 96: 164-71 PubMed GONUTS page

[PMID:10477596-1] 2.0 ^2.1 ^2.2 Kawai T et al. (1999) Selective diapedesis of Th1 cells induced by endothelial cell RANTES. J Immunol 163: 3269-78 PubMed GONUTS page

[PMID:16942485-2] 3.0 ^3.1 ^3.2 Jia G et al. (2006) Differential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosis. Immunol Cell Biol 84: 422-9 PubMed GONUTS page

[PMID:16280321-3] 4.0 ^4.1 ^4.2 Shang L & Tomasi TB (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J Biol Chem 281: 1876-84 PubMed GONUTS page

[PMID:18501882-4] Li J et al. (2008) Negative regulation of IL-17 production by OX40/OX40L interaction. Cell Immunol 253: 31-7 PubMed GONUTS page

[PMID:7605994-5] Hayes MP et al. (1995) Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood 86: 646-50 PubMed GONUTS page

[PMID:8557999-6] Snijders A et al. (1996) Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J Immunol 156: 1207-12 PubMed GONUTS page

[PMID:20027291-7] van de Wetering D et al. (2009) Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells. PLoS One 4: e8396 PubMed GONUTS page

[PMID:21268089-8] Li N et al. (2011) Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J Cell Biochem 112: 675-83 PubMed GONUTS page

[PMID:8383325-9] 10.0 ^10.1 Corbett JA et al. (1993) Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci U S A 90: 1731-5 PubMed GONUTS page

[PMID:16220542-10] 11.0 ^11.1 Kotake S et al. (2005) IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL. Eur J Immunol 35: 3353-63 PubMed GONUTS page

[PMID:18373975-11] Schramme A et al. (2008) The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells. Biochem Biophys Res Commun 370: 311-6 PubMed GONUTS page

[PMID:7544003-12] Vouldoukis I et al. (1995) The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen. Proc Natl Acad Sci U S A 92: 7804-8 PubMed GONUTS page

[PMID:9282826-13] 14.0 ^14.1 ^14.2 ^14.3 Besançon F et al. (1997) HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase. J Interferon Cytokine Res 17: 461-7 PubMed GONUTS page

[PMID:21962843-14] Gallo A et al. (2012) Circulating interferon-γ-inducible Cys-X-Cys chemokine receptor 3 ligands are elevated in humans with aortic aneurysms and Cys-X-Cys chemokine receptor 3 is necessary for aneurysm formation in mice. J Thorac Cardiovasc Surg 143: 704-10 PubMed GONUTS page

[PMID:22447512-15] Tomassini B et al. (2012) Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model. Hum Mol Genet PubMed GONUTS page

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HUMAN:IFNG

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