Ambox notice.png

GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.

You can help reduce stress on the server by:

  1. not reloading pages frequently - this just adds
  2. opening links in new windows (so you can read the old page)

HUMAN:GAB1

From GONUTS
Jump to: navigation, search

Contents

Species (Taxon ID) Homo sapiens (Human). (taxon:9606)
Gene Name(s) GAB1
Protein Name(s)
  • GRB2-associated-binding protein 1
  • GRB2-associated binder 1
  • Growth factor receptor bound protein 2-associated protein 1
External Links
UniProt Identifier GAB1_HUMAN
UniProt Accessions Q13480, A8K152, Q4W5G2, Q6P1W2,
EMBL U43885, DQ021880, AK289767, AC097658, AC104685, CH471056, BC064848,
PIR S68442,
RefSeq NP_002030.2, NP_997006.1,
IntAct Q13480,
Ensembl ENST00000262994,
Pfam PF00169,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005829

cytosol

PMID:15574420[1]

EXP: Inferred from Experiment

C

GO:0005829

cytosol

PMID:10648629[2]

EXP: Inferred from Experiment

C

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q05209

F

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:P23467

F

GO:0005829

cytosol

Reactome:REACT_12535

TAS: Traceable Author Statement

C

GO:0007173

epidermal growth factor receptor signaling pathway

PMID:8596638[4]

TAS: Traceable Author Statement

P

GO:0008283

cell proliferation

PMID:8596638[4]

TAS: Traceable Author Statement

P

GO:0005829

cytosol

PMID:9045692[5]

EXP: Inferred from Experiment

C

GO:0005829

cytosol

Reactome:REACT_12490

TAS: Traceable Author Statement

C

GO:0008286

insulin receptor signaling pathway

PMID:8596638[4]

TAS: Traceable Author Statement

P

GO:0005829

cytosol

PMID:10734310[6]

EXP: Inferred from Experiment

C

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q16827

F

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q12913

F

GO:0005829

cytosol

PMID:14560030[7]

EXP: Inferred from Experiment

C

GO:0005515

protein binding

PMID:9658397[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q06124

F

GO:0008286

insulin receptor signaling pathway

Reactome:REACT_498

TAS: Traceable Author Statement

P

GO:0005829

cytosol

PMID:12660731[9]

EXP: Inferred from Experiment

C

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:P43378

F

GO:0005829

cytosol

Reactome:REACT_12466

TAS: Traceable Author Statement

C

GO:0005829

cytosol

PMID:11353842[10]

EXP: Inferred from Experiment

C

GO:0005829

cytosol

PMID:9356464[11]

EXP: Inferred from Experiment

C

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:P08575

F

GO:0005829

cytosol

PMID:14665621[12]

EXP: Inferred from Experiment

C

GO:0007173

epidermal growth factor receptor signaling pathway

Reactome:REACT_9417

TAS: Traceable Author Statement

P

GO:0005829

cytosol

PMID:10913131[13]

EXP: Inferred from Experiment

C

GO:0005829

cytosol

PMID:11606067[14]

EXP: Inferred from Experiment

C

GO:0005070

SH3/SH2 adaptor activity

PMID:8596638[4]

TAS: Traceable Author Statement

F

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_9470

TAS: Traceable Author Statement

P

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:P23470

F

GO:2000147

positive regulation of cell motility

PMID:20506405[15]

IDA: Inferred from Direct Assay

P

Figure 2. Gab1 constitutively enhances migration and stimulates adhesion of 32D/Met cells. A: The migration of 32D/Met cells (open bars), 32D/Met/Gab1clone 1W5 (black bars), and 32D/Met/Gab1 clone 1W3 (gray bars) was measured using modified Boyden chambers. NK1 concentrations are indicated on the X-axis. Results are expressed as number of migrating cells/ml of medium in the bottom chamber and are representative of three or more experiments.

complete

GO:0005070

SH3/SH2 adaptor activity

PMID:8596638[4]

TAS: Traceable Author Statement

F

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:P08575

F

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:P23467

F

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:P23470

F

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:P43378

F

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q05209

F

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q12913

F

GO:0005515

protein binding

PMID:19167335[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q16827

F

GO:0005515

protein binding

PMID:9658397[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q06124

F

GO:0005829

cytosol

Reactome:REACT_12390

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_12423

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_12425

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_12466

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_12490

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_12501

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_12534

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_12535

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_12601

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_12605

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_12616

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_12629

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_12636

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_21339

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_21411

TAS: Traceable Author Statement

C

GO:0005829

cytosol

Reactome:REACT_244

TAS: Traceable Author Statement

C

GO:0007173

epidermal growth factor receptor signaling pathway

PMID:8596638[4]

TAS: Traceable Author Statement

P

GO:0007173

epidermal growth factor receptor signaling pathway

Reactome:REACT_9417

TAS: Traceable Author Statement

P

GO:0008283

cell proliferation

PMID:8596638[4]

TAS: Traceable Author Statement

P

GO:0008286

insulin receptor signaling pathway

PMID:8596638[4]

TAS: Traceable Author Statement

P

GO:0008286

insulin receptor signaling pathway

Reactome:REACT_498

TAS: Traceable Author Statement

P

GO:0008543

fibroblast growth factor receptor signaling pathway

Reactome:REACT_9470

TAS: Traceable Author Statement

P


edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Montagner A et al. (2005) A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation. J Biol Chem 280: 5350-60 PubMed GONUTS page
  2. ↑ Rodrigues GA et al. (2000) A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol Cell Biol 20: 1448-59 PubMed GONUTS page
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 Barr AJ et al. (2009) Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell 136: 352-63 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Holgado-Madruga M et al. (1996) A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379: 560-4 PubMed GONUTS page
  5. ↑ Kanai M et al. (1997) Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. J Biol Chem 272: 6621-8 PubMed GONUTS page
  6. ↑ Gual P et al. (2000) Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis. Oncogene 19: 1509-18 PubMed GONUTS page
  7. ↑ Agazie YM & Hayman MJ (2003) Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling. Mol Cell Biol 23: 7875-86 PubMed GONUTS page
  8. ↑ 8.0 8.1 Rocchi S et al. (1998) Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules. Mol Endocrinol 12: 914-23 PubMed GONUTS page
  9. ↑ Koyasu S (2003) The role of PI3K in immune cells. Nat Immunol 4: 313-9 PubMed GONUTS page
  10. ↑ Ong SH et al. (2001) Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc Natl Acad Sci U S A 98: 6074-9 PubMed GONUTS page
  11. ↑ Holgado-Madruga M et al. (1997) Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. Proc Natl Acad Sci U S A 94: 12419-24 PubMed GONUTS page
  12. ↑ Ren Y et al. (2004) Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor. J Biol Chem 279: 8497-505 PubMed GONUTS page
  13. ↑ Lock LS et al. (2000) Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases. J Biol Chem 275: 31536-45 PubMed GONUTS page
  14. ↑ Onishi-Haraikawa Y et al. (2001) Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein. Biochem Biophys Res Commun 288: 476-82 PubMed GONUTS page
  15. ↑ Felici A et al. (2010) Gab1 mediates hepatocyte growth factor-stimulated mitogenicity and morphogenesis in multipotent myeloid cells. J Cell Biochem 111: 310-21 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/HUMAN:GAB1"
Personal tools
Namespaces
Variants
Actions
Navigation
Cacao
Journal Clubs
page contributors
Toolbox