HUMAN:IDE

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	IDE
Protein Name(s)	Insulin-degrading enzyme Abeta-degrading protease Insulin protease Insulinase Insulysin
External Links
UniProt Identifier	IDE_HUMAN
UniProt Accessions	P14735, D3DR35, Q5T5N2,
EMBL	M21188, AL356128, CH471066, CH471066, BC096336, BC096337, BC096339,
PIR	A40119,
RefSeq	NP_004960.2,
PDB	2G47, 2G48, 2G49, 2G54, 2G56, 2JBU, 2JG4, 2WBY, 2WC0, 2WK3, 3CWW, 3E4A, 3E4Z, 3E50, 3H44, 3HGZ, 3N56, 3N57, 3OFI,
Ensembl	ENST00000265986,
Pfam	PF00675, PF05193,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011237	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011249	F
	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001431	F
	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007863	F
	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011765	F
	GO:0004222	metalloendopeptidase activity	PMID:17613531^[1]	IDA: Inferred from Direct Assay		F
	GO:0004871	signal transducer activity	PMID:2293021^[2]	TAS: Traceable Author Statement		F
	GO:0004871	signal transducer activity	PMID:3059494^[3]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:17715127^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y6E7	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005524	ATP binding	PMID:17613531^[1]	IDA: Inferred from Direct Assay		F
	GO:0005615	extracellular space	PMID:9830016^[5]	TAS: Traceable Author Statement		C
	GO:0005625	soluble fraction	PMID:9830016^[5]	TAS: Traceable Author Statement		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005777	peroxisome	PMID:8425612^[6]	TAS: Traceable Author Statement		C
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001431	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007863	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011765	P
	GO:0006508	proteolysis	PMID:9830016^[5]	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	PMID:2293021^[2]	NAS: Non-traceable Author Statement		P
	GO:0007165	signal transduction	PMID:2293021^[2]	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	PMID:3059494^[3]	TAS: Traceable Author Statement		P
	GO:0007548	sex differentiation	PMID:8425612^[6]	TAS: Traceable Author Statement		P
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0008237	metallopeptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0482	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007863	F
	GO:0008270	zinc ion binding	PMID:17613531^[1]	IDA: Inferred from Direct Assay		F
	GO:0009986	cell surface	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0310	C
	GO:0010815	bradykinin catabolic process	PMID:17613531^[1]	IDA: Inferred from Direct Assay		P
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0042803	protein homodimerization activity	PMID:17613531^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P14735	F
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P
	GO:0046872	metal ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011237	F
	GO:0046872	metal ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011249	F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0050435	beta-amyloid metabolic process	PMID:17613531^[1]	IDA: Inferred from Direct Assay		P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0001540	beta-amyloid binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011237	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011249	F
	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001431	F
	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007863	F
	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011765	F
	GO:0004222	metalloendopeptidase activity	PMID:17613531^[1]	IDA: Inferred from Direct Assay		F
	GO:0004871	signal transducer activity	PMID:2293021^[2]	TAS: Traceable Author Statement		F
	GO:0004871	signal transducer activity	PMID:3059494^[3]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:17715127^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y6E7	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005524	ATP binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	F
	GO:0005524	ATP binding	PMID:17613531^[1]	IDA: Inferred from Direct Assay		F
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	C
	GO:0005615	extracellular space	PMID:9830016^[5]	TAS: Traceable Author Statement		C
	GO:0005625	soluble fraction	PMID:9830016^[5]	TAS: Traceable Author Statement		C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005777	peroxisome	PMID:8425612^[6]	TAS: Traceable Author Statement		C
	GO:0005782	peroxisomal matrix	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	C
	GO:0006200	ATP catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001431	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007863	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011765	P
	GO:0006508	proteolysis	PMID:9830016^[5]	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	PMID:2293021^[2]	NAS: Non-traceable Author Statement		P
	GO:0007165	signal transduction	PMID:2293021^[2]	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	PMID:3059494^[3]	TAS: Traceable Author Statement		P
	GO:0007548	sex differentiation	PMID:8425612^[6]	TAS: Traceable Author Statement		P
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0008237	metallopeptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0482	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007863	F
	GO:0008270	zinc ion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	F
	GO:0008270	zinc ion binding	PMID:17613531^[1]	IDA: Inferred from Direct Assay		F
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	C
	GO:0009986	cell surface	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0310	C
	GO:0010815	bradykinin catabolic process	PMID:17613531^[1]	IDA: Inferred from Direct Assay		P
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016887	ATPase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	F
	GO:0017046	peptide hormone binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	F
	GO:0031597	cytosolic proteasome complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	C
	GO:0031626	beta-endorphin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	F
	GO:0042447	hormone catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	P
	GO:0042803	protein homodimerization activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	F
	GO:0042803	protein homodimerization activity	PMID:17613531^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P14735	F
	GO:0043559	insulin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	F
	GO:0044257	cellular protein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	P
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P
	GO:0045861	negative regulation of proteolysis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	P
	GO:0046872	metal ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011237	F
	GO:0046872	metal ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011249	F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0050435	beta-amyloid metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	P
	GO:0050435	beta-amyloid metabolic process	PMID:17613531^[1]	IDA: Inferred from Direct Assay		P
	GO:0051289	protein homotetramerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	P
	GO:0051291	protein heterooligomerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	P
	GO:0051603	proteolysis involved in cellular protein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000023342	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Im H et al. (2007) Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem 282: 25453-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Affholter JA et al. (1990) Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. Mol Endocrinol 4: 1125-35 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Affholter JA et al. (1988) Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III. Science 242: 1415-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Ahuja N et al. (2007) Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem 282: 33583-92 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Qiu WQ et al. (1998) Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem 273: 32730-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Baumeister H et al. (1993) The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts. FEBS Lett 317: 250-4 PubMed GONUTS page

[PMID:17613531-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Im H et al. (2007) Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem 282: 25453-63 PubMed GONUTS page

[PMID:2293021-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Affholter JA et al. (1990) Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. Mol Endocrinol 4: 1125-35 PubMed GONUTS page

[PMID:3059494-2] 3.0 ^3.1 ^3.2 ^3.3 Affholter JA et al. (1988) Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III. Science 242: 1415-8 PubMed GONUTS page

[PMID:17715127-3] 4.0 ^4.1 Ahuja N et al. (2007) Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem 282: 33583-92 PubMed GONUTS page

[PMID:9830016-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Qiu WQ et al. (1998) Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem 273: 32730-8 PubMed GONUTS page

[PMID:8425612-5] 6.0 ^6.1 ^6.2 ^6.3 Baumeister H et al. (1993) The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts. FEBS Lett 317: 250-4 PubMed GONUTS page

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HUMAN:IDE

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