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HUMAN:GLUC

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Contents

Species (Taxon ID) Homo sapiens (Human). ([1])
Gene Name(s) GCG
Protein Name(s) Glucagon

Glicentin Glicentin-related polypeptide GRPP Oxyntomodulin OXM OXY Glucagon Glucagon-like peptide 1 GLP-1 Glucagon-like peptide 1(7-37) GLP-1(7-37) Glucagon-like peptide 1(7-36) GLP-1(7-36) Glucagon-like peptide 2 GLP-2

External Links
EMBL J04040
X03991
V01515
BT006813
AC007750
BC005278
IPI IPI00744153
PIR A24377
RefSeq NP_002045.1
UniGene Hs.516494
PDB 1BH0
1D0R
1NAU
2G49
2L63
2L64
3IOL
PDBsum 1BH0
1D0R
1NAU
2G49
2L63
2L64
3IOL
ProteinModelPortal P01275
SMR P01275
DIP DIP-46470N
STRING P01275
PhosphoSite P01275
PRIDE P01275
Ensembl ENST00000375497
ENST00000418842
GeneID 2641
KEGG hsa:2641
UCSC uc002ucc.1
CTD 2641
GeneCards GC02M154881
H-InvDB HIX0002547
HGNC HGNC:4191
HPA CAB000040
MIM 138030
neXtProt NX_P01275
PharmGKB PA28606
eggNOG prNOG13501
GeneTree ENSGT00390000005372
HOVERGEN HBG003010
OrthoDB EOG40K818
PhylomeDB P01275
Pathway_Interaction_DB hnf3apathway
Reactome REACT_111102
REACT_111217
DrugBank DB01276
DB00692
NextBio 10412
PMAP-CutDB P01275
ArrayExpress P01275
Bgee P01275
CleanEx HS_GCG
Genevestigator P01275
GermOnline ENSG00000115263
GO GO:0005788
GO:0005886
GO:0005625
GO:0030141
GO:0005179
GO:0008283
GO:0071377
GO:0006112
GO:0007631
InterPro IPR015550
IPR000532
KO K05259
PANTHER PTHR11418
Pfam PF00123
PRINTS PR00275
SMART SM00070
PROSITE PS00260

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005102

receptor binding

PMID:9990065[1]

TAS: Traceable Author Statement

F

Seeded From UniProt

GO:0005179

hormone activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000532

F

Seeded From UniProt

GO:0005179

hormone activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0372

F

Seeded From UniProt

GO:0005179

hormone activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000007356

F

Seeded From UniProt

GO:0005576

extracellular region

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000532

C

Seeded From UniProt

GO:0005576

extracellular region

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0964

C

Seeded From UniProt

GO:0005576

extracellular region

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0243

C

Seeded From UniProt

GO:0005576

extracellular region

Reactome:REACT_15291

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005576

extracellular region

Reactome:REACT_156

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005576

extracellular region

Reactome:REACT_17008

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005576

extracellular region

Reactome:REACT_18260

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005576

extracellular region

Reactome:REACT_18322

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005576

extracellular region

Reactome:REACT_22110

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005576

extracellular region

Reactome:REACT_22234

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005576

extracellular region

Reactome:REACT_22263

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005576

extracellular region

Reactome:REACT_22268

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005576

extracellular region

Reactome:REACT_22436

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005576

extracellular region

Reactome:REACT_23859

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005576

extracellular region

Reactome:REACT_24006

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005615

extracellular space

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

C

Seeded From UniProt

GO:0005615

extracellular space

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000007356

C

Seeded From UniProt

GO:0005625

soluble fraction

PMID:10861272[2]

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

C

Seeded From UniProt

GO:0005788

endoplasmic reticulum lumen

Reactome:REACT_23848

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005788

endoplasmic reticulum lumen

Reactome:REACT_24009

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_17008

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_18260

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_22234

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_22268

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0006112

energy reserve metabolic process

Reactome:REACT_1505

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0006916

anti-apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

P

Seeded From UniProt

GO:0007165

signal transduction

PMID:7929237[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007186

G-protein coupled receptor signaling pathway

PMID:9990065[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0007188

G-protein signaling, coupled to cAMP nucleotide second messenger

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000007356

P

Seeded From UniProt

GO:0007631

feeding behavior

PMID:8538742[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0008283

cell proliferation

PMID:10861272[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0010737

protein kinase A signaling cascade

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

P

Seeded From UniProt

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

P

Seeded From UniProt

GO:0030141

stored secretory granule

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

C

Seeded From UniProt

GO:0030141

stored secretory granule

Reactome:REACT_23848

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0030141

stored secretory granule

Reactome:REACT_24006

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0030819

positive regulation of cAMP biosynthetic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

P

Seeded From UniProt

GO:0031769

glucagon receptor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000007356

F

Seeded From UniProt

GO:0032092

positive regulation of protein binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

P

Seeded From UniProt

GO:0032099

negative regulation of appetite

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000007356

P

Seeded From UniProt

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

P

Seeded From UniProt

GO:0035774

positive regulation of insulin secretion involved in cellular response to glucose stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

P

Seeded From UniProt

GO:0045860

positive regulation of protein kinase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

P

Seeded From UniProt

GO:0050796

regulation of insulin secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

P

Seeded From UniProt

GO:0050796

regulation of insulin secretion

Reactome:REACT_18325

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0050796

regulation of insulin secretion

Reactome:REACT_23974

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

P

Seeded From UniProt

GO:0071377

cellular response to glucagon stimulus

Reactome:REACT_1665

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0090280

positive regulation of calcium ion import

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000099794

P

Seeded From UniProt

GO:0070091

glucagon secretion

PMID:2901414[5]

IEP: Inferred from Expression Pattern

P

Figures 1 and 2.

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Munroe DG et al. (1999) Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. Proc Natl Acad Sci U S A 96: 1569-73 PubMed GONUTS page
  2. ↑ 2.0 2.1 Benjamin MA et al. (2000) Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse. Gut 47: 112-9 PubMed GONUTS page
  3. ↑ Wayman GA et al. (1994) Synergistic activation of the type I adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo. J Biol Chem 269: 25400-5 PubMed GONUTS page
  4. ↑ Turton MD et al. (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379: 69-72 PubMed GONUTS page
  5. ↑ Drucker DJ & Asa S (1988) Glucagon gene expression in vertebrate brain. J Biol Chem 263: 13475-8 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/HUMAN:GLUC"
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