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HUMAN:HPT
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (taxon:9606) | |
| Gene Name(s) | HP | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | HPT_HUMAN | |
| UniProt Accessions | P00738, B0AZL5, P00737, Q0VAC4, Q2PP15, Q3B7J0, Q6LBY9, Q9UC67, | |
| EMBL | K00422, K01763, L29394, X00637, X01793, X01786, X02206, X01789, X01791, M10935, M69197, AK314700, DQ314870, BC107587, BC121125, M13192, AC004682, X00606, | |
| PIR | A92532, A93521, | |
| RefSeq | NP_001119574.1, NP_005134.1, | |
| IntAct | P00738, | |
| Ensembl | ENST00000355906, | |
| Pfam | PF00089, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005576 |
extracellular region |
NAS: Non-traceable Author Statement |
C |
Source: UniProtKB |
||||
| GO:0030492 |
hemoglobin binding |
IEA: Inferred from Electronic Annotation |
F |
Source: UniProtKB-KW |
||||
| GO:0004252 |
serine-type endopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
Source: InterPro |
||||
| GO:0006879 |
cellular iron ion homeostasis |
NAS: Non-traceable Author Statement |
P |
Source: UniProtKB |
||||
| GO:0006952 |
defense response |
TAS: Traceable Author Statement |
P |
Source: ProtInc |
||||
| GO:0006508 |
proteolysis |
IEA: Inferred from Electronic Annotation |
P |
Source: InterPro |
||||
| GO:0030492 |
hemoglobin binding |
IDA: Inferred from Direct Assay |
F |
Fig 2 shows haemoglobin-haptoglobin complexes and how EPR signal varies compared to pure haemoglobin. |
complete | |||
| GO:0031838 |
haptoglobin-hemoglobin complex |
IDA: Inferred from Direct Assay |
C |
Fig 2 shows haemoglobin-haptoglobin complexes and how EPR signal varies compared to pure haemoglobin. |
complete | |||
|
Contributes to |
GO:0004601 |
peroxidase activity |
IDA: Inferred from Direct Assay |
F |
Fig 5 shows positive peroxidase activity of haemoglobin-haptoglobin complexes. |
complete | ||
|
Contributes to |
GO:0042542 |
response to hydrogen peroxide |
IDA: Inferred from Direct Assay |
P |
Fig 3: large MW aggregates can be seen after addition of hydrogen peroxide when both haemoglobin and haptoglobin are present. |
complete | ||
| GO:0003824 |
catalytic activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0004252 |
serine-type endopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0004252 |
serine-type endopeptidase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0243 |
C |
||||
| GO:0005576 |
extracellular region |
NAS: Non-traceable Author Statement |
C |
|||||
| GO:0006508 |
proteolysis |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006508 |
proteolysis |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006879 |
cellular iron ion homeostasis |
NAS: Non-traceable Author Statement |
P |
|||||
| GO:0006952 |
defense response |
TAS: Traceable Author Statement |
P |
|||||
| GO:0010942 |
positive regulation of cell death |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0030492 |
hemoglobin binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0030492 |
hemoglobin binding |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0031838 |
haptoglobin-hemoglobin complex |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0042542 |
response to hydrogen peroxide |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0051354 |
negative regulation of oxidoreductase activity |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:2000296 |
negative regulation of hydrogen peroxide catabolic process |
IDA: Inferred from Direct Assay |
P |
| ||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Kapralov A et al. (2009) Peroxidase activity of hemoglobin-haptoglobin complexes: covalent aggregation and oxidative stress in plasma and macrophages. J Biol Chem 284: 30395-407 PubMed GONUTS page
- ↑ Anderson NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 3: 311-26 PubMed GONUTS page
- ↑ Eaton JW et al. (1982) Haptoglobin: a natural bacteriostat. Science 215: 691-3 PubMed GONUTS page
