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HUMAN:IFIT1
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (taxon:9606) | |
| Gene Name(s) | IFIT1 ( synonyms: G10P1, IFI56, IFNAI1 ) | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | IFIT1_HUMAN | |
| UniProt Accessions | P09914, Q96QM5, | |
| EMBL | X03557, BC007091, X06559, | |
| PIR | A25407, | |
| RefSeq | NP_001539.3, | |
| IntAct | P09914, | |
| Ensembl | ENST00000371804, | |
| Pfam | PF00515, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005737 |
cytoplasm |
NAS: Non-traceable Author Statement |
C |
Source: UniProtKB |
||||
| GO:0051117 |
ATPase binding |
IPI: Inferred from Physical Interaction |
|
F |
Figure 1B, 1C, 1D, 3B, 3C and 3D. Co-immunoprecipitation assays and immunofluorescence confirm the binding of ATPase HPV18 E1 to the TPR2 domain of P56 (IFIT1) protein. |
complete | ||
| GO:0005488 |
binding |
IEA: Inferred from Electronic Annotation |
F |
Source: InterPro |
||||
| GO:0051117 |
ATPase binding |
IPI: Inferred from Physical Interaction |
|
F |
Figure S1 and S2. Co-immunoprecipitation assays confirm the binding of ATPase HPV11 E1 to the TPR2 domain of P56 (IFIT1) protein. |
complete | ||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
Figure 1E, panel 2 (left) and 5F (left). Immunofluorescence confirms the location of P56 (IFIT1) in the cytoplasm. |
complete | |||
| GO:0016482 |
cytoplasmic transport |
IDA: Inferred from Direct Assay |
P |
Figure 1B, 1C, 1D and 1E panel 2 (middle). Co-immunoprecipitation and pull-down assays were corroborated by immunofluorescence results confirming cytoplasmic translocation of E1 on its interaction with P56 (IFIT1). |
complete | |||
| GO:0045071 |
negative regulation of viral genome replication |
IMP: Inferred from Mutant Phenotype |
P |
Figure 5B and 5D. Ablation of P56 (IFIT1) expression by siRNA or shRNAi for P56 substantially alleviating the HPV DNA replication inhibition. |
complete | |||
| GO:0051097 |
negative regulation of helicase activity |
IDA: Inferred from Direct Assay |
P |
Figure 7A and 7B confirm that P56 (IFIT1) inhibits the helicase activity of E1. |
complete | |||
| GO:0005488 |
binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0005829 |
cytosol |
Reactome:REACT_25192 |
TAS: Traceable Author Statement |
C |
||||
| GO:0009615 |
response to virus |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0009615 |
response to virus |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0019060 |
intracellular transport of viral proteins in host cell |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:REACT_25229 |
TAS: Traceable Author Statement |
P |
||||
| GO:0032091 |
negative regulation of protein binding |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0045070 |
positive regulation of viral genome replication |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0045071 |
negative regulation of viral genome replication |
IMP: Inferred from Mutant Phenotype |
P |
|||||
| GO:0050688 |
regulation of defense response to virus |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0050689 |
negative regulation of defense response to virus by host |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0051097 |
negative regulation of helicase activity |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0060337 |
type I interferon-mediated signaling pathway |
Reactome:REACT_25162 |
TAS: Traceable Author Statement |
P |
||||
| GO:0071357 |
cellular response to type I interferon |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0071357 |
cellular response to type I interferon |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0071360 |
cellular response to exogenous dsRNA |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0071360 |
cellular response to exogenous dsRNA |
IDA: Inferred from Direct Assay |
P |
| ||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 Terenzi F et al. (2008) Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. EMBO J 27: 3311-21 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Li Y et al. (2009) ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. Proc Natl Acad Sci U S A 106: 7945-50 PubMed GONUTS page
