HUMAN:GRDN

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	CCDC88A ( synonyms: APE, GRDN, KIAA1212 )
Protein Name(s)	Girdin Akt phosphorylation enhancer APE Coiled-coil domain-containing protein 88A G alpha-interacting vesicle-associated protein GIV Girders of actin filament Hook-related protein 1 HkRP1
External Links
UniProt Identifier	GRDN_HUMAN
UniProt Accessions	Q3V6T2, A1IGE7, Q53SF1, Q581G3, Q5HYD0, Q7Z339, Q7Z3C5,
EMBL	AB201172, AB125644, AC019198, AC092176, AC012358, BC132736, BX537985, BX538154, BX648138,
RefSeq	NP_001129069.1, NP_060554.3,
IntAct	Q3V6T2,
Ensembl	ENST00000436346,
Pfam	PF05622,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016023	cytoplasmic membrane-bounded vesicle		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005829	cytosol		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005783	endoplasmic reticulum		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005794	Golgi apparatus		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0030027	lamellipodium		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005886	plasma membrane		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0003779	actin binding	PMID:16139227^[1]	IDA: Inferred from Direct Assay		F	Figure 3.	complete
	GO:0008017	microtubule binding		ISS: Inferred from Sequence or Structural Similarity		F	Source: UniProtKB
	GO:0035091	phosphoinositide binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0042803	protein homodimerization activity		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0043422	protein kinase B binding	PMID:16139227^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P31749	F	Figure 2.	complete
	GO:0032148	activation of protein kinase B activity		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0016477	cell migration		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0016044	cellular membrane organization		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0006260	DNA replication		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0030032	lamellipodium assembly		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0032956	regulation of actin cytoskeleton organization		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0042127	regulation of cell proliferation		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0006275	regulation of DNA replication		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0010975	regulation of neuron projection development		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0001932	regulation of protein amino acid phosphoryl...		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0031929	TOR signaling cascade		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008636	P
	GO:0001932	regulation of protein phosphorylation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q5SNZ0	P
	GO:0003779	actin binding	PMID:16139227^[1]	IDA: Inferred from Direct Assay		F
	GO:0005737	cytoplasm	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008636	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005783	endoplasmic reticulum	PMID:15882442^[2]	IDA: Inferred from Direct Assay		C
	GO:0005794	Golgi apparatus	PMID:15882442^[2]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0091	C
	GO:0005829	cytosol	PMID:15749703^[3]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:15882442^[2]	IDA: Inferred from Direct Assay		C
	GO:0006260	DNA replication	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0235	P
	GO:0006275	regulation of DNA replication	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q5SNZ0	P
	GO:0007399	nervous system development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0524	P
	GO:0008017	microtubule binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008636	F
	GO:0008017	microtubule binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q5SNZ0	F
	GO:0010975	regulation of neuron projection development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q5SNZ0	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016020	membrane	PMID:15749703^[3]	IDA: Inferred from Direct Assay		C
	GO:0016020	membrane	PMID:15882442^[2]	IDA: Inferred from Direct Assay		C
	GO:0016023	cytoplasmic membrane-bounded vesicle	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0088	C
	GO:0016044	cellular membrane organization	PMID:15882442^[2]	IDA: Inferred from Direct Assay		P
	GO:0016477	cell migration	PMID:16139227^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0030027	lamellipodium	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0291	C
	GO:0030027	lamellipodium	PMID:16139227^[1]	IDA: Inferred from Direct Assay		C
	GO:0030032	lamellipodium assembly	PMID:16139227^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0031410	cytoplasmic vesicle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0968	C
	GO:0031410	cytoplasmic vesicle	PMID:15882442^[2]	IDA: Inferred from Direct Assay		C
	GO:0031929	TOR signaling cascade	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q5SNZ0	P
	GO:0032148	activation of protein kinase B activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q5SNZ0	P
	GO:0032956	regulation of actin cytoskeleton organization	PMID:16139227^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0035091	phosphatidylinositol binding	PMID:16139227^[1]	IDA: Inferred from Direct Assay		F
	GO:0042127	regulation of cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q5SNZ0	P
	GO:0042803	protein homodimerization activity	PMID:16139227^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q3V6T2	F
	GO:0042995	cell projection	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0966	C
	GO:0043422	protein kinase B binding	PMID:16139227^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P31749	F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Enomoto A et al. (2005) Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell 9: 389-402 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Simpson F et al. (2005) A novel hook-related protein family and the characterization of hook-related protein 1. Traffic 6: 442-58 PubMed GONUTS page
↑ ^3.0 ^3.1 Le-Niculescu H et al. (2005) Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J Biol Chem 280: 22012-20 PubMed GONUTS page

[PMID:16139227-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Enomoto A et al. (2005) Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell 9: 389-402 PubMed GONUTS page

[PMID:15882442-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Simpson F et al. (2005) A novel hook-related protein family and the characterization of hook-related protein 1. Traffic 6: 442-58 PubMed GONUTS page

[PMID:15749703-2] 3.0 ^3.1 Le-Niculescu H et al. (2005) Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J Biol Chem 280: 22012-20 PubMed GONUTS page

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HUMAN:GRDN

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