HUMAN:GATA3

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	GATA3
Protein Name(s)	Trans-acting T-cell-specific transcription factor GATA-3 GATA-binding factor 3
External Links
UniProt Identifier	GATA3_HUMAN
UniProt Accessions	P23771, Q5VWG7, Q5VWG8, Q96J16,
EMBL	X58072, X55037, X55122, M69106, AY497006, AL390294, AL390294, CH471072, CH471072, BC003070, BC006793,
PIR	A39794,
RefSeq	NP_001002295.1, NP_002042.1,
Ensembl	ENST00000346208,
Pfam	PF00320,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: LIFEdb
	GO:0071837	HMG box domain binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0043565	sequence-specific DNA binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0003700	sequence-specific DNA binding transcription factor activity		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0008134	transcription factor binding		IPI: Inferred from Physical Interaction		F	Source: BHF-UCL
	GO:0008270	zinc ion binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0009653	anatomical structure morphogenesis		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0006952	defense response		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0006355	regulation of transcription, DNA-dependent		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0043627	response to estrogen stimulus		IEP: Inferred from Expression Pattern		P	Source: UniProtKB
	GO:0070888	E-box binding	PMID:20855495^[1]	IDA: Inferred from Direct Assay		F	using oligonucleotides that cover all E-boxes and GATA binding sites present in the −875/−570 human NKX3.1 promoter region, we found that TAL1 and GATA-3 can bind an E-box located at −738 and/or two GATA binding sites at −748 and −697 (Fig. 3 c)	complete
	GO:0006366	transcription from RNA polymerase II promoter		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:19674970^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0000790	nuclear chromatin	PMID:20855495^[1]	IDA: Inferred from Direct Assay		C
	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:19723756^[3]	IDA: Inferred from Direct Assay		F
	GO:0000987	core promoter proximal region sequence-specific DNA binding	PMID:19232384^[4]	IDA: Inferred from Direct Assay		F
	GO:0001046	core promoter sequence-specific DNA binding	PMID:19674970^[2]	IDA: Inferred from Direct Assay		F
	GO:0001071	nucleic acid binding transcription factor activity	PMID:19232384^[4]	IDA: Inferred from Direct Assay		F
	GO:0001071	nucleic acid binding transcription factor activity	PMID:19674970^[2]	IMP: Inferred from Mutant Phenotype		F
	GO:0001071	nucleic acid binding transcription factor activity	PMID:19805038^[5]	IDA: Inferred from Direct Assay		F
	GO:0001071	nucleic acid binding transcription factor activity	PMID:20189993^[6]	IDA: Inferred from Direct Assay		F
	GO:0001071	nucleic acid binding transcription factor activity	PMID:20368097^[7]	IMP: Inferred from Mutant Phenotype		F
	GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	PMID:19674970^[2]	IMP: Inferred from Mutant Phenotype		F
	GO:0001709	cell fate determination	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0001822	kidney development	PMID:19248180^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0001822	kidney development	PMID:19723756^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0001823	mesonephros development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0003180	aortic valve morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0003215	cardiac right ventricle morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0003281	ventricular septum development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	PMID:1871134^[9]	TAS: Traceable Author Statement		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000679	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013088	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:2050118^[10]	TAS: Traceable Author Statement		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:8088776^[11]	TAS: Traceable Author Statement		F
	GO:0003713	transcription coactivator activity	PMID:20484083^[12]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:19674970^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P32519	F
	GO:0005515	protein binding	PMID:19674970^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q15723	F
	GO:0005515	protein binding	PMID:19723756^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q8WW38	F
	GO:0005515	protein binding	PMID:20484083^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O00255	F
	GO:0005515	protein binding	PMID:20484083^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P10242	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:11256614^[13]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18029348^[14]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:19674970^[2]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:19723756^[3]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:20189993^[6]	IDA: Inferred from Direct Assay		C
	GO:0005654	nucleoplasm	Reactome:REACT_25215	TAS: Traceable Author Statement		C
	GO:0005730	nucleolus	PMID:18029348^[14]	IDA: Inferred from Direct Assay		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000679	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013088	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:2050118^[10]	TAS: Traceable Author Statement		P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:8088776^[11]	TAS: Traceable Author Statement		P
	GO:0006366	transcription from RNA polymerase II promoter	PMID:1871134^[9]	TAS: Traceable Author Statement		P
	GO:0006952	defense response	PMID:7592673^[15]	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0008134	transcription factor binding	PMID:15016828^[16]	IPI: Inferred from Physical Interaction	UniProtKB:Q03014	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000679	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013088	F
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0008584	male gonad development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0009615	response to virus	PMID:20583921^[17]	IEP: Inferred from Expression Pattern		P
	GO:0009653	anatomical structure morphogenesis	PMID:10935639^[18]	TAS: Traceable Author Statement		P
	GO:0009967	positive regulation of signal transduction	PMID:19674970^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0010595	positive regulation of endothelial cell migration	PMID:19674970^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0014065	phosphatidylinositol 3-kinase cascade	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0031929	TOR signaling cascade	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	PMID:19483726^[19]	IDA: Inferred from Direct Assay		P
	GO:0035457	cellular response to interferon-alpha	PMID:20554961^[20]	IEP: Inferred from Expression Pattern		P
	GO:0042035	regulation of cytokine biosynthetic process	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0042421	norepinephrine biosynthetic process	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000679	F
	GO:0043583	ear development	PMID:19248180^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0043583	ear development	PMID:19723756^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0043627	response to estrogen stimulus	PMID:10037815^[21]	IEP: Inferred from Expression Pattern		P
	GO:0044212	transcription regulatory region DNA binding	PMID:19735555^[22]	IDA: Inferred from Direct Assay		F
	GO:0044212	transcription regulatory region DNA binding	PMID:19805038^[5]	IDA: Inferred from Direct Assay		F
	GO:0044212	transcription regulatory region DNA binding	PMID:20189993^[6]	IDA: Inferred from Direct Assay		F
