HUMAN:GRIA1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	GRIA1 ( synonyms: GLUH1, GLUR1 )
Protein Name(s)	Glutamate receptor 1 GluR-1 AMPA-selective glutamate receptor 1 GluR-A GluR-K1 Glutamate receptor ionotropic, AMPA 1 GluA1
External Links
UniProt Identifier	GRIA1_HUMAN
UniProt Accessions	P42261, D3DQI4, Q2NKM6,
EMBL	M64752, X58633, M81886, CH471062, CH471062, BC111734,
PIR	A40222, A41273, S25852, S38723,
RefSeq	NP_000818.2, NP_001107655.1,
Ensembl	ENST00000285900,
Pfam	PF01094, PF00060, PF10613,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0030054	cell junction		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-KW
	GO:0030666	endocytic vesicle membrane		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0005789	endoplasmic reticulum membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0045211	postsynaptic membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005234	extracellular-glutamate-gated ion channel a...		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0015277	kainate selective glutamate receptor activity		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0007268	synaptic transmission		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0004872	receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001508	F
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001320	F
	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019594	F
	GO:0004971	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	PMID:20805473^[1]	IDA: Inferred from Direct Assay		F
	GO:0004971	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	PMID:21172611^[2]	IDA: Inferred from Direct Assay		F
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001508	F
	GO:0005216	ion channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0407	F
	GO:0005234	extracellular-glutamate-gated ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001320	F
	GO:0005234	extracellular-glutamate-gated ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001508	F
	GO:0005234	extracellular-glutamate-gated ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019594	F
	GO:0005515	protein binding	PMID:20805473^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q6PI25	F
	GO:0005515	protein binding	PMID:20805473^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y698	F
	GO:0005624	membrane fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091731	C
	GO:0005783	endoplasmic reticulum	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0256	C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0097	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:1311100^[3]	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_18258	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_18296	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_18308	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_18320	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_18330	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_18341	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_18378	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_18393	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_18434	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_20500	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_20569	TAS: Traceable Author Statement		C
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001508	P
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P
	GO:0007165	signal transduction	PMID:1311100^[3]	TAS: Traceable Author Statement		P
	GO:0007268	synaptic transmission	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091731	P
	GO:0007268	synaptic transmission	PMID:1311100^[3]	TAS: Traceable Author Statement		P
	GO:0007268	synaptic transmission	Reactome:REACT_13477	TAS: Traceable Author Statement		P
	GO:0007268	synaptic transmission	Reactome:REACT_13685	TAS: Traceable Author Statement		P
	GO:0008066	glutamate receptor activity	PMID:1320959^[4]	TAS: Traceable Author Statement		F
	GO:0014069	postsynaptic density	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0297	C
	GO:0014069	postsynaptic density	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23818	C
	GO:0015277	kainate selective glutamate receptor activity	PMID:1311100^[3]	TAS: Traceable Author Statement		F
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001320	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001508	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019594	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C
	GO:0030165	PDZ domain binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23818	F
	GO:0030425	dendrite	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0283	C
	GO:0030425	dendrite	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23818	C
	GO:0030666	endocytic vesicle membrane	Reactome:REACT_18308	TAS: Traceable Author Statement		C
	GO:0030666	endocytic vesicle membrane	Reactome:REACT_18330	TAS: Traceable Author Statement		C
	GO:0030666	endocytic vesicle membrane	Reactome:REACT_18393	TAS: Traceable Author Statement		C
	GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000091731	C
	GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P19490	C
	GO:0042995	cell projection	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0966	C
	GO:0043025	neuronal cell body	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23818	C
	GO:0043197	dendritic spine	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0284	C
	GO:0043197	dendritic spine	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23818	C
	GO:0044309	neuron spine	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23818	C
	GO:0045202	synapse	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0770	C
	GO:0045211	postsynaptic membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0628	C
	GO:0045211	postsynaptic membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0219	C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Shi Y et al. (2010) Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Proc Natl Acad Sci U S A 107: 16315-9 PubMed GONUTS page
↑ Kato AS et al. (2010) Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron 68: 1082-96 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Sun W et al. (1992) Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. Proc Natl Acad Sci U S A 89: 1443-7 PubMed GONUTS page
↑ Potier MC et al. (1992) The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. DNA Seq 2: 211-8 PubMed GONUTS page

[PMID:20805473-0] 1.0 ^1.1 ^1.2 Shi Y et al. (2010) Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Proc Natl Acad Sci U S A 107: 16315-9 PubMed GONUTS page

[PMID:21172611-1] Kato AS et al. (2010) Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron 68: 1082-96 PubMed GONUTS page

[PMID:1311100-2] 3.0 ^3.1 ^3.2 ^3.3 Sun W et al. (1992) Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. Proc Natl Acad Sci U S A 89: 1443-7 PubMed GONUTS page

[PMID:1320959-3] Potier MC et al. (1992) The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. DNA Seq 2: 211-8 PubMed GONUTS page

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HUMAN:GRIA1

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