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HUMAN:GP143
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | GPR143 (synonyms: OA1) | |
| Protein Name(s) | G-protein coupled receptor 143
Ocular albinism type 1 protein | |
| External Links | ||
| EMBL | Z48804 AC003036 AC090481 CH471074 BC068977 | |
| IPI | IPI00218565 | |
| RefSeq | NP_000264.2 | |
| UniGene | Hs.74124 | |
| ProteinModelPortal | P51810 | |
| IntAct | P51810 | |
| STRING | P51810 | |
| PhosphoSite | P51810 | |
| PRIDE | P51810 | |
| Ensembl | ENST00000380929 ENST00000467482 | |
| GeneID | 4935 | |
| KEGG | hsa:4935 | |
| UCSC | uc004cst.1 | |
| CTD | 4935 | |
| GeneCards | GC0XM007525 | |
| H-InvDB | HIX0056224 | |
| HGNC | HGNC:20145 | |
| MIM | 300500 300808 300814 | |
| neXtProt | NX_P51810 | |
| Orphanet | 651 54 | |
| PharmGKB | PA31872 | |
| eggNOG | prNOG17029 | |
| GeneTree | ENSGT00390000016722 | |
| HOGENOM | HBG715024 | |
| HOVERGEN | HBG051784 | |
| InParanoid | P51810 | |
| OrthoDB | EOG42RD7J | |
| NextBio | 19011 | |
| ArrayExpress | P51810 | |
| Bgee | P51810 | |
| CleanEx | HS_GPR143 | |
| Genevestigator | P51810 | |
| GermOnline | ENSG00000101850 | |
| GO | GO:0016324 GO:0005794 GO:0016021 GO:0005765 GO:0033162 GO:0005624 GO:0035240 GO:0035643 GO:0005515 GO:0072545 GO:0035584 GO:0006726 GO:0032438 GO:0032402 GO:0048015 GO:0050848 GO:0007601 | |
| InterPro | IPR001414 | |
| KO | K08470 | |
| Pfam | PF02101 | |
| PRINTS | PR00965 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004871 |
signal transducer activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004930 |
G-protein coupled receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004930 |
G-protein coupled receptor activity |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0004930 |
G-protein coupled receptor activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005624 |
membrane fraction |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005764 |
lysosome |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005765 |
lysosomal membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0157 |
C |
Seeded From UniProt |
|||
| GO:0005765 |
lysosomal membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005794 |
Golgi apparatus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005794 |
Golgi apparatus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0132 |
C |
Seeded From UniProt |
|||
| GO:0005794 |
Golgi apparatus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006726 |
eye pigment biosynthetic process |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007165 |
signal transduction |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007165 |
signal transduction |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0007601 |
visual perception |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0016324 |
apical plasma membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0015 |
C |
Seeded From UniProt |
|||
| GO:0016324 |
apical plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0032400 |
melanosome localization |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026383 |
P |
Seeded From UniProt |
|||
| GO:0032400 |
melanosome localization |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0032400 |
melanosome localization |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0032402 |
melanosome transport |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026383 |
P |
Seeded From UniProt |
|||
| GO:0032402 |
melanosome transport |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0032438 |
melanosome organization |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026383 |
P |
Seeded From UniProt |
|||
| GO:0032438 |
melanosome organization |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0033162 |
melanosome membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0160 |
C |
Seeded From UniProt |
|||
| GO:0033162 |
melanosome membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0035240 |
dopamine binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0035584 |
calcium-mediated signaling using intracellular calcium source |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0035643 |
L-DOPA receptor activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0042470 |
melanosome |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0048015 |
phosphatidylinositol-mediated signaling |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0050848 |
regulation of calcium-mediated signaling |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0072544 |
L-DOPA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0072545 |
tyrosine binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0006726 |
IMP: Inferred from Mutant Phenotype |
Table 1, Figure 1 through Figure 5 |
complete | |||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Schiaffino MV et al. (1999) Ocular albinism: evidence for a defect in an intracellular signal transduction system. Nat Genet 23: 108-12 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Innamorati G et al. (2006) The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor. Pigment Cell Res 19: 125-35 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Giordano F et al. (2009) The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition. Hum Mol Genet 18: 4530-45 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Bassi MT et al. (1995) Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome. Nat Genet 10: 13-9 PubMed GONUTS page
- ↑ 5.0 5.1 Piccirillo R et al. (2006) An unconventional dileucine-based motif and a novel cytosolic motif are required for the lysosomal and melanosomal targeting of OA1. J Cell Sci 119: 2003-14 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Lopez VM et al. (2008) L-DOPA is an endogenous ligand for OA1. PLoS Biol 6: e236 PubMed GONUTS page
- ↑ Mayeur H et al. (2006) Eight previously unidentified mutations found in the OA1 ocular albinism gene. BMC Med Genet 7: 41 PubMed GONUTS page
