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HUMAN:FRIL
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | FTL | |
| Protein Name(s) | Ferritin light chain
Ferritin L subunit | |
| External Links | ||
| EMBL | M11147 M10119 M12938 AY207005 CR456715 AK311773 BX571748 AC026803 BC002991 BC004245 BC008439 BC013928 BC016715 BC016346 BC016354 BC018990 BC021670 BC058820 BC062708 X03742 X03743 X03743 | |
| IPI | IPI01014563 | |
| PIR | B23920 | |
| RefSeq | NP_000137.2 | |
| UniGene | Hs.433670 Hs.728304 | |
| PDB | 2FFX 2FG4 2FG8 3HX2 3HX5 3HX7 3KXU | |
| PDBsum | 2FFX 2FG4 2FG8 3HX2 3HX5 3HX7 3KXU | |
| ProteinModelPortal | P02792 | |
| SMR | P02792 | |
| IntAct | P02792 | |
| MINT | MINT-1187221 | |
| STRING | P02792 | |
| PhosphoSite | P02792 | |
| Cornea-2DPAGE | P02792 | |
| PRIDE | P02792 | |
| Ensembl | ENST00000331825 | |
| GeneID | 2512 | |
| KEGG | hsa:2512 | |
| UCSC | uc002plo.1 | |
| CTD | 2512 | |
| GeneCards | GC19P045848 | |
| H-InvDB | HIX0015310 | |
| HGNC | HGNC:3999 | |
| HPA | CAB020769 | |
| MIM | 134790 600886 606159 | |
| neXtProt | NX_P02792 | |
| Orphanet | 254704 163 157846 | |
| PharmGKB | PA28412 | |
| HOVERGEN | HBG000410 | |
| InParanoid | P02792 | |
| OMA | QDLQKPS | |
| OrthoDB | EOG47PX78 | |
| Reactome | REACT_11123 | |
| DrugBank | DB00893 | |
| NextBio | 9899 | |
| ArrayExpress | P02792 | |
| Bgee | P02792 | |
| CleanEx | HS_FTL | |
| Genevestigator | P02792 | |
| GermOnline | ENSG00000087086 | |
| GO | GO:0005829 GO:0008043 GO:0008199 GO:0042802 GO:0016491 GO:0008219 GO:0006879 GO:0016044 GO:0006826 GO:0006892 | |
| InterPro | IPR001519 IPR009040 IPR012347 IPR009078 IPR014034 IPR008331 | |
| Gene3D | G3DSA:1.20.1260.10 | |
| KO | K13625 | |
| PANTHER | PTHR11431 | |
| Pfam | PF00210 | |
| SUPFAM | SSF47240 | |
| PROSITE | PS00540 PS00204 PS50905 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005488 |
binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005506 |
iron ion binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005506 |
iron ion binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005506 |
iron ion binding |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
Reactome:REACT_19237 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0006826 |
iron ion transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006879 |
cellular iron ion homeostasis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006879 |
cellular iron ion homeostasis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006879 |
cellular iron ion homeostasis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006879 |
cellular iron ion homeostasis |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006892 |
post-Golgi vesicle-mediated transport |
Reactome:REACT_11235 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0008043 |
intracellular ferritin complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0008043 |
intracellular ferritin complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0008043 |
intracellular ferritin complex |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0008199 |
ferric iron binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008199 |
ferric iron binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008219 |
cell death |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016044 |
cellular membrane organization |
Reactome:REACT_11123 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0016491 |
oxidoreductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0042802 |
identical protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0046914 |
transition metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0055072 |
iron ion homeostasis |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0055114 |
oxidation-reduction process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
| |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Baraibar MA et al. (2010) Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration. J Biol Chem 285: 1950-6 PubMed GONUTS page
- ↑ 2.0 2.1 Luscieti S et al. (2010) Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation. J Biol Chem 285: 11948-57 PubMed GONUTS page
- ↑ Beaumont C et al. (1995) Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract. Nat Genet 11: 444-6 PubMed GONUTS page
- ↑ 4.0 4.1 Girelli D et al. (1995) Molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome: a mutation in the iron-responsive element of ferritin L-subunit gene (the "Verona mutation") Blood 86: 4050-3 PubMed GONUTS page
- ↑ Rual JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437: 1173-8 PubMed GONUTS page
