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HUMAN:GLP1R
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | GLP1R | |
| Protein Name(s) | Glucagon-like peptide 1 receptor
GLP-1 receptor GLP-1-R GLP-1R | |
| External Links | ||
| EMBL | U01104 U01157 U01156 L23503 U10037 AB065685 AY439112 AL035690 BC112126 BC113493 U66062 | |
| IPI | IPI00300576 | |
| PIR | I84494 S71624 | |
| RefSeq | NP_002053.3 | |
| UniGene | Hs.389103 | |
| PDB | 3C59 3C5T 3IOL | |
| PDBsum | 3C59 3C5T 3IOL | |
| ProteinModelPortal | P43220 | |
| SMR | P43220 | |
| DIP | DIP-29980N | |
| MINT | MINT-1217566 | |
| STRING | P43220 | |
| PhosphoSite | P43220 | |
| PRIDE | P43220 | |
| Ensembl | ENST00000373256 | |
| GeneID | 2740 | |
| KEGG | hsa:2740 | |
| UCSC | uc003ooj.2 | |
| CTD | 2740 | |
| GeneCards | GC06P038734 | |
| H-InvDB | HIX0200932 | |
| HGNC | HGNC:4324 | |
| MIM | 138032 | |
| neXtProt | NX_P43220 | |
| PharmGKB | PA28725 | |
| eggNOG | prNOG11421 | |
| GeneTree | ENSGT00580000081498 | |
| HOGENOM | HBG447108 | |
| HOVERGEN | HBG008318 | |
| InParanoid | P43220 | |
| OMA | NYWLIIR | |
| OrthoDB | EOG46143W | |
| Reactome | REACT_111102 REACT_111217 | |
| DrugBank | DB01276 DB00040 | |
| NextBio | 10800 | |
| ArrayExpress | P43220 | |
| Bgee | P43220 | |
| CleanEx | HS_GLP1R | |
| Genevestigator | P43220 | |
| GermOnline | ENSG00000112164 | |
| GO | GO:0004967 GO:0006112 | |
| InterPro | IPR017981 IPR001879 IPR003290 IPR003292 IPR000832 IPR017983 | |
| KO | K04581 | |
| PANTHER | PTHR12011:SF20 | |
| Pfam | PF00002 PF02793 | |
| PRINTS | PR01353 PR01355 PR00249 | |
| SMART | SM00008 | |
| PROSITE | PS00649 PS00650 PS50227 PS50261 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001653 |
peptide receptor activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
F |
Seeded From UniProt |
|||
| GO:0004871 |
signal transducer activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004888 |
transmembrane signaling receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004888 |
transmembrane signaling receptor activity |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0004930 |
G-protein coupled receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004930 |
G-protein coupled receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004930 |
G-protein coupled receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004930 |
G-protein coupled receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004967 |
glucagon receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0039 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
Reactome:REACT_17008 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_18260 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_22234 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_22268 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005887 |
integral to plasma membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
C |
Seeded From UniProt |
|||
| GO:0006112 |
energy reserve metabolic process |
Reactome:REACT_1505 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0007165 |
signal transduction |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007166 |
cell surface receptor linked signaling pathway |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007186 |
G-protein coupled receptor signaling pathway |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007189 |
activation of adenylate cyclase activity by G-protein signaling pathway |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0007190 |
activation of adenylate cyclase activity |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007204 |
elevation of cytosolic calcium ion concentration |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0007613 |
memory |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0007631 |
feeding behavior |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0008284 |
positive regulation of cell proliferation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0008306 |
associative learning |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0008528 |
G-protein coupled peptide receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008528 |
G-protein coupled peptide receptor activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
F |
Seeded From UniProt |
|||
| GO:0009749 |
response to glucose stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0017046 |
peptide hormone binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
F |
Seeded From UniProt |
|||
| GO:0019933 |
cAMP-mediated signaling |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0019933 |
cAMP-mediated signaling |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0032024 |
positive regulation of insulin secretion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0043066 |
negative regulation of apoptosis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0043526 |
neuroprotection |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0045334 |
clathrin-coated endocytic vesicle |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
C |
Seeded From UniProt |
|||
| GO:0045597 |
positive regulation of cell differentiation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0045777 |
positive regulation of blood pressure |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0045823 |
positive regulation of heart contraction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0050796 |
regulation of insulin secretion |
Reactome:REACT_18325 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0051209 |
release of sequestered calcium ion into cytosol |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0051929 |
positive regulation of calcium ion transport via voltage-gated calcium channel activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000061009 |
P |
Seeded From UniProt |
|||
| GO:0008528 |
G-protein coupled peptide receptor activity |
IDA: Inferred from Direct Assay |
F |
Shown through an experiment causing mutations, the ECL2 of the GLP-1R plays a large role in GLP-1 peptide-mediated selective signaling and receptor activation. Detailed on pages 3-4 |
complete | |||
| GO:0050796 |
regulation of insulin secretion |
IDA: Inferred from Direct Assay |
P |
GLP-1, which is released from L-cells, utilizes afferent sensory neurons to regulate the release of insulin and glucose. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Thorens B et al. (1993) Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42: 1678-82 PubMed GONUTS page
- ↑ 2.0 2.1 Gromada J et al. (1995) Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release. FEBS Lett 373: 182-6 PubMed GONUTS page
- ↑ Koole C et al. (2012) Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function. J Biol Chem 287: 3659-73 PubMed GONUTS page
- ↑ Schelshorn D et al. (2012) Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation. Mol Pharmacol 81: 309-18 PubMed GONUTS page