	GO:0044212	transcription regulatory region DNA binding	PMID:20484083^[12]	IDA: Inferred from Direct Assay		F
	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0045599	negative regulation of fat cell differentiation	PMID:20705609^[23]	IMP: Inferred from Mutant Phenotype		P
	GO:0045786	negative regulation of cell cycle	PMID:20189993^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:19674970^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:19674970^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:19723756^[3]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:19805038^[5]	IDA: Inferred from Direct Assay		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:20368097^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:19232384^[4]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:20189993^[6]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:20484083^[12]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:20855495^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048485	sympathetic nervous system development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0050728	negative regulation of inflammatory response	PMID:19674970^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0050852	T cell receptor signaling pathway	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0051897	positive regulation of protein kinase B signaling cascade	PMID:19674970^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0060037	pharyngeal system development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0060065	uterus development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0060231	mesenchymal to epithelial transition	PMID:20189993^[6]	IDA: Inferred from Direct Assay		P
	GO:0060676	ureteric bud formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0061290	canonical Wnt receptor signaling pathway involved in metanephric kidney development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0070888	E-box binding	PMID:20855495^[1]	IDA: Inferred from Direct Assay		F
	GO:0071353	cellular response to interleukin-4	PMID:20554961^[20]	IEP: Inferred from Expression Pattern		P
	GO:0071356	cellular response to tumor necrosis factor	PMID:19674970^[2]	IEP: Inferred from Expression Pattern		P
	GO:0071837	HMG box domain binding	PMID:18445004^[24]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UJU2	F
	GO:0072107	positive regulation of ureteric bud formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0072178	nephric duct morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0072179	nephric duct formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0072182	regulation of nephron tubule epithelial cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:0072676	lymphocyte migration	PMID:19805038^[5]	IDA: Inferred from Direct Assay		P
	GO:2000146	negative regulation of cell motility	PMID:20189993^[6]	IMP: Inferred from Mutant Phenotype		P
	GO:2000352	negative regulation of endothelial cell apoptosis	PMID:19674970^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:2000607	negative regulation of cell proliferation involved in mesonephros development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:2000611	positive regulation of thyroid hormone generation	PMID:19248180^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:2000611	positive regulation of thyroid hormone generation	PMID:19723756^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:2000664	positive regulation of interleukin-5 secretion	PMID:20554961^[20]	IDA: Inferred from Direct Assay		P
	GO:2000667	positive regulation of interleukin-13 secretion	PMID:20368097^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:2000667	positive regulation of interleukin-13 secretion	PMID:20554961^[20]	IDA: Inferred from Direct Assay		P
	GO:2000679	positive regulation of transcription regulatory region DNA binding	PMID:20368097^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:2000683	regulation of cellular response to X-ray	PMID:19735555^[22]	IMP: Inferred from Mutant Phenotype		P
	GO:2000703	negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
	GO:2000734	negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P23772	P
NOT	GO:0005730	nucleolus	PMID:18029348^[14]	IDA: Inferred from Direct Assay		C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Kusy S et al. (2010) NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med 207: 2141-56 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 Song H et al. (2009) Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J Biol Chem 284: 29109-24 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaynor KU et al. (2009) A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome. J Clin Endocrinol Metab 94: 3897-904 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Son do N et al. (2009) Abundant expression of Kallikrein 1 gene in human keratinocytes was mediated by GATA3. Gene 436: 121-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Jenner RG et al. (2009) The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A 106: 17876-81 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Yan W et al. (2010) GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition. J Biol Chem 285: 14042-51 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Yao X et al. (2010) GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells. Chin Med J (Engl) 123: 739-44 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Ferraris S et al. (2009) HDR syndrome: a novel "de novo" mutation in GATA3 gene. Am J Med Genet A 149A: 770-5 PubMed GONUTS page
↑ ^9.0 ^9.1 Marine J & Winoto A (1991) The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. Proc Natl Acad Sci U S A 88: 7284-8 PubMed GONUTS page
↑ ^10.0 ^10.1 Joulin V et al. (1991) A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J 10: 1809-16 PubMed GONUTS page
↑ ^11.0 ^11.1 Labastie MC et al. (1994) Structure and expression of the human GATA3 gene. Genomics 21: 1-6 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Nakata Y et al. (2010) c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood 116: 1280-90 PubMed GONUTS page
↑ Simpson JC et al. (2000) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep 1: 287-92 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ Siegel MD et al. (1995) Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements. J Biol Chem 270: 24548-55 PubMed GONUTS page
↑ Minami T et al. (2004) Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling. J Biol Chem 279: 20626-35 PubMed GONUTS page
↑ Díaz YR et al. (2010) T-bet, GATA-3, and Foxp3 expression and Th1/Th2 cytokine production in the clinical outcome of human infection with Leishmania (Viannia) species. J Infect Dis 202: 406-15 PubMed GONUTS page
↑ Van Esch H et al. (2000) GATA3 haplo-insufficiency causes human HDR syndrome. Nature 406: 419-22 PubMed GONUTS page
↑ Dydensborg AB et al. (2009) GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis. Oncogene 28: 2634-42 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Huber JP et al. (2010) Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. J Immunol 185: 813-7 PubMed GONUTS page
↑ Yang GP et al. (1999) Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes. Nucleic Acids Res 27: 1517-23 PubMed GONUTS page
↑ ^22.0 ^22.1 Bonin F et al. (2009) GATA3 is a master regulator of the transcriptional response to low-dose ionizing radiation in human keratinocytes. BMC Genomics 10: 417 PubMed GONUTS page
↑ Jack BH & Crossley M (2010) GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis. J Biol Chem 285: 32405-14 PubMed GONUTS page
↑ Hossain MB et al. (2008) Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells. Immunology 125: 377-86 PubMed GONUTS page

