HUMAN:HERC2

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	HERC2
Protein Name(s)	E3 ubiquitin-protein ligase HERC2 HECT domain and RCC1-like domain-containing protein 2
External Links
UniProt Identifier	HERC2_HUMAN
UniProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1,
EMBL	AF071172, AC091304, AC126332, AC135329, AF224243, AF224242, AF224245, AF224244, AF224249, AF224246, AF224247, AF224248, AF224251, AF224250, AF224255, AF224254, AF224252, AF224253, AF224257, AF224256, AF225401, AF225400, AF225404, AF225402, AF225403, AF225407, AF225405, AF225406, AF225409, AF225408,
RefSeq	NP_004658.3,
PDB	2KEO, 3KCI,
IntAct	O95714,
Ensembl	ENST00000261609,
Pfam	PF03256, PF11515, PF00173, PF00632, PF06701, PF00415, PF00569,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0046872	metal ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010606	F
	GO:0016567	protein ubiquitination	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010606	P
	GO:0006886	intracellular protein transport	PMID:9949213^[1]	NAS: Non-traceable Author Statement		P
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0007283	spermatogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000075579	P
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0006464	protein modification process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	P
	GO:0030071	regulation of mitotic metaphase/anaphase transition	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004939	P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P
	GO:0016874	ligase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0436	F
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0005515	protein binding	PMID:17353931^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UJU6	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005515	protein binding	PMID:17353931^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O75352	F
	GO:0005743	mitochondrial inner membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000075579	C
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000433	F
	GO:0004842	ubiquitin-protein ligase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010606	F
	GO:0005680	anaphase-promoting complex	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004939	C
	GO:0016881	acid-amino acid ligase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	F
	GO:0020037	heme binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001199	F
	GO:0005085	guanyl-nucleotide exchange factor activity	PMID:9949213^[1]	NAS: Non-traceable Author Statement		F
	GO:0004842	ubiquitin-protein ligase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010606	F
	GO:0004842	ubiquitin-protein ligase activity	GO_REF:0000033		PANTHER:PTHR11254_AN0	F
	GO:0004842	ubiquitin-protein ligase activity	PMID:20304803^[3]	IDA: Inferred from Direct Assay		F
	GO:0005085	guanyl-nucleotide exchange factor activity	PMID:9949213^[1]	NAS: Non-traceable Author Statement		F
	GO:0005515	protein binding	PMID:17353931^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O75352	F
	GO:0005515	protein binding	PMID:17353931^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UJU6	F
	GO:0005515	protein binding	PMID:20023648^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O76064	F
	GO:0005515	protein binding	PMID:20304803^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P23025	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	C
	GO:0005622	intracellular	PMID:9949213^[1]	NAS: Non-traceable Author Statement		C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:20304803^[3]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:20304803^[3]	IDA: Inferred from Direct Assay		C
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P
	GO:0006281	DNA repair	PMID:20023648^[4]	IDA: Inferred from Direct Assay		P
	GO:0006464	protein modification process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	P
	GO:0006886	intracellular protein transport	PMID:9949213^[1]	NAS: Non-traceable Author Statement		P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000433	F
	GO:0016567	protein ubiquitination	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010606	P
	GO:0016567	protein ubiquitination	PMID:20304803^[3]	IDA: Inferred from Direct Assay		P
	GO:0016874	ligase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0436	F
	GO:0016881	acid-amino acid ligase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000569	F
	GO:0020037	heme binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001199	F
	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	GO_REF:0000033		PANTHER:PTHR11254_AN0	P
	GO:0046872	metal ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010606	F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Ji Y et al. (1999) The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities. Hum Mol Genet 8: 533-42 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Kang TH et al. (2010) Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase. Proc Natl Acad Sci U S A 107: 4890-5 PubMed GONUTS page
↑ ^4.0 ^4.1 Bekker-Jensen S et al. (2010) HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nat Cell Biol 12: 80-6; sup pp 1-12 PubMed GONUTS page

[PMID:9949213-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Ji Y et al. (1999) The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities. Hum Mol Genet 8: 533-42 PubMed GONUTS page

[PMID:17353931-1] 2.0 ^2.1 ^2.2 ^2.3 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page

[PMID:20304803-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Kang TH et al. (2010) Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase. Proc Natl Acad Sci U S A 107: 4890-5 PubMed GONUTS page

[PMID:20023648-3] 4.0 ^4.1 Bekker-Jensen S et al. (2010) HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nat Cell Biol 12: 80-6; sup pp 1-12 PubMed GONUTS page

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HUMAN:HERC2

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