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HUMAN:FUS
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | FUS (synonyms: TLS) | |
| Protein Name(s) | RNA-binding protein FUS
75 kDa DNA-pairing protein Oncogene FUS Oncogene TLS POMp75 Translocated in liposarcoma protein | |
| External Links | ||
| EMBL | S62140 S62138 X71427 X71428 AF071213 AF071213 AC009088 BC000402 BC002459 AJ295163 | |
| IPI | IPI00221354 IPI00260715 | |
| PIR | S33798 S33799 | |
| RefSeq | NP_001164105.1 NP_004951.1 | |
| UniGene | Hs.46894 | |
| PDB | 2LA6 | |
| PDBsum | 2LA6 | |
| ProteinModelPortal | P35637 | |
| SMR | P35637 | |
| DIP | DIP-29857N | |
| IntAct | P35637 | |
| MINT | MINT-5005976 | |
| STRING | P35637 | |
| PhosphoSite | P35637 | |
| PRIDE | P35637 | |
| Ensembl | ENST00000254108 | |
| GeneID | 2521 | |
| KEGG | hsa:2521 | |
| UCSC | uc002ebf.1 uc002ebh.1 | |
| CTD | 2521 | |
| GeneCards | GC16P028753 | |
| H-InvDB | HIX0012983 | |
| HGNC | HGNC:4010 | |
| HPA | HPA008784 | |
| MIM | 137070 608030 612160 | |
| neXtProt | NX_P35637 | |
| Orphanet | 803 282 79105 99967 | |
| PharmGKB | PA28425 | |
| eggNOG | prNOG17659 | |
| HOVERGEN | HBG095056 | |
| InParanoid | P35637 | |
| OMA | QYNSSGG | |
| OrthoDB | EOG4DV5NH | |
| PhylomeDB | P35637 | |
| Reactome | REACT_1675 REACT_71 | |
| NextBio | 9927 | |
| ArrayExpress | P35637 | |
| Bgee | P35637 | |
| CleanEx | HS_FUS | |
| Genevestigator | P35637 | |
| GermOnline | ENSG00000089280 | |
| GO | GO:0005654 GO:0003677 GO:0000166 GO:0005515 GO:0003723 GO:0008270 GO:0008219 GO:0000398 | |
| InterPro | IPR012677 IPR000504 IPR001876 | |
| Gene3D | G3DSA:3.30.70.330 | |
| Pfam | PF00076 PF00641 | |
| SMART | SM00360 SM00547 | |
| PROSITE | PS50102 PS01358 PS50199 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0000398 |
nuclear mRNA splicing, via spliceosome |
Reactome:REACT_467 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0003676 |
nucleic acid binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003723 |
RNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003723 |
RNA binding |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005622 |
intracellular |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000101858 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_1331 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_1554 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_1935 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_222 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_48 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_625 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_774 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_788 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000101858 |
C |
Seeded From UniProt |
|||
| GO:0008219 |
cell death |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008270 |
zinc ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008380 |
RNA splicing |
Reactome:REACT_1735 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0010467 |
gene expression |
Reactome:REACT_71 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005730 |
nucleolus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
C |
Figure 2. Subcellular localization of FUS in prostate cancer cells |
complete | |||
| GO:0003713 |
transcription coactivator activity |
IDA: Inferred from Direct Assay |
F |
Figure 1 establishes that FUS is complexed with AR. Figure 3 demonstrates that FUS possesses innate ability to regulate transcription. Figure 4 demonstrates that FUS modulates AR activity. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Crozat A et al. (1993) Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 363: 640-4 PubMed GONUTS page
- ↑ Edelmann MJ et al. (2009) Structural basis and specificity of human otubain 1-mediated deubiquitination. Biochem J 418: 379-90 PubMed GONUTS page
- ↑ Amoresano A et al. (2010) Identification of DeltaNp63alpha protein interactions by mass spectrometry. J Proteome Res 9: 2042-8 PubMed GONUTS page
- ↑ Yang L et al. (1998) Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J Biol Chem 273: 27761-4 PubMed GONUTS page
- ↑ Radic MZ et al. (2006) Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody target in mice deficient for Mer, Axl, and Tyro3 receptor tyrosine kinases. J Immunol 176: 68-74 PubMed GONUTS page
- ↑ 6.0 6.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
- ↑ 7.0 7.1 Haile S et al. (2011) FUS/TLS is a co-activator of androgen receptor in prostate cancer cells. PLoS One 6: e24197 PubMed GONUTS page
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