[PMID:20855495-0] 1.0 ^1.1 ^1.2 ^1.3 Kusy S et al. (2010) NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med 207: 2141-56 PubMed GONUTS page

[PMID:19674970-1] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 Song H et al. (2009) Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J Biol Chem 284: 29109-24 PubMed GONUTS page

[PMID:19723756-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaynor KU et al. (2009) A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome. J Clin Endocrinol Metab 94: 3897-904 PubMed GONUTS page

[PMID:19232384-3] 4.0 ^4.1 ^4.2 Son do N et al. (2009) Abundant expression of Kallikrein 1 gene in human keratinocytes was mediated by GATA3. Gene 436: 121-7 PubMed GONUTS page

[PMID:19805038-4] 5.0 ^5.1 ^5.2 ^5.3 Jenner RG et al. (2009) The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A 106: 17876-81 PubMed GONUTS page

[PMID:20189993-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Yan W et al. (2010) GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition. J Biol Chem 285: 14042-51 PubMed GONUTS page

[PMID:20368097-6] 7.0 ^7.1 ^7.2 ^7.3 Yao X et al. (2010) GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells. Chin Med J (Engl) 123: 739-44 PubMed GONUTS page

[PMID:19248180-7] 8.0 ^8.1 ^8.2 Ferraris S et al. (2009) HDR syndrome: a novel "de novo" mutation in GATA3 gene. Am J Med Genet A 149A: 770-5 PubMed GONUTS page

[PMID:1871134-8] 9.0 ^9.1 Marine J & Winoto A (1991) The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. Proc Natl Acad Sci U S A 88: 7284-8 PubMed GONUTS page

[PMID:2050118-9] 10.0 ^10.1 Joulin V et al. (1991) A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J 10: 1809-16 PubMed GONUTS page

[PMID:8088776-10] 11.0 ^11.1 Labastie MC et al. (1994) Structure and expression of the human GATA3 gene. Genomics 21: 1-6 PubMed GONUTS page

[PMID:20484083-11] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Nakata Y et al. (2010) c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood 116: 1280-90 PubMed GONUTS page

[PMID:11256614-12] Simpson JC et al. (2000) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep 1: 287-92 PubMed GONUTS page

[PMID:18029348-13] 14.0 ^14.1 ^14.2 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

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