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HUMAN:IF16
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | IFI16 (synonyms: IFNGIP1) | |
| Protein Name(s) | Gamma-interferon-inducible protein 16
Ifi-16 Interferon-inducible myeloid differentiation transcriptional activator | |
| External Links | ||
| EMBL | M63838 S75433 S75417 S75419 S75421 S75423 S75424 S75426 S75429 S75431 AF208043 AY138863 AB208989 AL359753 AL359753 AL359753 AL359753 AL359753 AL359753 BC017059 AK094968 | |
| IPI | IPI00003443 IPI00217474 IPI00217475 IPI00384836 | |
| PIR | I54501 | |
| RefSeq | NP_001193496.1 NP_005522.2 | |
| UniGene | Hs.380250 | |
| PDB | 2OQ0 3B6Y | |
| PDBsum | 2OQ0 3B6Y | |
| ProteinModelPortal | Q16666 | |
| SMR | Q16666 | |
| IntAct | Q16666 | |
| MINT | MINT-1781545 | |
| STRING | Q16666 | |
| PhosphoSite | Q16666 | |
| PRIDE | Q16666 | |
| Ensembl | ENST00000295809 | |
| GeneID | 3428 | |
| KEGG | hsa:3428 | |
| NMPDR | fig|9606.3.peg.2390 | |
| UCSC | uc001ftg.1 | |
| CTD | 3428 | |
| GeneCards | GC01P130336 | |
| HGNC | HGNC:5395 | |
| HPA | CAB016293 HPA002134 | |
| MIM | 147586 | |
| neXtProt | NX_Q16666 | |
| PharmGKB | PA29642 | |
| eggNOG | prNOG13079 | |
| GeneTree | ENSGT00390000013296 | |
| HOVERGEN | HBG006122 | |
| InParanoid | Q16666 | |
| OMA | MTSIGPA | |
| PhylomeDB | Q16666 | |
| NextBio | 13516 | |
| ArrayExpress | Q16666 | |
| Bgee | Q16666 | |
| Genevestigator | Q16666 | |
| GermOnline | ENSG00000163565 | |
| GO | GO:0005737 GO:0016607 GO:0005730 GO:0003690 GO:0005515 GO:0008283 GO:0042771 GO:0030224 GO:0045892 GO:0009615 GO:0006351 | |
| InterPro | IPR011029 IPR004021 IPR012340 IPR004020 | |
| Gene3D | G3DSA:2.40.50.140 | |
| Pfam | PF02760 PF02758 | |
| SUPFAM | SSF47986 | |
| PROSITE | PS50824 PS50834 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003690 |
double-stranded DNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005654 |
nucleoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005730 |
nucleolus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005730 |
nucleolus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0008283 |
cell proliferation |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0009615 |
response to virus |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0016607 |
nuclear speck |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0030097 |
hemopoiesis |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0030099 |
myeloid cell differentiation |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0030224 |
monocyte differentiation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0042771 |
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043027 |
caspase inhibitor activity |
IMP: Inferred from Mutant Phenotype |
F |
Fig. 4, Fig. 5, and Fig. 6 |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Dawson MJ & Trapani JA (1995) IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. J Cell Biochem 57: 39-51 PubMed GONUTS page
- ↑ Unterholzner L et al. (2010) IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 11: 997-1004 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
- ↑ 4.0 4.1 Bürckstümmer T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 10: 266-72 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Aglipay JA et al. (2003) A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 22: 8931-8 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Dawson MJ et al. (1998) The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations. J Leukoc Biol 64: 546-54 PubMed GONUTS page
- ↑ Johnstone RW et al. (1998) The human interferon-inducible protein, IFI 16, is a repressor of transcription. J Biol Chem 273: 17172-7 PubMed GONUTS page
- ↑ Veeranki S et al. (2011) IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes. PLoS One 6: e27040 PubMed GONUTS page
